CC-115 | DNA-PK/mTOR Inhibitor

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CAS No. :	1228013-15-7
Formula :	C₁₆H₁₆N₈O
M.W :	336.35
SMILES Code :	O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2
MDL No. :	MFCD29036965
InChI Key :	GMYLVKUGJMYTFB-UHFFFAOYSA-N
Pubchem ID :	58298318

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Multiple myeloma cells	1.5 nM to 10 µM	72 h	CC-115 showed dose-dependent growth inhibition in multiple myeloma cells, and its effect was superior to the specific TORK inhibitor CC-223.	PMC9892823
HCT 116 cells	0.1 µM to 3.5 µM	4 h	CC-115 induced a dose-dependent increase in NMD transcripts in HCT 116 cells, indicating inhibition of SMG1-mediated NMD.	PMC9892823
CAL33	1 µM	24 h	CC-115 + IR treatment led to an elevation in G2/M arrest, increased cell death, and a synergistic reduction in cell proliferation, though the effect was notably lower compared to the AZD7648 + IR- treated group.	PMC10887161
UM-SCC-47	1 µM	24 h	CC-115 + IR treatment led to an elevation in G2/M arrest, increased cell death, and a synergistic reduction in cell proliferation, though the effect was notably lower compared to the AZD7648 + IR- treated group.	PMC10887161
LNCaP-AR	1 μM	24 h	reduced invasion and migration of CRPC cells	PMC6744969
C4-2B	1 μM	24 h	reduced invasion and migration of CRPC cells	PMC6744969
LNCaP-AR-enza-res	1 μM	24 h	reduced invasion and migration of enzalutamide-resistant CRPC cells	PMC6744969
C4-2	0–25 μM	6 days	Assessment of CC-115 in hormone-sensitive and castration-resistant prostate cancer models showed that CC-115 reduced cell viability in a dose-dependent manner and induced apoptosis.	PMC6744985
22Rv1	0–25 μM	6 days	Assessment of CC-115 in hormone-sensitive and castration-resistant prostate cancer models showed that CC-115 reduced cell viability in a dose-dependent manner and induced apoptosis.	PMC6744985
Healthy donor skin fibroblasts (SBLF7)	0.1–25 μM	48 h	To study the effect of CC-115 on cell death, results showed that cell death increased linearly with increasing concentration of CC-115.	PMC7730287
Melanoma cells (ARPA)	0.1–25 μM	48 h	To study the effect of CC-115 on cell death, results showed that melanoma cells were more sensitive to CC-115, with cell death reaching saturation at higher concentrations.	PMC7730287
Melanoma cells (HV18MK)	0.1–25 μM	48 h	To study the effect of CC-115 on cell death, results showed that melanoma cells were more sensitive to CC-115, with cell death reaching saturation at higher concentrations.	PMC7730287
LOU-NH91	25.10 μM	72 h	Assessed the IC50 value of CC-115 on LOU-NH91 cells, showing synergistic effects with carboplatin	PMC9452486
H596	0.68 μM	72 h	Assessed the IC50 value of CC-115 on H596 cells, showing synergistic effects with carboplatin	PMC9452486
H1975	0.31 μM	72 h	Assessed the IC50 value of CC-115 on H1975 cells, showing synergistic effects with carboplatin	PMC9452486
TM00244	0.43 μM	72 h	Assessed the IC50 value of CC-115 on TM00244 cells, showing synergistic effects with carboplatin	PMC9452486
H226	0.95 μM	72 h	Assessed the IC50 value of CC-115 on H226 cells, showing synergistic effects with carboplatin	PMC9452486
Calu-1	1.38 μM	72 h	Assessed the IC50 value of CC-115 on Calu-1 cells, showing synergistic effects with carboplatin	PMC9452486
Atmfl/fl; LSL-KrasG12D/+; Ptf1aCre/+ (AKC) cells	30 nM	6 h	To evaluate the effect of CC-115 on DNA replication dynamics	PMC7948173
ATM+/Δ MIA PaCa-2 cells	30 nM	48 h	To evaluate the synergistic effect of CC-115 in combination with PARPi and ATRi	PMC7948173
LOU-NH91	0.2 μM	72 h	CC-115 in combination with carboplatin showed synergistic effects in LOU-NH91 cells, significantly inhibiting cell viability.	PMC9452486
Calu-1	0.4 μM	72 h	CC-115 in combination with carboplatin showed synergistic effects in Calu-1 cells, significantly inhibiting cell viability.	PMC9452486
H226	0.4 μM	72 h	CC-115 in combination with carboplatin showed synergistic effects in H226 cells, significantly inhibiting cell viability.	PMC9452486

Mice	Multiple myeloma xenograft model	Oral	5 mg/kg	Once daily until day 36	CC-115 showed significant antitumor activity in the multiple myeloma xenograft model, with a significant reduction in tumor volume and good tolerability.	PMC9892823
CB17-SCID mice	LNCaP-AR xenograft model	oral	2 mg/kg	5 times per week for 6 weeks	significantly delayed tumor growth	PMC6744969
CB17 SCID mice	Castration-resistant prostate cancer model	Oral	2 mg/kg	Once daily for 39 days	Evaluation of the tumor growth inhibitory effects of CC-115 in combination with Enzalutamide in castration-resistant prostate cancer models showed that the combination treatment significantly increased tumor doubling time and improved survival rates.	PMC6744985
mice	LUSC PDX models	oral gavage and I.P. injection	1 mg/kg	once weekly for four weeks	Evaluated the antitumor effect of CC-115 in combination with carboplatin and paclitaxel on LUSC PDX models, showing significant tumor growth inhibition and prolonged survival	PMC9452486
Mice	Subcutaneous tumor model	Intraperitoneal injection	2.5 mg/kg	Once daily for 17 days	To evaluate the inhibitory effect of CC-115 in combination with PARPi and ATRi on the growth of ATM-deficient PDAC tumors	PMC7948173
Mice	LUSC patient-derived xenograft models	Oral gavage (CC-115), Intraperitoneal injection (carboplatin and paclitaxel)	1 mg/kg	Once weekly (carboplatin and paclitaxel), daily (CC-115), for four weeks	CC-115 in combination with carboplatin and paclitaxel significantly inhibited tumor growth and extended survival in mice.	PMC9452486

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CAS No.: 1228013-15-7

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CAS No.: 1228013-15-7

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed