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Chemical Structure| 33286-30-5 Chemical Structure| 33286-30-5

Structure of 33286-30-5

Chemical Structure| 33286-30-5

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Gummiferin can act as an inhibitor of the adenine-nucleotide translocation.

Synonyms: Gummiferin; Gummiferin dipotassium

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Product Details of Carboxyatractyloside dipotassium

CAS No. :33286-30-5
Formula : C31H46K2O18S2
M.W : 849.01
SMILES Code : C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C(O)=O)(C[C@H](C2)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)OS(=O)(O)=O)OS(=O)(O)=O)OC(CC(C)C)=O)C(O)=O)C[C@H](C([C@@H]4O)=C)CC3.[K].[K]
Synonyms :
Gummiferin; Gummiferin dipotassium
MDL No. :MFCD00152201

Safety of Carboxyatractyloside dipotassium

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Sunflower seed mitochondria 100 μM Inhibited ATP synthesis Plant Physiol. 1991 Feb;95(2):390-8
C2C12 myotubes 0.5 μM Inhibit ANT1 activity, reduce sensitivity to FA-induced uncoupling Diabetologia. 2016 May;59(5):1030-9
brain mitochondria 2 μM 1 hour Inhibits ANT, preventing FA-induced increase in respiratory rate Antioxidants (Basel). 2022 Jan 20;11(2):198
Trypanosoma brucei mitochondria 5 μg/μl 10 min To assess the location of mitochondrial tRNA, results showed that CAT inhibited the labeling of mitochondrial tRNA, indicating that the tRNA is located within the mitochondrial matrix. EMBO J. 1995 Sep 1;14(17):4212-20

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Rats Hepatic ischemia/reperfusion injury model Intraperitoneal injection 5 mg/kg Single dose, lasting until 6 hours of reperfusion Increase MPTP susceptibility, partially reverse the protective effect of EP4 agonist CAY10598 Int J Mol Med. 2020 Jun;45(6):1825-1837

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.18mL

0.24mL

0.12mL

5.89mL

1.18mL

0.59mL

11.78mL

2.36mL

1.18mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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