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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Bemegride can stimulate central nervous system and release barbiturate poisoning.
Synonyms: Bemegrid; 3-Ethyl-3-methylglutarimide; Zentraleptin
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 64-65-3 |
Formula : | C8H13NO2 |
M.W : | 155.19 |
SMILES Code : | CCC1(C)CC(=O)NC(=O)C1 |
Synonyms : |
Bemegrid; 3-Ethyl-3-methylglutarimide; Zentraleptin
|
MDL No. : | MFCD00006673 |
InChI Key : | ORRZGUBHBVWWOP-UHFFFAOYSA-N |
Pubchem ID : | 2310 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonia; In water; at 180℃; for 1.0h; | General procedure: a) for compounds of formula (V) with G moiety, wherein L represents C=0, E, if present, is different from O, NH or N-(d-C3)alkyl (imide derivatives) To the appropriate dicarboxylic acid (Via) or acid anhydride (VIb) (0.05 mol) 25% aqueous ammonia (equivalent to 0.05 mol ammonia) and distilled water (10 ml) were added. The mixture was placed in a sand bath and heated until the water evaporates, and then it was heated for 1 hour at 180C. Crude products were purified by crystallization from methanol or 2-propanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20℃; | General procedure: To a suspension of corresponding cyclic imide 1a-1k (4mmol), potassium carbonate (4.4mmol) in DMF (5mL), 1-bromo-4-chlorobutane (1,2-dibromoethane (5 eq) for 2l, 1-bromo-3-chloropropane for 2m, 1-bromo-5-chloropentane for 2n) (4.4mmol) was added dropwise at 0C. The mixture was stirred at room temperature overnight and then partitioned between ethyl acetate (EA, 20mL) and water (30mL). The organic layer was washed successively with water (3×30mL), saturated brine, and dried over anhydrous Na2SO4. The solvent was evaporated under vacuum and the residue was purified by column chromatography using petroleum ether(PE): EA (8:1) as eluent to give 2a-2n. |