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CAS No. :	722543-31-9
Formula :	C₂₆H₃₁FN₇O₆P
M.W :	587.54
SMILES Code :	O=P(OCCN(CCCOC1=CC2=NC=NC(NC3=NNC(CC(NC4=CC=CC(F)=C4)=O)=C3)=C2C=C1)CC)(O)O
Synonyms :	Azd1152
MDL No. :	MFCD15146330

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

PC9-ER	0.06 µM	72 h	Barasertib showed strong antiproliferative effects with IC50 < 0.06 µM	Nat Commun. 2019 Apr 18;10(1):1812
PC9-GR3	0.05 µM	72 h	Barasertib showed strong antiproliferative effects with IC50 < 0.06 µM	Nat Commun. 2019 Apr 18;10(1):1812
PC9-GR1-AZD4	0.03 µM	72 h	Barasertib showed strong antiproliferative effects with IC50 < 0.06 µM	Nat Commun. 2019 Apr 18;10(1):1812
PC9-GR1-AZD3	0.03 µM	72 h	Barasertib showed strong antiproliferative effects with IC50 < 0.06 µM	Nat Commun. 2019 Apr 18;10(1):1812
PC9-GR1-AZD2	0.03 µM	72 h	Barasertib showed strong antiproliferative effects with IC50 < 0.06 µM	Nat Commun. 2019 Apr 18;10(1):1812
PC9-GR1-AZD1	0.04 µM	72 h	Barasertib showed strong antiproliferative effects with IC50 < 0.06 µM	Nat Commun. 2019 Apr 18;10(1):1812
BT-474	8 nM		AZD1152-HQPA inhibited cell proliferation	Mol Cancer. 2010 Feb 22;9:42
MDA-MB-361	70 nM		AZD1152-HQPA inhibited cell proliferation	Mol Cancer. 2010 Feb 22;9:42
MDA-MB-231	105 nM		AZD1152-HQPA inhibited cell proliferation and induced apoptosis	Mol Cancer. 2010 Feb 22;9:42
MDA-MB-435	125 nM		AZD1152-HQPA inhibited cell proliferation	Mol Cancer. 2010 Feb 22;9:42
MDA-MB-468	14 nM		AZD1152-HQPA inhibited cell proliferation	Mol Cancer. 2010 Feb 22;9:42
HER18	20 nM	48 h	AZD1152-HQPA inhibited Aurora B kinase activity, leading to mitotic catastrophe, polyploidy, and apoptosis	Mol Cancer. 2010 Feb 22;9:42
11-18-GR5	0.06 µM	72 h	Barasertib showed strong antiproliferative effects with IC50s in the nM range	Nat Commun. 2019 Apr 18;10(1):1812
11-18-GR3	0.06 µM	72 h	Barasertib showed strong antiproliferative effects with IC50s in the nM range	Nat Commun. 2019 Apr 18;10(1):1812
PC9-GR5	0.04 µM	72 h	Barasertib showed strong antiproliferative effects with IC50 < 0.06 µM	Nat Commun. 2019 Apr 18;10(1):1812
Cord blood Lin− cells	10 nM, 100 nM, 1000 nM	2 weeks	AZD1152-HQPA showed a dose-dependent effect on the growth and differentiation of cord blood progenitor cells, with no colonies detected at 1000 nM.	Cancer Res. 2009 May 15;69(10):4150-8
THP-1 cells	100 nM	96 h	THP-1 cells showed a low apoptotic response to AZD1152-HQPA, with more than 80% of cells remaining polyploid at 100 nM and exhibiting senescence-associated β-galactosidase activity.	Cancer Res. 2009 May 15;69(10):4150-8
HL-60 cells	0–1000 nM	96 h	AZD1152-HQPA exerted anti-proliferative or cytotoxic effects in all cell lines studied, inhibited the phosphorylation of histone H3 (pHis H3) on ser10 in a dose dependent manner and resulted in cells with more than 4N DNA content.	Cancer Res. 2009 May 15;69(10):4150-8
PAH-PASMCs	0.5 μM	48 h	To evaluate the effect of Barasertib on proliferation and apoptosis of PAH-PASMCs. Results showed that Barasertib dose-dependently reduced proliferation of PAH-PASMCs (assessed by EdU incorporation and Ki67 labeling) and significantly decreased the resistance of PAH-PASMCs to apoptosis under serum starvation (assessed by Annexin V and TUNEL labeling).	Cell Rep Med. 2025 Feb 18;6(2):101964
mouse lung fibroblasts	5 μM	48 h	To assess the effect of Barasertib on fibroblast proliferation, results showed Barasertib significantly reduced BrdU incorporation	EMBO Mol Med. 2020 Sep 7;12(9):e12131
human IPF lung fibroblasts	5 μM	48 h	To assess the effect of Barasertib on fibroblast proliferation, results showed Barasertib significantly reduced BrdU incorporation	EMBO Mol Med. 2020 Sep 7;12(9):e12131

NSG mice	Patient-derived xenograft model	Oral gavage and intraperitoneal injection	25 mg/kg	Once daily, 3 days on and 4 days off	Evaluate the inhibitory effect of TAZ and barasertib combination on tumor growth	Cancer Discov. 2024 Jun 3;14(6):965-981.
Rats	MCT-induced PAH model	Intraperitoneal injection	30 mg/kg	Three times a week from day 14 to 28	To evaluate the therapeutic effect of Barasertib in MCT-induced PAH rats. Results showed that Barasertib significantly reduced right ventricular hypertrophy (assessed by Fulton index) and right ventricular systolic pressure (RVSP) and mean pulmonary artery pressure (mPAP) (assessed by right heart catheterization). Additionally, Barasertib significantly attenuated vascular remodeling in distal pulmonary arteries (assessed by Elastica van Gieson staining).	Cell Rep Med. 2025 Feb 18;6(2):101964
NOD/SCID mice	HL-60 cell xenograft model	Subcutaneous osmotic pump	25 mg/kg/day	1 week continuously	AZD1152 at 25 mg/kg/day significantly reduced the growth of HL-60 cell xenografts, with no regrowth observed post-treatment.	Cancer Res. 2009 May 15;69(10):4150-8
Nude mice	Breast cancer xenograft model	Intraperitoneal injection	62.5 mg/kg and 125 mg/kg	Every 7 days for a cycle, administered on days 1 and 2, total of 3 cycles	AZD1152 suppressed tumor growth, reduced Ki-67 expression, and increased Caspase 3 cleavage	Mol Cancer. 2010 Feb 22;9:42
Nude mice	CaLu-6 NSCLC human tumour xenograft model	Subcutaneous osmotic mini-pump	150 mg/kg	2 consecutive days, once daily, followed by a 24-hour gap	To investigate the anti-tumour efficacy of Barasertib in combination with the MEK inhibitor selumetinib. Results showed enhanced tumour growth inhibition and increased cell death when Barasertib was administered before selumetinib.	Br J Cancer. 2012 Feb 28;106(5):858-66
Mice	TGFα-induced pulmonary fibrosis model	Intraperitoneal injection	40 mg/kg body weight	Twice a day for 4 weeks	To evaluate the preventive effect of Barasertib on pulmonary fibrosis, results showed Barasertib significantly reduced collagen deposition and lung weight	EMBO Mol Med. 2020 Sep 7;12(9):e12131
Nude mice	AA TNBC xenograft model	Intraperitoneal injection	100 mg/kg	Twice weekly for up to 28 days	To evaluate the effect of Barasertib on the growth of AA TNBC xenografts, results showed that Barasertib significantly inhibited the growth of AA TNBC xenografts.	Cell Death Dis. 2023 Jan 10;14(1):12

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CAS No.: 722543-31-9

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CAS No.: 722543-31-9

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed