Structure of Bryostatin 1
CAS No.: 83314-01-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Bryostatin 1 is a Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM).
Synonyms: NSC 339555
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CAS No. : | 83314-01-6 |
Formula : | C47H68O17 |
M.W : | 905.03 |
SMILES Code : | O[C@](O[C@@](C[C@](OC(C[C@@H](C[C@@]1([H])O2)O)=O)([H])[C@H](O)C)([H])C/C3=C\C(OC)=O)(C(C)(/C=C/[C@](C/C4=C\C(OC)=O)([H])O[C@](C4)([H])C[C@]2(C(C)([C@@H](OC(C)=O)C1)C)O)C)[C@H]3OC(/C=C/C=C/CCC)=O |
Synonyms : |
NSC 339555
|
MDL No. : | MFCD00893832 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00006081 | Esophageal Cancer ... More >> Gastric Cancer Less << | Phase 2 | Completed | - | United States, Texas ... More >> CCOP - M.D. Anderson Research Base Houston, Texas, United States, 77030-4009 University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Less << |
NCT00003242 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00003108 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, District of Col... More >>umbia Lombardi Cancer Center Washington, District of Columbia, United States, 20007 Less << |
NCT00012376 | Accelerated Phase Chronic Myel... More >>ogenous Leukemia Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Blastic Phase Chronic Myelogenous Leukemia Chronic Myelomonocytic Leukemia Chronic Phase Chronic Myelogenous Leukemia Paroxysmal Nocturnal Hemoglobinuria Previously Treated Myelodysplastic Syndromes Recurrent Adult Acute Myeloid Leukemia Refractory Anemia Refractory Anemia With Ringed Sideroblasts Relapsing Chronic Myelogenous Leukemia Thrombocytopenia Untreated Adult Acute Myeloid Leukemia Less << | Phase 1 | Completed | - | United States, Maryland ... More >> Johns Hopkins University Baltimore, Maryland, United States, 21287-8936 Less << |
NCT00003993 | Lymphoma Smal... More >>l Intestine Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, Maryland ... More >> National Institute on Aging - Baltimore Baltimore, Maryland, United States, 21224-6825 Less << |
NCT00005599 | Esophageal Cancer ... More >> Gastric Cancer Less << | Phase 2 | Completed | - | United States, New York ... More >> Albert Einstein Clinical Cancer Center Bronx, New York, United States, 10467 Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00005580 | Leukemia Lymp... More >>homa Less << | Phase 1 | Completed | - | United States, New York ... More >> New York Presbyterian Hospital - Cornell Campus New York, New York, United States, 10021 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 United States, Virginia Massey Cancer Center Richmond, Virginia, United States, 23298-0037 Less << |
NCT00006022 | Kidney Cancer ... More >> Melanoma (Skin) Less << | Phase 1 | Completed | - | United States, New Hampshire ... More >> Norris Cotton Cancer Center Lebanon, New Hampshire, United States, 03756-0002 United States, Virginia Massey Cancer Center Richmond, Virginia, United States, 23219 Less << |
NCT00003174 | Leukemia | Phase 1 | Completed | - | United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48202-1379 Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 Van Elslander Cancer Center at St. John Hospital and Medical Center Grosse Pointe Woods, Michigan, United States, 48236 Less << |
NCT00005965 | Cervical Cancer | Phase 2 | Completed | - | United States, New York ... More >> Albert Einstein Comprehensive Cancer Center Bronx, New York, United States, 10461 Saint Vincent Catholic Medical Center of New York New York, New York, United States, 10011 NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York, United States, 10016 New York Presbyterian Hospital - Cornell Campus New York, New York, United States, 10021 Mount Sinai Medical Center, NY New York, New York, United States, 10029 New York Medical College Valhalla, New York, United States, 10595 Less << |
NCT00017342 | Leukemia | Phase 2 | Completed | - | United States, New York ... More >> New York Weill Cornell Cancer Center at Cornell University New York, New York, United States, 10021 Herbert Irving Comprehensive Cancer Center at Columbia University New York, New York, United States, 10032 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 United States, Virginia Massey Cancer Center at Virginia Commonwealth University Richmond, Virginia, United States, 23298-0037 Less << |
NCT00003079 | Leukemia Lymp... More >>homa Less << | Phase 1 | Completed | - | United States, New York ... More >> New York Presbyterian Hospital - Cornell Campus New York, New York, United States, 10021 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030 United States, Virginia Massey Cancer Center Richmond, Virginia, United States, 23298-0037 Less << |
NCT00003132 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York, United States, 10016 Less << |
NCT00087425 | Leukemia Lymp... More >>homa Less << | Phase 2 | Completed | - | United States, Maryland ... More >> NIH - Warren Grant Magnuson Clinical Center Bethesda, Maryland, United States, 20892-1182 Less << |
NCT00005849 | Lung Cancer | Phase 2 | Completed | - | United States, Illinois ... More >> University of Illinois at Chicago Chicago, Illinois, United States, 60612 University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637 Louis A. Weiss Memorial Hospital Chicago, Illinois, United States, 60640 Decatur Memorial Hospital Cancer Care Institute Decatur, Illinois, United States, 62526 Evanston Northwestern Health Care Evanston, Illinois, United States, 60201 Lutheran General Cancer Care Center Park Ridge, Illinois, United States, 60068 Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois, United States, 61602 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62701 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46885-5099 Michiana Hematology/Oncology P.C. South Bend, Indiana, United States, 46617 Less << |
NCT00004008 | Ovarian Cancer | Phase 2 | Completed | - | United Kingdom ... More >> Christie Hospital N.H.S. Trust Manchester, England, United Kingdom, M20 4BX Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 9DU Weston Park Hospital Sheffield, England, United Kingdom, S1O 2SJ Royal Infirmary Glasgow, Scotland, United Kingdom, G4 0SF Less << |
NCT00005028 | Prostate Cancer | Phase 2 | Completed | - | United States, Maryland ... More >> Greater Baltimore Medical Center and Cancer Center Baltimore, Maryland, United States, 21204 United States, North Carolina Comprehensive Cancer Center at Wake Forest University Winston-Salem, North Carolina, United States, 27157-1082 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111-2497 Wellspan Health - York Cancer Center York, Pennsylvania, United States, 17403 Less << |
NCT00003205 | Breast Cancer | Phase 2 | Completed | - | United States, Colorado ... More >> University of Colorado Cancer Center Denver, Colorado, United States, 80010 Less << |
NCT00003443 | Head and Neck Cancer | Phase 2 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00003936 | Lymphoma | Phase 2 | Completed | - | United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less << |
NCT00002907 | Multiple Myeloma and Plasma Ce... More >>ll Neoplasm Less << | Phase 2 | Completed | - | United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less << |
NCT00003171 | Leukemia Myel... More >>odysplastic Syndromes Less << | Phase 2 | Completed | - | United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less << |
NCT00002908 | Leukemia Lymp... More >>homa Less << | Phase 2 | Completed | - | United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less << |
NCT00005056 | Kidney Cancer | Phase 2 | Completed | - | United Kingdom ... More >> Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 7LJ Imperial Cancer Research Fund Medical Oncology Unit Oxford, England, United Kingdom, OX3 7LJ Less << |
NCT00004144 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 Less << |
NCT00002725 | Lymphoma | Phase 2 | Completed | - | United States, Texas ... More >> University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00006389 | Stage III Gastric Cancer ... More >> Stage IV Gastric Cancer Less << | Phase 2 | Completed | - | United States, California ... More >> University of Southern California Los Angeles, California, United States, 90033-0804 Less << |
NCT00032188 | Recurrent Renal Cell Cancer ... More >> Stage III Renal Cell Cancer Stage IV Renal Cell Cancer Less << | Phase 2 | Completed | - | United States, Illinois ... More >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637-1470 Less << |
NCT00006942 | Fallopian Tube Cancer ... More >> Primary Peritoneal Cavity Cancer Recurrent Ovarian Epithelial Cancer Stage III Ovarian Epithelial Cancer Stage IV Ovarian Epithelial Cancer Less << | Phase 2 | Completed | - | United States, California ... More >> City of Hope Duarte, California, United States, 91010 Less << |
NCT00006389 | - | Completed | - | - | |
NCT00003166 | Recurrent Adult Burkitt Lympho... More >>ma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Multiple Myeloma Stage III Multiple Myeloma Less << | Phase 1 | Completed | - | United States, Ohio ... More >> Case Western Reserve University Cleveland, Ohio, United States, 44106 Less << |
NCT00136461 | Acute Myelogenous Leukemia ... More >> Myelodysplastic Syndrome Less << | Phase 2 | Completed | - | United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less << |
NCT00003968 | Kidney Cancer | Phase 2 | Completed | - | United States, New Jersey ... More >> Hunterdon Regional Cancer Center Flemington, New Jersey, United States, 08822 Kimball Medical Center Lakewood, New Jersey, United States, 08701 South Jersey Hospital - Millville Millville, New Jersey, United States, 08332 Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County Mount Holly, New Jersey, United States, 08060 Riverview Medical Center Red Bank, New Jersey, United States, 07701 Community Medical Center Toms River, New Jersey, United States, 08755 St. Francis Medical Center Trenton, New Jersey, United States, 08629 United States, Pennsylvania Bon Secours-Holy Family Health System Altoona, Pennsylvania, United States, 16602 Delaware County Memorial Hospital Drexel Hill, Pennsylvania, United States, 19026 Pinnacle Health Hospitals Harrisburg, Pennsylvania, United States, 17105-8700 Conemaugh Memorial Hospital Johnstown, Pennsylvania, United States, 15905 Saint Mary Medical Center Langhorne, Pennsylvania, United States, 19047 North Penn Hospital Lansdale, Pennsylvania, United States, 19446 Paoli Memorial Hospital Paoli, Pennsylvania, United States, 19301-1792 Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 Pottstown Memorial Regional Cancer Center Pottstown, Pennsylvania, United States, 19464 Reading Hospital and Medical Center Reading, Pennsylvania, United States, 19612-6052 Less << |
NCT00058305 | Extranodal Marginal Zone B-cel... More >>l Lymphoma of Mucosa-associated Lymphoid Tissue Nodal Marginal Zone B-cell Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Small Lymphocytic Lymphoma Splenic Marginal Zone Lymphoma Less << | Phase 2 | Completed | - | United States, Ohio ... More >> Case Western Reserve University Cleveland, Ohio, United States, 44106 Less << |
NCT00606164 | Alzheimer's Disease | Phase 2 | Unknown | December 2008 | United States, West Virginia ... More >> Chestnut Ridge Center West Virginia University Department of Behavioral Medicine and Psychiatry Not yet recruiting Morgantown, West Virginia, United States, 26505 Contact: Eric Rankin, Ph.D. 304-293-5323 erankin@hsc.wvu.edu Principal Investigator: James M Stevenson, MD Less << |
NCT00031694 | Acinar Cell Adenocarcinoma of ... More >>the Pancreas Duct Cell Adenocarcinoma of the Pancreas Recurrent Pancreatic Cancer Stage III Pancreatic Cancer Stage IV Pancreatic Cancer Less << | Phase 2 | Completed | - | United States, New York ... More >> Montefiore Medical Center Bronx, New York, United States, 10467-2490 Less << |
NCT00022555 | AIDS-related Diffuse Large Cel... More >>l Lymphoma AIDS-related Diffuse Mixed Cell Lymphoma AIDS-related Peripheral/Systemic Lymphoma AIDS-related Small Noncleaved Cell Lymphoma Less << | Phase 1 | Completed | - | United States, Maryland ... More >> AIDS - Associated Malignancies Clinical Trials Consortium Rockville, Maryland, United States, 20850 Less << |
NCT00112476 | Recurrent Melanoma ... More >> Recurrent Renal Cell Cancer Stage IV Melanoma Stage IV Renal Cell Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, Pennsylvania ... More >> Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111-2497 Less << |
NCT02431468 | Alzheimer's Disease | Phase 2 | Completed | - | - |
NCT02269605 | HIV Infection | Phase 1 | Completed | - | Spain ... More >> Infectious Diseases Service Madrid, Non US/Canada, Spain, 28034 Less << |
NCT02431468 | - | Completed | - | - | |
NCT02221947 | Alzheimer's Disease | Phase 1 Phase 2 | Terminated(Part 2 of study rep... More >>laced by NTRP-101-202, assessing 3 doses of bryostatin.) Less << | - | United States, California ... More >> California Clinical Trials Medical Center Glendale, California, United States, 91206 Less << |
NCT02221947 | - | Terminated(Part 2 of study rep... More >>laced by NTRP-101-202, assessing 3 doses of bryostatin.) Less << | - | - | |
NCT00003220 | Colorectal Cancer | Phase 2 | Completed | - | United States, Michigan ... More >> Veterans Affairs Medical Center - Detroit Detroit, Michigan, United States, 48201-1932 Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less << |
NCT00031694 | - | Completed | - | - | |
NCT03560245 | Alzheimer Disease | Phase 2 | Recruiting | July 30, 2019 | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.10mL 0.22mL 0.11mL |
5.52mL 1.10mL 0.55mL |
11.05mL 2.21mL 1.10mL |