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Chemical Structure| 35543-24-9 Chemical Structure| 35543-24-9
Chemical Structure| 35543-24-9

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Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease.

Synonyms: Buflomedil (hydrochloride); NSC 759291; LL-1656

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Product Details of Buflomedil HCl

CAS No. :35543-24-9
Formula : C17H26ClNO4
M.W : 343.85
SMILES Code : Cl.O=C(C=1C(OC)=CC(OC)=CC1OC)CCCN2CCCC2
Synonyms :
Buflomedil (hydrochloride); NSC 759291; LL-1656
MDL No. :MFCD00078965
InChI Key :ZDPACSAHMZADFZ-UHFFFAOYSA-N
Pubchem ID :6420013

Safety of Buflomedil HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Buflomedil HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35543-24-9 ]

[ 35543-24-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 621-23-8 ]
  • [ 713069-87-5 ]
  • [ 35543-24-9 ]
YieldReaction ConditionsOperation in experiment
60.2 g In a separate dry reaction flask, 33.6 g of 1,3,5-trimethoxybenzene and 27.2 g of anhydrous zinc chloride were added.Dichloromethane 300mL, stirring and cooling to 0-5 degrees after dropping 36.5g 1-pyrrolidinoyl chloride, drops,The reaction was heated to reflux for 2 hours. After the reaction was complete, 15 mL of concentrated hydrochloric acid and 150 mL of pure water were added and washed.The resulting organic phase is washed with saturated sodium bicarbonate solution to a pH of 7-8, and the organic phase is dried over magnesium sulfate and then reduced to dryness.Add 100 mL of anhydrous ethanol to the concentrate.20% hydrochloric acid ethanol100mLAfter stirring the reaction at 60-70C for 1 hour, the ethanol is then reduced to dryness.After adding 400 mL of acetone to the residue and cooling and crystallizing, the white crystal was filtered to obtain 60.2 g of buflomedil hydrochloride.
 

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