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Chemical Structure| 2453324-32-6 Chemical Structure| 2453324-32-6

Structure of CCT128930 HCl
CAS No.: 2453324-32-6

Chemical Structure| 2453324-32-6

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CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.

Synonyms: CCT128930 hydrochloride

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Product Details of CCT128930 HCl

CAS No. :2453324-32-6
Formula : C18H21Cl2N5
M.W : 378.30
SMILES Code : NC1(CC2=CC=C(Cl)C=C2)CCN(C3=C4C(NC=C4)=NC=N3)CC1.[H]Cl
Synonyms :
CCT128930 hydrochloride
MDL No. :MFCD32667039
InChI Key :OFLOSUNRPFWODP-UHFFFAOYSA-N
Pubchem ID :146013807

Safety of CCT128930 HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of CCT128930 HCl

PI3K-AKT

Isoform Comparison

Biological Activity

Description
CCT128930 hydrochloride is a potent and selective AKT inhibitor, with an IC50 of 6 nM. It exhibits 28-fold selectivity against the closely related PKA kinase, with an IC50 of 168 nM, and 20-fold selectivity over p70S6K, with an IC50 of 120 nM. This selectivity is achieved through targeting Met282 of AKT (Met173 of PKA-AKT chimera). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy, demonstrating significant antitumor activity[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.22mL

2.64mL

1.32mL

26.43mL

5.29mL

2.64mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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