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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 623152-17-0 Chemical Structure| 623152-17-0

Structure of BMS-582949
CAS No.: 623152-17-0

Chemical Structure| 623152-17-0

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BMS-582949 is an orally active, highly selective p38α MAP kinase inhibitor with an IC50 of 13 nM for p38α and 50 nM for TNFα. It can be used in the study of rheumatoid arthritis.

Synonyms: PS540446

4.5 *For Research Use Only !

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Product Details of BMS-582949

CAS No. :623152-17-0
Formula : C22H26N6O2
M.W : 406.48
SMILES Code : O=C(C1=CN2N=CN=C(NC3=CC(C(NC4CC4)=O)=CC=C3C)C2=C1C)NCCC
Synonyms :
PS540446
MDL No. :N/A

Safety of BMS-582949

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H360-H373
Precautionary Statements:P264-P270-P301+P312-P330-P501-P201-P202-P308+P313
Class:6.1
UN#:2811
Packing Group:

Related Pathways of BMS-582949

MAPK
TLR

Isoform Comparison

Biological Activity

Target
  • p38 MAPK

    p38 MAPK, IC50:13 nM

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Rats Subarachnoid hemorrhage model Intraperitoneal injection 100 mg/kg Single administration BMS-582949 significantly decreased the protein expression levels of p-p38, significantly downregulated the expression levels of oxidative stress and apoptosis-associated proteins, but had no significant effect on the protein expression levels of p-ASK1, ASK1, or p-JNK. PMC9879074

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.46mL

0.49mL

0.25mL

12.30mL

2.46mL

1.23mL

24.60mL

4.92mL

2.46mL

References

 

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