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Chemical Structure| 64-65-3 Chemical Structure| 64-65-3
Chemical Structure| 64-65-3

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Bemegride can stimulate central nervous system and release barbiturate poisoning.

Synonyms: Bemegrid; 3-Ethyl-3-methylglutarimide; Zentraleptin

4.5 *For Research Use Only !

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Product Details of Bemegride

CAS No. :64-65-3
Formula : C8H13NO2
M.W : 155.19
SMILES Code : CCC1(C)CC(=O)NC(=O)C1
Synonyms :
Bemegrid; 3-Ethyl-3-methylglutarimide; Zentraleptin
MDL No. :MFCD00006673
InChI Key :ORRZGUBHBVWWOP-UHFFFAOYSA-N
Pubchem ID :2310

Safety of Bemegride

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Bemegride

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64-65-3 ]

[ 64-65-3 ] Synthesis Path-Downstream   1~35

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YieldReaction ConditionsOperation in experiment
With ammonia; In water; at 180℃; for 1.0h; General procedure: a) for compounds of formula (V) with G moiety, wherein L represents C=0, E, if present, is different from O, NH or N-(d-C3)alkyl (imide derivatives) To the appropriate dicarboxylic acid (Via) or acid anhydride (VIb) (0.05 mol) 25% aqueous ammonia (equivalent to 0.05 mol ammonia) and distilled water (10 ml) were added. The mixture was placed in a sand bath and heated until the water evaporates, and then it was heated for 1 hour at 180C. Crude products were purified by crystallization from methanol or 2-propanol.
  • 22
  • 2.6-dioxo-4-methyl-4-ethyl-3-cyano-piperidine-carboxylic acid-(5)-amide [ No CAS ]
  • [ 64-65-3 ]
  • 23
  • 2-oxo-6-imino-4-methyl-4-ethyl-3-cyano-piperidine-carboxylic acid-(5)-amide [ No CAS ]
  • [ 64-65-3 ]
  • 24
  • <2,6-dioxo-4-methyl-4-ethyl-piperidine-dicarboxylic acid-(3,5)>-imide [ No CAS ]
  • [ 64-65-3 ]
  • 25
  • ammonium salt of/the/ β-methyl-β-ethyl-glutaric acid [ No CAS ]
  • [ 64-65-3 ]
  • 26
  • [ 872821-77-7 ]
  • diluted KOH-solution [ No CAS ]
  • [ 64-65-3 ]
  • 27
  • 4-ethyl-5-cyano-4-methyl-2,6-dioxo-piperidine-3-carboxylic acid amide [ No CAS ]
  • diluted KOH-solution [ No CAS ]
  • [ 64-65-3 ]
  • 28
  • [ 64-65-3 ]
  • [ 100-39-0 ]
  • [ 63515-89-9 ]
  • 29
  • [ 64-65-3 ]
  • 4,7-dimethyl-1-aza-norbornane [ No CAS ]
  • 30
  • [ 64-65-3 ]
  • 4-ethyl-4-methyl-1-(toluene-4-sulfonyl)-piperidine [ No CAS ]
  • 31
  • [ 64-65-3 ]
  • [ 15077-29-9 ]
  • 32
  • [ 7631-99-4 ]
  • [ 64-65-3 ]
  • cis-diaminediiodoplatinum(II) [ No CAS ]
  • silver nitrate [ No CAS ]
  • cis-[Pt2(3-ethyl-3-methylglutarimidate)2(NH3)4](NO3)2 (H-H) [ No CAS ]
  • 33
  • [ 7631-99-4 ]
  • [ 64-65-3 ]
  • cis-diaminediiodoplatinum(II) [ No CAS ]
  • cis-[Pt2(3-ethyl-3-methylglutarimidate)2(NH3)4](NO3)2 (H-H) [ No CAS ]
  • 34
  • [ 6940-78-9 ]
  • [ 64-65-3 ]
  • [ 1417033-91-0 ]
YieldReaction ConditionsOperation in experiment
51% With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20℃; General procedure: To a suspension of corresponding cyclic imide 1a-1k (4mmol), potassium carbonate (4.4mmol) in DMF (5mL), 1-bromo-4-chlorobutane (1,2-dibromoethane (5 eq) for 2l, 1-bromo-3-chloropropane for 2m, 1-bromo-5-chloropentane for 2n) (4.4mmol) was added dropwise at 0C. The mixture was stirred at room temperature overnight and then partitioned between ethyl acetate (EA, 20mL) and water (30mL). The organic layer was washed successively with water (3×30mL), saturated brine, and dried over anhydrous Na2SO4. The solvent was evaporated under vacuum and the residue was purified by column chromatography using petroleum ether(PE): EA (8:1) as eluent to give 2a-2n.
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  • [ 64-65-3 ]
  • 1-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-4-ethyl-4-methylpiperidine-2,6-dione hydrochloride [ No CAS ]
 

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