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Chemical Structure| 94-18-8 Chemical Structure| 94-18-8

Structure of Benzyl 4-Hydroxybenzoate
CAS No.: 94-18-8

Chemical Structure| 94-18-8

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Benzyl 4-Hydroxybenzoate is an important material used as a pharmaceutical excipient, such as an antimicrobial agent and preservative. Pharmaceutical excipients improve the stability, solubility, and processability of drug formulations, potentially affecting the absorption, distribution, metabolism, and elimination processes of drugs.

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Product Citations

Product Citations

Sen, Sajal ; Dawson, Miranda ; Thiabaud, Gregory D ; Backman, Kyle ; Fayer, Itay ; Das, Sayani , et al.

Abstract: Cholinesterase (ChE) enzymes terminate action of the neurotransmitter acetylcholine at synapses and neuromuscular junctions throughout the body. Noninvasive strategies for monitoring these enzymes could be important for studying basic biology of cholinergic systems and disorders that affect their function. To address this goal, we developed an imaging probe that allows activity of ChE to be detected using MRI. The probe, called ChERT, undergoes enzymatic processing that reduces its solubility, promoting accumulation near sites of cholinesterase activity. Following wide-field brain delivery, ChERT produces MRI contrast changes in brain regions known to be enriched in cholinesterases; these are suppressed in the presence of a selective enzymatic inhibitor, confirming their specificity. After abdominal delivery, ChERT labels regions of the gut where ChE expression is expected. In both the brain and periphery, colocalization of ChERT with ChE could be confirmed and visualized at higher resolution by fluorescence microscopy, owing to optical properties of the probe architecture. The ChERT agent thus provides a potentially versatile basis for assessment of cholinergic phenotypes throughout the body.

Keywords: molecular imaging ; contrast agent ; brain ; peripheral nervous system ; neurochemistry

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Product Details of Benzyl 4-Hydroxybenzoate

CAS No. :94-18-8
Formula : C14H12O3
M.W : 228.24
SMILES Code : O=C(OCC1=CC=CC=C1)C2=CC=C(O)C=C2
MDL No. :MFCD00016471
InChI Key :MOZDKDIOPSPTBH-UHFFFAOYSA-N
Pubchem ID :7180

Safety of Benzyl 4-Hydroxybenzoate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H319-H372-H410
Precautionary Statements:P501-P273-P260-P270-P264-P280-P391-P314-P337+P313-P305+P351+P338-P301+P312+P330
Class:9
UN#:3077
Packing Group:

Isoform Comparison

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.38mL

0.88mL

0.44mL

21.91mL

4.38mL

2.19mL

43.81mL

8.76mL

4.38mL

 

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