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Chemical Structure| 1204144-28-4 Chemical Structure| 1204144-28-4

Structure of AZD-1208
CAS No.: 1204144-28-4

Chemical Structure| 1204144-28-4

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AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases (IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively) and is used for treating AML.

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Product Details of AZD-1208

CAS No. :1204144-28-4
Formula : C21H21N3O2S
M.W : 379.48
SMILES Code : O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2
InChI Key :MCUJKPPARUPFJM-UWCCDQBKSA-N
Pubchem ID :58423153

Safety of AZD-1208

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of AZD-1208

epigenetics
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • Pim3

    Pim3, IC50:1.9 nM

  • Pim1

    Pim1, IC50:0.4 nM

  • Pim2

    Pim2, IC50:5 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
32D/TKD cells 1 μM 48 hours AZD1208 overcame the resistance of STAT5A1*6-expressing cells Transl Oncol. 2019 Feb;12(2):336-349.

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.18mL

2.64mL

1.32mL

26.35mL

5.27mL

2.64mL

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