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Chemical Structure| 86541-75-5 Chemical Structure| 86541-75-5

Structure of Benazepril
CAS No.: 86541-75-5

Chemical Structure| 86541-75-5

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Benazepril is an ACE inhibitor, primarily used in treatment of hypertension.

Synonyms: Benazepril

4.5 *For Research Use Only !

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Product Details of Benazepril

CAS No. :86541-75-5
Formula : C24H28N2O5
M.W : 424.49
SMILES Code : O=C(O)CN1C2=CC=CC=C2CC[C@H](N[C@@H](CCC3=CC=CC=C3)C(OCC)=O)C1=O
Synonyms :
Benazepril
MDL No. :MFCD00864466
InChI Key :XPCFTKFZXHTYIP-PMACEKPBSA-N
Pubchem ID :5362124

Safety of Benazepril

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • ACE

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00000620 Atherosclerosis ... More >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease Less << Phase 3 Completed - United States, Minnesota ... More >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada Less <<
NCT00000620 - Completed - -
NCT01076205 - Completed - -
NCT01715584 Hypertension Phase 4 Recruiting December 31, 2019 Canada, Ontario ... More >> London Health Sciences Centre - Victoria Campus Recruiting London, Ontario, Canada, N6A 5W9 Contact: Craig J Railton, MD, PhD    519 685 8500 ext 58525    Craig.Railton@lhsc.on.ca    Principal Investigator: Craig J Railton, MD, PhD          Sub-Investigator: Jonathan Fairbairn, BSc          Sub-Investigator: George Nicoloau, MD          Sub-Investigator: Robert Gros, PhD          Sub-Investigator: Jason Franklin, MD          Sub-Investigator: John Yoo, MD          Sub-Investigator: Kevin Fung, MD          Sub-Investigator: Anthony Nichols, MD          Sub-Investigator: Danielle McNeil, MD Less <<
NCT01669434 Hypotension on Induction Phase 4 Completed - United States, Nebraska ... More >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Less <<
NCT01669434 - Completed - -
NCT00684489 Hypertension Not Applicable Completed - -
NCT01867047 - Terminated(Following an interi... More >>m analysis the study team felt that there was enough data that showed no significant difference.) Less << - -
NCT00691314 Stroke Transi... More >>ent Ischemic Attack Atherosclerosis Stenosis Stents Less << Not Applicable Completed - China, Beijing ... More >> Beijing Tiantan Hospital Beijing, Beijing, China, 100050 Xuanwu Hospital Capital Medical University Beijing, Beijing, China, 100053 Peking Union Medical College Hospital Beijing, Beijing, China, 100730 China, Chongqing Southwest Hospital Chongqing, Chongqing, China, 400038 Daping Hospital Chongqing, Chongqing, China, 400042 China, Jiangsu Nanjing General Hospital of Nanjing Military Command Nanjing, Jiangsu, China, 210002 China, Jilin Jilin University Changchun, Jilin, China, 130021 China, Shanghai Huashan Hospital Fudan University Shanghai, Shanghai, China, 200040 China, Sichuan West China Center of Medical Sciences Chengdu, Sichuan, China, 610041 China, Tianjin The General Hospital Under Tianjin Medical Sciences University Tianjin, Tianjin, China, 300052 Less <<
NCT00185120 Hypertension Phase 4 Completed - United States, Alabama ... More >> Mobile, Alabama, United States, 36693 United States, California Memorial Research Medical Center Long Beach, California, United States, 90806 National Research Institute Los Angeles, California, United States, 90057 Clinical Trials Research Roseville, California, United States, 95661 Apex Research Institute Santa Ana, California, United States, 92705 Orange County Research Center Tustin, California, United States, 92780 Westlake Medical Center Westlake Village, California, United States, 91361 United States, Florida Clinical Research of South Florida Coral Gables, Florida, United States, 33134 The Greater Fort Lauderdale Heart Group Research Fort lauderdale, Florida, United States, 33308 SFBC International Miami, Florida, United States, 33142 CLIRECO, Inc. Tamarac, Florida, United States, 33321 United States, Indiana Midwest Institute for Clinical Research Indianapolis, Indiana, United States, 46260 United States, Kansas Heartland Research Associates Wichita, Kansas, United States, 67207 United States, Maine Androscoggin Cardiology Research Auburn, Maine, United States, 04210 United States, North Carolina Internal Medicine Associates of Charlotte Charlotte, North Carolina, United States, 28211 Piedmont Medical Research Associates Winston-salem, North Carolina, United States, 27103 United States, Ohio The Lindner Clinical Trial Center Cincinnati, Ohio, United States, 45319 United States, Rhode Island Omega Medical Research Warwick, Rhode Island, United States, 02886 United States, Tennessee Volunteer Research Group, University of Tennessee Med. Ctr. Knoxville,, Tennessee, United States, 37920 United States, Texas Punzi Medical Center Carrollton, Texas, United States, 75006 Less <<
NCT01867047 Adverse Effects of Angiotensin... More >>-converting-enzyme Inhibitors Hypotension Less << Not Applicable Terminated(Following an interi... More >>m analysis the study team felt that there was enough data that showed no significant difference.) Less << - United States, North Carolina ... More >> Duke University Durham, North Carolina, United States, 27710 Less <<
NCT00961207 Microalbuminuria ... More >> Macroalbuminuric Diabetic Nephropathy Diabetes Proteinuria Albuminuria Less << Phase 4 Terminated(Altitude trial whic... More >>h used similar drugs was terminated due to increased ADR.) Less << - United States, Illinois ... More >> John H Stroger Hospital of Cook County Chicago, Illinois, United States, 60612 Less <<
NCT02532777 Henoch-Schoenlein Purpura Neph... More >>ritis Less << Phase 2 Recruiting July 2020 China, Jiangsu ... More >> Nanjing Children's Hospital Recruiting Nanjing, Jiangsu, China, 210000 Contact: Aihua Zhang, M.D.    +8618951769017    bszah@163.com Less <<
NCT03591471 Henoch-Sch?nlein Purpura Nephr... More >>itis Less << Phase 1 Phase 2 Recruiting December 2018 China, Henan ... More >> Children's Hospital, The First Affiliated Hospital of HUTCM Recruiting Zhengzhou, Henan, China, 450000 Contact: Ying Ding, Director    +86-13503840642    dingying3236@sina.com    Contact: Xia Zhang, secretary    +86-13838276039    zhangxia_125@163.com    Principal Investigator: Ying Ding, Director          The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Recruiting Zhengzhou, Henan, China, 450000 Contact: Ying Ding, MD    +86-371-66221361    dingying3236@sina.com    Contact: Xia zhang, MD    +86-371-13213210370    ardar123@sina.com    Principal Investigator: Jiansheng Li, MD Less <<
NCT00309257 Alport Syndrome Phase 2 Completed - Italy ... More >> Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Less <<
NCT03682692 Hypertension Phase 4 Recruiting December 2019 China ... More >> Shanghai Institite of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Recruiting Shanghai, China, 200025 Contact: Jiguang Wang, MD, PhD    86-21-64370045 ext 610911    jiguang_wang_jgw@yahoo.com Less <<
NCT00664846 Stroke Not Applicable Completed - -
NCT02532790 Henoch-Schoenlein Purpura Neph... More >>ritis Less << Phase 2 Recruiting July 2020 China, Jiangsu ... More >> Nanjing Children's Hospital Recruiting Nanjing, Jiangsu, China, 210000 Contact: Aihua Zhang, M.D.    +8618951769017    bszah@163.com Less <<
NCT01375322 Hypertension ... More >>Diabetes Mellitus, Type 2 Albuminuria Less << Phase 4 Completed - Taiwan ... More >> Chang Gung Memorial Hospital-Kaohsiung Kaohsiung, Taiwan, 833 Taichung Veterans General Hospital Taichung, Taiwan, 407 Tri-Service General Hospital Taipei, Taiwan, 114 Far Eastern Memorial Hospital Taipei, Taiwan, 220 Less <<
NCT00494715 Diabetes Phase 3 Completed - Italy ... More >> Clinical Research Center for Rare Diseases "Aldo e Cele Daccò" Ranica, Bergamo, Italy Hospital "Bolognini" Seriate, Bergamo, Italy Hospital "S.Marta e S.Venera" Acireale, Catania, Italy Hospital " Casa Sollievo della Sofferenza" - Unit of Nephrology San Giovanni Rotondo, Foggia, Italy Hospital "Azienda Ospedaliera Ospedali Riuniti di Bergamo" - Unit of Diabetology Bergamo, Italy Hospital "Vittorio Emanuele-Ferrarotto-Santo Bambino" Catania, Italy IRCCS San Raffaele - Unit of General Medicine Milan, Italy University "Federico II" Napoli, Italy Hospital "Azienda Ospedaliera di Parma" - Unit of Nephrology Parma, Italy Hospital "Azienda Ospedaliera di Treviglio e Caravaggio" - Ambulatory of Ponte San Pietro Ponte San Pietro, Italy Hospital "Azienda Ospedaliera di Treviglio e Caravaggio" Unit of Diabetology and Metabolic Diseases Romano di Lombardia, Italy University - AUSL 1 - Institute of Medical Pathology Sassari, Italy Hospital "G:Mazzini" Teramo, Italy Hospital "Azienda Ospedaliera di Treviglio-Caravaggio"Unit of Diabetology and Metabolic Diseases Treviglio, Italy Slovenia Clinical Department of Endocrinology, Diabetes and Metabolic Diseases University Medical Centre Ljubljana Ljubljana, Slovenia, 1000 Less <<
NCT01234922 Hypertension ... More >>Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 2 Terminated(slow accrual) - United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Less <<
NCT01234922 - Terminated(slow accrual) - -
NCT01917149 Dilated Cardiomyopathy Phase 4 Completed - China ... More >> Xijing Hospital, Department of Cardiology Xi'an, China, 710032 Less <<
NCT00170950 Hypertension Phase 3 Terminated(The study was termi... More >>nated early because of significant efficacy results for the primary endpoint in favor of benazepril/amlodipine treatment.) Less << - United States, New Jersey ... More >> Novartis Pharmaceuticals E. Hanover, New Jersey, United States, 07936 Denmark sites in Denmark Denmark, Denmark Finland sites in Finland Finland, Finland Norway sites in Norway Norway, Norway Sweden sites in Sweden Sweden, Sweden Less <<
NCT00338091 Renal Insufficiency,Chronic ... More >> Disease Progression Proteinuria Dose-Response Relationship,Drug ACE Inhibitor Angiotensin II Type 1 Receptor Blockers Less << Not Applicable Terminated - China, Guangdong ... More >> Renal Division, Nanfang Hospital,Southern Medical University Guangzhou, Guangdong, China, 510515 Less <<
NCT00721773 Renal Function Disorder Not Applicable Completed - China, Guangdong ... More >> The 1st Affiliated Hospital, Sun Yet-sen University GuangZhou, Guangdong, China, 510080 Less <<
NCT00171119 Hypertension ... More >>Diabetic Nephropathy Less << Phase 4 Terminated - Switzerland ... More >> Novartis Pharmaceuticals Basel, Switzerland Less <<
NCT00170950 - Terminated(The study was termi... More >>nated early because of significant efficacy results for the primary endpoint in favor of benazepril/amlodipine treatment.) Less << - -
NCT00630708 Renal Insufficiency, Chronic Not Applicable Terminated(Significant differe... More >>nces observed between groups.) Less << - China, Guangdong ... More >> Renal Division, Nanfang Hospital,Southern Medical University Guangzhou, Guangdong, China, 510515 Less <<
NCT00234871 Hypertension ... More >>Diabetes Proteinuria Less << Phase 4 Completed - -
NCT00503152 Diabetes Phase 3 Completed - Italy ... More >> Hospital "Azienda Ospedaliera di Treviglio e Caravaggio" - Diabetologic Ambulatory of Ponte San Pietro Ponte San Pietro, Bergamo, Italy Clinical Research Center for Rare Diseases "Aldo e Cele Daccò" Ranica, Bergamo, Italy Hospital "Azienda Ospedaliera di Treviglio e Caravaggio" Unit of Diabetology and Metabolic Diseases Romano di Lombardia, Bergamo, Italy Hospital "Bolognini" Seriate, Bergamo, Italy Hospital "Azienda Ospedaliera di Treviglio-Caravaggio"Unit of Diabetology and Metabolic Diseases Treviglio, Bergamo, Italy Hospital "Casa Sollievo della Sofferenza" - Division of Endocrinology San Giovanni Rotondo, Foggia, Italy Hospital "Azienda Ospedaliera Ospedali Riuniti di Bergamo" - Unit of Diabetology Bergamo, Italy IRCCS San Raffaele - Unit of General Medicine Milano, Italy Azienda USL 2 Olbia, Italy Less <<
NCT00907374 - Completed - -
NCT00139555 Hypertension ... More >>Left Ventricular Hypertrophy Less << Phase 4 Completed - United States, New Jersey ... More >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Less <<
NCT00136773 Albuminuria Phase 4 Completed - -
NCT00836576 Healthy Phase 1 Completed - United States, Missouri ... More >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 Less <<
NCT00270426 Chronic Kidney Failure TERMINATED - -
NCT00136851 Hypertension Phase 4 Completed - United States, New Jersey ... More >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Less <<
NCT00171366 Hypertension Phase 3 Completed - United States, New Jersey ... More >> Novartis Pharmaceuticals E. Hanover, New Jersey, United States, 07936 Less <<
NCT00649402 Healhty Phase 1 Completed - United States, West Virginia ... More >> Kendle International Inc. Morgantown, West Virginia, United States, 26505 Less <<
NCT00836537 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less <<
NCT01095939 Renal Alteration Phase 3 Completed - Switzerland ... More >> Geneva University Hospitals Geneva, Switzerland Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland Less <<
NCT00367978 Hypertension Phase 4 Completed - United States, New Jersey ... More >> Novartis Pharmaceuticals Corporation East Hanover, New Jersey, United States, 07936 Less <<
NCT00649519 Healthy Phase 1 Completed - United States, West Virginia ... More >> Kendle International Inc. Morgantown, West Virginia, United States, 26505 Less <<
NCT00907374 Microalbuminuria Not Applicable Completed - United States, California ... More >> Charles Drew University Los Angeles, California, United States, 90059 Less <<
NCT00649038 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less <<
NCT00367094 Hypertension Phase 3 Completed - China ... More >> Novartis Beijing, China Less <<
NCT00649597 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less <<
NCT00834977 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Montreal, Quebec, Canada, H3X H29 SFBC Anapharm Sainte-Foy, Quebec, Canada, G1V 2K8 Less <<
NCT00834977 - Completed - -
NCT00835367 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Montreal, Quebec, Canada, H2X 2H9 SFBC Anapharm Sainte-Foy, Quebec, Canada, G1V 2K8 Less <<
NCT00835367 - Completed - -
NCT00778726 Healthy Not Applicable Completed - United States, North Carolina ... More >> aaiPharma, Inc Chapel Hill, North Carolina, United States, 27517 Less <<
NCT01155895 Healthy Phase 1 Completed - -
NCT01155908 Healthy Phase 1 Completed - -
NCT00778674 Healthy Not Applicable Completed - United States, North Carolina ... More >> aaiPharma, Inc. Chapel Hill, North Carolina, United States, 27517 Less <<
NCT01506011 Fasting Phase 1 Completed - India ... More >> Vimta Labs Ltd. Hyderabad, A.P, India, 500 051 Less <<
NCT01505998 Fed Phase 1 Completed - India ... More >> Vimta Labs Ltd. Hyderabad, A.P, India, 500 051 Less <<
NCT01603940 Hypertension ... More >>Diabetes Mellitus Less << Phase 4 Completed - Brazil ... More >> Hospital Universitario Pedro Ernesto Rio de Janeiro, RJ, Brazil, 20551030 Less <<
NCT01603940 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

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