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Chemical Structure| 16503-32-5 Chemical Structure| 16503-32-5

Structure of Brevilin A
CAS No.: 16503-32-5

Chemical Structure| 16503-32-5

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Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).

Synonyms: 6-O-Angeloylprenolin; 6-O-Angeloylplenolina; 6-O-Angeloylplenolin

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Product Details of Brevilin A

CAS No. :16503-32-5
Formula : C20H26O5
M.W : 346.42
SMILES Code : C/C=C(C)\C(O[C@@H]([C@@]([C@@H]1C)([H])[C@]2([H])OC1=O)[C@]3(C)C(C=C[C@@]3([H])[C@H](C)C2)=O)=O
Synonyms :
6-O-Angeloylprenolin; 6-O-Angeloylplenolina; 6-O-Angeloylplenolin
MDL No. :MFCD04034623
InChI Key :KUPPZVXLWANEJJ-UXPPPGSFSA-N
Pubchem ID :12302076

Safety of Brevilin A

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Brevilin A

JAK-STAT

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.89mL

0.58mL

0.29mL

14.43mL

2.89mL

1.44mL

28.87mL

5.77mL

2.89mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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