CAS No. :	3650-09-7
Formula :	C₂₀H₂₈O₄
M.W :	332.43
SMILES Code :	O=C([C@]12CCCC(C)(C)[C@]1([H])CCC3=C2C(O)=C(O)C(C(C)C)=C3)O
Synonyms :	Salvin
MDL No. :	MFCD02259459
InChI Key :	QRYRORQUOLYVBU-VBKZILBWSA-N
Pubchem ID :	65126

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

HepG2 cells	10 µM	1 hour	Induced phosphorylation of AMPK and ACC	Int J Mol Sci. 2021 Apr 14;22(8):4040.
H1299 cells	50 µM	1.5-24 hours	Induced autophagy, increased LC3-II levels	Int J Mol Sci. 2024 Feb 6;25(4):1950.
HEK-293T cells	10 µM	1 hour	Induced phosphorylation of AMPK and ACC	Int J Mol Sci. 2021 Apr 14;22(8):4040.
MRSA (Methicillin-resistant Staphylococcus aureus)	0.05 mg/mL	16 hours	To evaluate the interference of carnosic acid with the quorum sensing system of MRSA, results showed that carnosic acid significantly reduced the expression of agrA and rnaIII genes.	Plants (Basel). 2023 Oct 25;12(21):3679.
SH-SY5Y cells	0.5, 1, or 3 µM	18 hours	To investigate the protective effect of carnosic acid on L-dopa-induced cytotoxicity. Results showed that pretreatment with CA attenuated the cell death and nuclear condensation induced by L-dopa.	Front Pharmacol. 2021 Aug 9;12:703894.
3T3-L1 pre-adipocytes	10–20 µM	2 days	Carnosic acid significantly attenuated the early increase in both superoxide anion and ROS levels induced by the MDI hormone mixture, thereby inhibiting adipocyte differentiation.	Int J Mol Sci. 2021 Jun 5;22(11):6096.
HepG2 cells	10 µM	24 hours	Inhibited the expressions of gluconeogenic genes G6PC and PCK1	Int J Mol Sci. 2021 Apr 14;22(8):4040.
Caco-2	2.60 μg/mL	24 hours	Evaluate the antitumor activity of CA-BSA-NPs on Caco-2 cells, showing significant reduction in cell viability and induction of G2/M phase cell cycle arrest.	Molecules. 2022 Jun 25;27(13):4102.
MCF-7	6.02 μg/mL	24 hours	Evaluate the antitumor activity of CA-BSA-NPs on MCF-7 cells, showing significant reduction in cell viability and induction of G2/M phase cell cycle arrest.	Molecules. 2022 Jun 25;27(13):4102.
Human neuroblastoma SH-SY5Y cells	0.1-10 µM	24 hours	In NB medium, CA (1-5 µM) notably protected both undifferentiated and RA-differentiated SH-SY5Y cells from H2O2 damage, with efficacy comparable to or exceeding NAC.	Molecules. 2023 Dec 24;29(1):119.
Mouse primary neuronal cell cultures	0.1-10 µM	24 hours	CA at 0.5-10 µM significantly increased cell viability (28–52%) and reduced LDH release (~40%), demonstrating protection against H2O2-induced oxidative damage.	Molecules. 2023 Dec 24;29(1):119.
INS-1 (832/13) cells	2.5, 5, 10 µM	24 hours	Evaluate the effect of CA on INS-1 cell viability, results showed no cytotoxicity at tested concentrations	Molecules. 2022 Mar 24;27(7):2102.
HT-29 cells	20 μg/mL	24-hours pretreatment followed by 16-hours co-incubation	To evaluate the protective effect of rosemary extract against tBHP-induced ZO-1 protein loss, results showed that rosemary extract pretreatment rescued 67% of ZO-1 fluorescence intensity lost to tBHP treatment	Nutrients. 2021 Feb 27;13(3):773.
N2a22L cells	13.58 µM	48 hours	To evaluate the antioxidant and anti-prion effects of CA, results showed that CA significantly reduced ROS production and decreased PrPSc accumulation.	Antioxidants (Basel). 2022 Apr 6;11(4):726.
A549 (lung adenocarcinoma cells)	0.05 mg/mL	48 hours	To assess the cytotoxicity of carnosic acid on eukaryotic cells, results showed no cytotoxic effects within 48 hours.	Plants (Basel). 2023 Oct 25;12(21):3679.
THP-1 (macrophage-like cells)	0.05 mg/mL	48 hours	To assess the cytotoxicity of carnosic acid on eukaryotic cells, results showed no cytotoxic effects within 48 hours.	Plants (Basel). 2023 Oct 25;12(21):3679.

C57BL/6 mice	DSS-induced colitis model	Oral gavage	100 mg/kg	Once daily for 10 days	To assess the preventive effect of rosemary extract on DSS-induced colitis, results showed that 100 mg/kg rosemary extract significantly improved DAI scores, reduced colon bleeding, and improved intestinal barrier integrity	Nutrients. 2021 Feb 27;13(3):773.
Wistar rats	6-hydroxydopamine (6-OHDA) lesion model	Oral intubation	3 or 15 mg/kg	Once daily for 4 days	To investigate the effect of carnosic acid on L-dopa-induced dyskinesia. Results showed that pretreatment with CA significantly reduced L-dopa-induced abnormal involuntary movements (AIMs) and ALO scores.	Front Pharmacol. 2021 Aug 9;12:703894.
C57BL/6 mice	LPS-induced acute kidney injury model	Intraperitoneal injection	40 mg/kg	Single injection, sacrificed after 24 hours	To evaluate the therapeutic effect of Carnosic acid on LPS-induced acute kidney injury, results showed that Carnosic acid improved kidney injury and renal function.	Molecules. 2021 Dec 14;26(24):7589

NCT03769376	Partial Edentulism	Not Applicable	Not yet recruiting	January 2020	United States, Colorado ... More >> University of Colorado School of Dental Medicine Not yet recruiting Aurora, Colorado, United States, 80045 Contact: Kerri Font, DDS, MS Less <<
NCT03130933	Postoperative Complications ... More >> Third Molar Less <<	Phase 1 Phase 2	Completed	-	Croatia ... More >> School of dental medicine, University of Zagreb Zagreb, Croatia, 10000 Less <<

{[proInfo.proName]}

CAS No.: 3650-09-7

{[proInfo.proName]}

CAS No.: 3650-09-7

Alternative Products

Product Details of Carnosic acid

Safety of Carnosic acid

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed