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Chemical Structure| 112898-15-4 Chemical Structure| 112898-15-4

Structure of BzATP triethylammonium salt
CAS No.: 112898-15-4

Chemical Structure| 112898-15-4

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Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.

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Product Details of BzATP triethylammonium salt

CAS No. :112898-15-4
Formula : C30H39N6O15P3
M.W : 816.58
SMILES Code : CCN(CC)CC.O=P(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O)[C@@H]1O)(O)OP(O)(OP(O)(O)=O)=O
MDL No. :MFCD00058547
InChI Key :HVOVBTNCGADRTH-WBLDMZOZSA-N
Pubchem ID :71308559

Safety of BzATP triethylammonium salt

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
MC3T3-E1 cells 300 µM 2 h Activate P2X7 receptor, promote ALP activity and OCN expression Mol Med Rep. 2019 Dec;20(6):5084-5090
Microglial cells 100 μM 10 min To investigate whether BzATP induces microglial cell permeabilization via P2X7 receptors. Results showed that BzATP at 100 μM induced accumulation of YO-PRO-1 in microglial cells, indicating P2X7 receptor activation leads to increased microglial cell permeabilization. J Neurosci. 2004 Sep 29;24(39):8577-83
Cells in the ganglion cell layer (GCL) and nerve fiber layer of rat retina 100 μM 10 min To investigate whether BzATP induces cell permeabilization via P2X7 receptors. Results showed that BzATP at 100 μM induced accumulation of YO-PRO-1 in the GCL and nerve fiber layer cells, indicating P2X7 receptor activation leads to increased cell permeabilization. J Neurosci. 2004 Sep 29;24(39):8577-83
Mouse parotid acinar cells 15 μM To investigate the effect of BzATP on chloride currents in mouse parotid acinar cells, results showed that BzATP activated a novel ATP-gated chloride channel distinct from known Ca2+-dependent, volume-sensitive, and inward-rectifier chloride channels. J Physiol. 2003 Feb 15;547(Pt 1):197-208

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