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Chemical Structure| 1117684-36-2 Chemical Structure| 1117684-36-2

Structure of AZ12799734
CAS No.: 1117684-36-2

Chemical Structure| 1117684-36-2

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AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC50 of 47 nM. This compound simultaneously inhibits BMP and TGFβ signaling pathways, making it suitable for studies related to fibrosis and tumor-related research.

Synonyms: AZ12799734

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Product Details of AZ12799734

CAS No. :1117684-36-2
Formula : C18H18N4O3S
M.W : 370.43
SMILES Code : O=S(C1=CC=C(NC2=NC=CC(OC3=CC=C(C)N=C3C)=C2)C=C1)(N)=O
Synonyms :
AZ12799734
MDL No. :MFCD26397939

Safety of AZ12799734

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
AZ12799734, a selective and orally active TGFBR1 kinase inhibitor, boasts an IC50 of 47 nM and also inhibits both BMP and TGFβ broadly[1].

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1 mM

5 mM

10 mM

2.70mL

0.54mL

0.27mL

13.50mL

2.70mL

1.35mL

27.00mL

5.40mL

2.70mL

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