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Chemical Structure| 1392399-03-9 Chemical Structure| 1392399-03-9

Structure of BIX-01294 3HCl
CAS No.: 1392399-03-9

Chemical Structure| 1392399-03-9

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BIX-01294 trihydrochloride is a reversible and highly selective G9a and GLP histone methyltransferase inhibitor, with IC50s of 1.7 μM and 0.9 μM, respectively. It inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. As a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, BIX-01294 trihydrochloride induces necroptosis and autophagy, and exhibits antitumor activity in recurrent tumor cells.

Synonyms: BIX 01294; BIX-01294 trihydrochloride

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Product Details of BIX-01294 3HCl

CAS No. :1392399-03-9
Formula : C28H41Cl3N6O2
M.W : 600.02
SMILES Code : COC1=CC2=NC(N3CCN(C)CCC3)=NC(NC4CCN(CC5=CC=CC=C5)CC4)=C2C=C1OC.[H]Cl.[H]Cl.[H]Cl
Synonyms :
BIX 01294; BIX-01294 trihydrochloride
MDL No. :MFCD16618384
InChI Key :FMURUEPQXKJIPS-UHFFFAOYSA-N
Pubchem ID :46945860

Safety of BIX-01294 3HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of BIX-01294 3HCl

epigenetics

Isoform Comparison

Biological Activity

Target
  • Histone Methyltransferase

    G9a, IC50:2.7 μM

Protocol

Bio Calculators
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1 mM

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1.67mL

0.33mL

0.17mL

8.33mL

1.67mL

0.83mL

16.67mL

3.33mL

1.67mL

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