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Chemical Structure| 1000998-59-3 Chemical Structure| 1000998-59-3

Structure of BMS-687453
CAS No.: 1000998-59-3

Chemical Structure| 1000998-59-3

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BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.

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Product Details of BMS-687453

CAS No. :1000998-59-3
Formula : C22H21ClN2O6
M.W : 444.87
SMILES Code : ClC(C=C1)=CC=C1C2=NC(COC3=CC=CC(CN(C(OC)=O)CC(O)=O)=C3)=C(C)O2
MDL No. :MFCD18251482
InChI Key :UJIBXDMNCMEJAY-UHFFFAOYSA-N
Pubchem ID :16725047

Safety of BMS-687453

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Murine mesangial cells (MMCs) 426 nM 48 h To validate whether PPARα activation stimulated PAI-1 expression, it was found that after stimulating PPARα activity with BMS-687453 (a PPARα agonist), the downregulated PAI-1 expression by LLPS treatment was partially reversed, confirming that PPARα activity directly affects PAI-1 expression. Am J Transl Res. 2019 Jun 15;11(6):3531-3542

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.24mL

2.25mL

1.12mL

22.48mL

4.50mL

2.25mL

References

 

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