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Chemical Structure| 83207-58-3 Chemical Structure| 83207-58-3

Structure of Astragaloside A
CAS No.: 83207-58-3

Chemical Structure| 83207-58-3

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Astragaloside A is one of the major active constituents of Astragalus membranaceus in traditional Chinese medicine and has been widely used to treat ischemic diseases.

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Product Details of Astragaloside A

CAS No. :83207-58-3
Formula : C41H68O14
M.W : 784.97
SMILES Code : O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O[C@H]2C[C@]([C@@](C[C@H](O)[C@]3([H])[C@@]4(CC[C@H](C(C)(C)O)O4)C)(C)[C@]3(C)CC5)([H])[C@@]65[C@]7(C6)[C@]2([H])C(C)(C)[C@@H](O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O)CC7)[C@@H]1O
InChI Key :QMNWISYXSJWHRY-AUJDEUPOSA-N
Pubchem ID :13943299

Safety of Astragaloside A

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c and C57/BL6J mice Bright light exposure and DNA alkylating agent methyl methanesulfonate (MMS)-induced photoreceptor degeneration model Intraperitoneal injection 6.25 mg/kg, 25 mg/kg, 100 mg/kg Single administration (30 min prior to bright light exposure) or twice daily administration (MMS-induced model) To evaluate the protective effects of Astragaloside A against photooxidative stress and DNA damage-mediated photoreceptor degeneration. Results showed that Astragaloside A protected photoreceptors from degeneration by mitigating oxidative stress and DNA damage-induced necroptosis and inflammatory responses. PMC9130102

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.37mL

1.27mL

0.64mL

12.74mL

2.55mL

1.27mL

References

 

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