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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 869357-68-6 Chemical Structure| 869357-68-6

Structure of AZD8330
CAS No.: 869357-68-6

Chemical Structure| 869357-68-6

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AZD8330 is a selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.

Synonyms: ARRY-424704; ARRY-704

4.5 *For Research Use Only !

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Product Details of AZD8330

CAS No. :869357-68-6
Formula : C16H17FIN3O4
M.W : 461.23
SMILES Code : O=C(C(C=C1C)=C(NC2=CC=C(I)C=C2F)N(C)C1=O)NOCCO
Synonyms :
ARRY-424704; ARRY-704
MDL No. :MFCD18384989
InChI Key :RWEVIPRMPFNTLO-UHFFFAOYSA-N
Pubchem ID :16666708

Safety of AZD8330

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H372
Precautionary Statements:P260-P264-P270-P301+P310-P314-P321-P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of AZD8330

MAPK

Isoform Comparison

Biological Activity

Target
  • MEK1/2

    MEK1/2, IC50:7 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
Raji cells 50nM 24 h To validate the inhibitory effect of AZD8330 on the Ras/MEK/ERK pathway, results showed that AZD8330 significantly inhibited the phosphorylation levels of MEK and ERK Onco Targets Ther. 2020 Jun 18;13:5795-5805

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Caenorhabditis elegans ST65 (ncIs13) strain Liquid culture 50 μM 5 days AZD8330 significantly inhibited vulva formation in C. elegans at 50 μmol/L, with only 3.8% of individuals forming a vulva. This experiment validated the inhibitory effect of AZD8330 as a MEK inhibitor on the MAPK/ERK signaling pathway in vivo. Cancer Res Commun. 2024 Sep 1;4(9):2454-2462

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.84mL

2.17mL

1.08mL

21.68mL

4.34mL

2.17mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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