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Chemical Structure| 1922098-69-8 Chemical Structure| 1922098-69-8

Structure of CCG-222740
CAS No.: 1922098-69-8

Chemical Structure| 1922098-69-8

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CCG-222740 is a Rho/MRTF pathway inhibitor. It decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin (α-SMA) expression. It also modulates inflammatory components of the pancreas in KC mice (LSL-KrasG12D/+; Pdx-1-Cre) stimulated with caerulein.

Synonyms: CCG-222740

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Product Details of CCG-222740

CAS No. :1922098-69-8
Formula : C23H19ClF2N2O3
M.W : 444.86
SMILES Code : O=C(C1CN(C(C2=CC=CC(C3=CC=CO3)=C2)=O)CC(F)(F)C1)NC4=CC=C(Cl)C=C4
Synonyms :
CCG-222740
MDL No. :MFCD32215314
InChI Key :PMTPYUTZAJWGPE-UHFFFAOYSA-N
Pubchem ID :121317937

Safety of CCG-222740

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Related Pathways of CCG-222740

GPCR
cytoskeleton

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HEK-293T cells 30 μM Used in affinity pulldown experiments to identify pirin as a potential target via mass spectrometry PMC7006939

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.24mL

2.25mL

1.12mL

22.48mL

4.50mL

2.25mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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