Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	32222-06-3
Formula :	C₂₇H₄₄O₃
M.W :	416.64
SMILES Code :	C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
Synonyms :	1,25-Dihydroxyvitamin D3; 1α,25-dihydroxy Vitamin D3; 1,25(OH)2D
MDL No. :	MFCD00867079

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H300+H310+H330-H361
Precautionary Statements:	P260-P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P403+P233
Class:	6.1
UN#:	2811
Packing Group:	Ⅰ

Primary cortical neurons	1 nM, 10 nM, 100 nM, 500 nM	24 h	To evaluate the effect of Calcitriol on neuronal cell viability. The results showed that 1 nM and 10 nM Calcitriol had no toxic effect, while 100 nM and 500 nM Calcitriol significantly reduced cell viability.	PMC8461874
AC16 cells	10 nM	24 h	To study the effect of Calcitriol on TNF-α-induced AC16 cell death, results showed that Calcitriol significantly increased cell viability.	PMC9139780
AC16 cells	100 nM	24 h	To study the effect of Calcitriol on TNF-α-induced AC16 cell death, results showed that high-dose Calcitriol significantly increased cell viability.	PMC9139780
SW480 cells	100 nM		Calcitriol inhibited the proliferation and migration capacity of SW480 cells	PMC8635240
LoVo cells	100 nM		Calcitriol inhibited the proliferation and migration capacity of LoVo cells	PMC8635240
FHC cells	100 nM		Calcitriol promoted the proliferation of FHC cells	PMC8635240
HL-1 atrial myocytes	1 nM and 10 nM	48 h	To investigate whether Calcitriol downregulates FGFR1 expression through histone deacetylase (HDAC) activation. Results showed that Calcitriol significantly reduced FGFR1 expression in HL-1 cells.	PMC5960138
osteoclast	1 nM, 10 nM, 100 nM	overnight	Calcitriol inhibited the fusion ability and the number of TRAP-positive differentiated osteoclasts in a dose-dependent manner.	PMC6164019
preosteoblast 7F2 cells	1 nM, 10 nM, 100 nM	overnight	Calcitriol had no significant effect on Wnt 10b and Wnt 16 expression in preosteoblast 7F2 cells.	PMC6164019

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CAS No.: 32222-06-3

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CAS No.: 32222-06-3

Alternative Products

Product Details of Calcitriol

Safety of Calcitriol

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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CD1 Elite mice	Traumatic brain injury (TBI) model	Gavage	0.5 µg/kg, 1 µg/kg, 3 µg/kg	Once daily for 14 days	To evaluate the neuroprotective effects of Calcitriol in TBI mice. The results showed that Calcitriol significantly ameliorated neurological deficits and histopathological changes following TBI, promoted the autophagic process, and activated Nrf2 signaling, thereby mitigating TBI-induced oxidative damage.	PMC8461874
C57BL/6 mice	4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis model	Intraperitoneal injection	0.1 μg	Monday, Wednesday, and Friday for 16 weeks, 10 weeks, or 26 weeks	To evaluate the impact of Calcitriol on oral carcinogenesis at different stages of intervention and durations of exposure. Results showed that Calcitriol administered concurrently with 4NQO for 16 weeks significantly reduced premalignant lesions by 57%, while 26 weeks of Calcitriol treatment showed the highest renal CYP24A1 expression and the highest incidence of invasive SCC.	PMC6416727
Kunming mice	Myocardial infarction model	Oral gavage	0.0375 µg/kg, 0.075 µg/kg, 0.15 µg/kg	Once daily for 4 weeks	To study the effect of Calcitriol on cardiac function and remodeling in MI mice, results showed that Calcitriol significantly improved cardiac function and reversed adverse cardiac remodeling.	PMC9139780
nude mice	SW480 cell-derived xenograft model	intraperitoneal injection	50 μg/kg	three times a week for 2 weeks	Calcitriol significantly inhibited the growth of SW480 cell-derived xenograft tumors	PMC8635240
C57BL/6J mice	5/6 nephrectomy CKD model	oral gavage	25 IU/kg, 150 IU/kg	daily for one month	Calcitriol significantly promoted the growth of both trabecular and cortical bone in CKD mice, especially at the 150 IU/kg dose.	PMC6164019

NCT03748966	X-linked Hypophosphatemia\|Hypo... More >>phosphatemic Rickets\|Hypophosphatemic Rickets, X-Linked Dominant Less <<	EARLY_PHASE1	RECRUITING	2025-03-25	Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States Less <<
NCT01120119	Diabetes Mellitus, Type 1	PHASE2	COMPLETED	-	University Campus Bio Medico, ... More >>Rome, 00128, Italy\|Bambino Gesù Children's Hospital, Rome, Italy\|Catholic University,, Rome, Italy\|Sandro Pertini Hospital, Rome, Italy\|University Sapienza, Rome, Italy Less <<
NCT01237028	IgA Nephropathy		COMPLETED	2025-08-16	National Health Insurance Corp... More >>oration Ilsan Hospital, Goyang, 41-0719, Korea, Republic of\|Kwandong University Myongji Hospital, Goyang, 412-270, Korea, Republic of\|Wongkwang University Sanbon Medical Center, Gunpo, 435-040, Korea, Republic of\|CHA University Bundang Medical Center, Seongnam, 435-040, Korea, Republic of\|Seoul National University Hospital, Seoul, 110-752, Korea, Republic of\|Severance Hospital, Seoul, 120-752, Korea, Republic of\|Ewha Womans University Medical Center, Seoul, 158-710, Korea, Republic of Less <<
NCT00319761	IGA Nephropathy	PHASE4	COMPLETED	2025-09-07	Department of Medicine & Thera... More >>peutics, Prince of Wales Hospital, Hong Kong, Hong Kong Less <<
NCT02125279	Psoriasis Vulgaris	PHASE4	COMPLETED	2025-05-18	Johnson Dermatology, Fort Smit... More >>h, Arkansas, 72916, United States\|Northwest Arkansas Clinical Trials Center, PLLC, Rogers, Arkansas, 72758, United States\|Advanced Skincare Surgery & Medcenter, Burbank, California, 91505, United States\|University of South Florida, Tampa, Florida, 33612, United States\|Shideler Clinical Research Center, Carmel, Indiana, 46032, United States\|Dawes Fretzin Clinical Research Group, Indianapolis, Indiana, 46256, United States\|Montefiore Medical Center, New York, New York, 10467, United States\|Arlington Research Center for Dermatology, Arlington, Texas, 76011, United States\|UZ Gent Dermatology Department, Gent, 9000, Belgium\|Lynderm Research Inc., Markham, Ontario, L3P1X2, Canada\|CHU Sainte-Justine, Montreal, Quebec, H3T1C5, Canada\|Charité Universit?tsmedizin Berlin, Berlin, 10117, Germany\|University Hospital Carl Gustav Carus, Dresden, 01307, Germany\|Universit?ts-Hautklinik Mainz, Johannes Gutenberg-Universit?t Mainz, Mainz, 55131, Germany\|Padova University Hospital, Padova, 35128, Italy\|University of Parma, Parma, 43126, Italy Less <<
NCT00862693	Glomerulonephritis\|Autoimmune ... More >>Diseases Less <<	PHASE4	UNKNOWN	2025-03-11	Renal Division, Peking Univers... More >>ity First Hospital, Beijing, Beijing, 100034, China Less <<
NCT03216564	Diabetic Nephropathies	PHASE3	UNKNOWN	2019-05-10	Hamad Medical Corporation, Doh... More >>a, Qatar Less <<
NCT03820518	X-linked Hypophosphatemia	PHASE4	UNKNOWN	2022-12-31	Department of Endocrinology, P... More >>eking Union Medical College Hospital, Beijing, Beijing, 100730, China Less <<
NCT01293682	Breast Cancer	PHASE2	COMPLETED	2025-12-21	University of Rochester, Roche... More >>ster, New York, 14642, United States Less <<
NCT05415254	COVID-19\|Vitamin D Deficiency		UNKNOWN	2022-09-19	Renji Hospital, Shanghai, Shan... More >>ghai, 200127, China Less <<
NCT00601328	Secondary Hyperparathyroidism\|... More >>Hypocalcemia Less <<		COMPLETED	2025-08-03	Bio-Kinetic Clinical Applicati... More >>ons, Inc., Springfield, Missouri, 65801, United States Less <<
NCT01039181	Advanced Intrahepatic Cholangi... More >>ocarcinoma Less <<	PHASE2	UNKNOWN	2025-10-12	Srinagarind Hospital, Faculty ... More >>of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand Less <<
NCT01820832	Chronic Kidney Disease\|Protein... More >>uria Less <<	PHASE4	UNKNOWN	2025-06-15	Huashan Hospital, Fudan Univer... More >>sity, Shanghai, Shanghai, 200040, China Less <<

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.40mL 0.48mL 0.24mL	12.00mL 2.40mL 1.20mL	24.00mL 4.80mL 2.40mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed