Boc-Nva-OH | N-protective Amino Acid

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Quality Control of Boc-Nva-OH Purity: 98% SDS Specification

COA

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NMR

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CNMR

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HPLC

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LC-MS

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Product Details of Boc-Nva-OH

CAS No. :	53308-95-5
Formula :	C₁₀H₁₉NO₄
M.W :	217.26
SMILES Code :	C(=O)(N[C@H](C(=O)O)CCC)OC(C)(C)C
MDL No. :	MFCD00037268
InChI Key :	INWOAUUPYIXDHN-ZETCQYMHSA-N
Pubchem ID :	2733748

Safety of Boc-Nva-OH

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of Boc-Nva-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 53308-95-5 ]

[ 53308-95-5 ] Synthesis Path-Downstream 1~35

1
(+)-pinanediol 1-chloro-pentyl-1-boronate hydrochloride [ No CAS ]
[ 53308-95-5 ]
{(S)-1-[(R)-1-((1S,2S,6R,8S)-2,9,9-Trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]dec-4-yl)-pentylcarbamoyl]-butyl}-carbamic acid tert-butyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 4256 - 4260.

2
[ 53308-95-5 ]
[ 151-63-3 ]
[1-(cyanomethyl-carbamoyl)-butyl]-carbamic acid tert-butyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 7688 - 7707.

3
[ 53308-95-5 ]
[ 530-62-1 ]
[1-(imidazole-1-carbonyl)-butyl]-carbamic acid tert-butyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 544 - 559.
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 9396 - 9408.

4
[ 53308-95-5 ]
[ 74-88-4 ]
[ 64896-37-3 ]

References: [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 3385 - 3396.
[2]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 544 - 559.

5
[ 53308-95-5 ]
[ 78-81-9 ]
(1-isobutylcarbamoyl-butyl)-carbamic acid tert-butyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 3635 - 3638.

6
[ 186581-53-3 ]
[ 53308-95-5 ]
[ 64896-37-3 ]

References: [1]Tetrahedron Asymmetry,2006,vol. 17,p. 1995 - 1999.

7
1-(6-phenylhexyl)-4-piperidone [ No CAS ]
Rink-isonitrile resin [ No CAS ]
[ 107-10-8 ]
[ 53308-95-5 ]
(S)-9-(6-Phenyl-hexyl)-1,3-dipropyl-1,4,9-triaza-spiro[5.5]undecane-2,5-dione [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 4145 - 4152.

8
[ 53308-95-5 ]
[ 116611-57-5 ]

Yield	Reaction Conditions	Operation in experiment
96%	With borane; In tetrahydrofuran; methanol;	Step 1. Preparation of Boc-Norvalinol: To a solution of Boc-norvaline (25.0 g, 0.115 mol) in tetrahydrofuran (461 mL), cooled to 0° C., was added borane/tetrahydrofuran complex (461 mL of a 1.0M solution in tetrahydrofuran) dropwise. After 1 h at 0° C., the solution was warmed to room temperature over a period of 1.5 h. TLC indicated that the reaction was complete. Methanol was added to quench the reaction. The solution was concentrated to yield the title compound (22.56 g, 96percent) as a foamy syrup. TLC of the products indicated satisfactory purity. Rf=0.34 (40percent ethyl acetate/hexanes).

References: [1]Patent: US2003/216325,2003,A1 .
[2]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 6789 - 6806.
[3]Bioorganic and medicinal chemistry letters,2004,vol. 14,p. 275 - 278.

9
[ 142729-70-2 ]
[ 53308-95-5 ]
[ 116611-58-6 ]