Structure of Cetuximab
CAS No.: 205923-56-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Cetuximab is a chimeric IgG1 monoclonal antibody that prevents the binding of ligands to the EGFR extracellular domain by binding to it. Cetuximab has potential for research in squamous cell carcinoma of the head and neck and colorectal cancer.
Synonyms: C225
4.5
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CAS No. : | 205923-56-4 |
M.W : | 145.56 kDa |
SMILES Code : | NONE |
Synonyms : |
C225
|
MDL No. : | MFCD06407972 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
NK cells | 10 μg/mL | 24 hours | To evaluate the killing effect of NK cells on HNSCC cells in the presence of Lirilumab, results showed that Lirilumab significantly enhanced NK cell-mediated killing of tumor cells. | Head Neck. 2019 Aug;41(8):2591-2601 |
IL-1R1 stable knockdown SQ20B cells | 1, 10, and 100 μg/mL | 48 h | IL-1R1 knockdown significantly suppressed cetuximab-induced cytokine secretion. | J Immunother Cancer. 2019 Mar 19;7(1):79 |
MyD88 stable knockdown SQ20B cells | 1, 10, and 100 μg/mL | 48 h | MyD88 knockdown significantly suppressed cetuximab-induced cytokine secretion. | J Immunother Cancer. 2019 Mar 19;7(1):79 |
SQ20B cells | 1, 10, and 100 μg/mL | 48 h | Cetuximab at a dose of 100 μg/mL significantly increased IL-1α and IL-8 secretion, and increased IL-6 secretion at all tested concentrations. | J Immunother Cancer. 2019 Mar 19;7(1):79 |
Cal-27 cells | 1, 10, and 100 μg/mL | 48 h | Cetuximab at a dose of 100 μg/mL significantly increased IL-1α, IL-6, and IL-8 secretion. | J Immunother Cancer. 2019 Mar 19;7(1):79 |
DLD-1 | 100 μg/ml | 24 h | To evaluate the cytotoxic and antiproliferative effects of Cetuximab combined with RSL3 on KRAS mutant CRC cells. Results showed that the combination treatment significantly inhibited cell viability and proliferation. | Cell Death Dis. 2021 Nov 13;12(11):1079 |
HCT116 | 100 μg/ml | 24 h | To evaluate the cytotoxic and antiproliferative effects of Cetuximab combined with RSL3 on KRAS mutant CRC cells. Results showed that the combination treatment significantly inhibited cell viability and proliferation. | Cell Death Dis. 2021 Nov 13;12(11):1079 |
C10 | 1 ng/µL | 72 h | To assess the efficacy of targeting the AURKA/YAP1 axis to overcome cetuximab resistance | Br J Cancer. 2024 May;130(8):1402-1413 |
SW48 | 10 ng/µL | 72 h | To assess the efficacy of targeting the AURKA/YAP1 axis to overcome cetuximab resistance | Br J Cancer. 2024 May;130(8):1402-1413 |
HCT116 cells | 0.1 μM or 1 μM | 24 h | To evaluate the effect of Cetuximab on EGFR protein expression. Results showed that Cetuximab only marginally affected EGFR levels in HCT116 cells. | J Nucl Med. 2018 Oct;59(10):1558-1565 |
H1975 cells | 0.1 μM or 1 μM | 24 h | To evaluate the effect of Cetuximab on EGFR protein expression. Results showed that 0.1 μM Cetuximab reduced EGFR protein expression by 3-fold in H1975 cells, while the effect was slightly attenuated at the higher dose (1 μM). | J Nucl Med. 2018 Oct;59(10):1558-1565 |
UMSCC 103 | 20 μM | 48 h | Test the cytotoxic effect of Cetuximab on UMSCC 103, finding significant cell death when combined with ICI | Cell Death Dis. 2023 Sep 19;14(9):613 |
Patient-derived colorectal cancer organoids (PDXO) | 20 μg/mL | 72 h | To evaluate the effect of cetuximab on BIM protein expression, results showed that cetuximab upregulated BIM protein levels. | Clin Cancer Res. 2023 Mar 14;29(6):1102-1113 |
Patient-derived colorectal cancer organoids (PDXO) | 20 μg/mL | 1 week | To evaluate the effect of cetuximab on PDXO cell viability, results showed that cetuximab inhibited cell growth. | Clin Cancer Res. 2023 Mar 14;29(6):1102-1113 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Athymic nu/nu mice | Cal-27 and SQ20B xenograft models | Intraperitoneal injection | 2 mg/kg | Twice weekly for 2 weeks | IL-1 blockade (using anakinra) did not affect the anti-tumor efficacy of cetuximab. | J Immunother Cancer. 2019 Mar 19;7(1):79 |
BALB/c nude mice | DLD-1 xenograft model | Intraperitoneal injection | 13 mg/kg | Once daily for 17 days | To evaluate the antitumor effects of Cetuximab combined with RSL3 on KRAS mutant CRC xenograft models. Results showed that the combination treatment significantly reduced tumor volume and increased MDA levels. | Cell Death Dis. 2021 Nov 13;12(11):1079 |
Mice | Patient-derived xenograft (PDX) models of KRAS-mutated colorectal cancer | Intraperitoneal injection | 25 mg/kg | Twice weekly, for 28 days or longer | To evaluate the efficacy of combined Cetuximab and Trametinib therapy in KRAS-mutated CRC PDX models. The combination therapy induced disease control (partial response or stable disease) in 74% of the models analyzed, with 47% achieving partial response. | Mol Oncol. 2023 Nov;17(11):2396-2414 |
Nude mice | Orthotopic HNSCC mouse model | Intraperitoneal injection | 40 mg/kg | Every 3 days for 4 weeks | Evaluate the effect of Cetuximab alone or in combination with ICI on HNSCC tumor growth, finding significant tumor growth delay with combination therapy | Cell Death Dis. 2023 Sep 19;14(9):613 |
BALB/c nude mice | H1975 tumor model (non-small cell lung cancer) and HCT116 tumor model (colorectal cancer) | Intravenous injection (Cetuximab) or intraperitoneal injection (Gemcitabine) | 10 mg/kg | Cetuximab was administered on day 1 or days 1 and 2, Gemcitabine on day 2, and imaging was performed on day 3. | To evaluate the effect of Cetuximab alone or in combination with Gemcitabine on tumor growth and biological markers. Results showed that repeated doses of Cetuximab significantly increased 18F-ICMT-11 uptake and cleaved caspase-3 staining in H1975 tumors, while a single dose was insufficient to induce apoptosis but affected proliferation. 18F-FLT uptake was significantly reduced, paralleled by a decrease in Ki-67 and marked tumor growth delay. HCT116 tumors were insensitive to Cetuximab treatment. | J Nucl Med. 2018 Oct;59(10):1558-1565 |
NSG mice | CDX-humanized mouse model | Intravenous injection | 0.4 mg/kg/dose | Weekly for 5 weeks | Evaluate the antitumor effects of cetuximab in combination with NK cells | J Immunother Cancer. 2024 Mar 27;12(3):e008585 |
NOD/SCID mice | Patient-derived xenograft models (PDX) | Intraperitoneal injection | 20 mg/kg | Twice weekly for 5 weeks | To evaluate the effect of cetuximab on tumor volume in PDX models, results showed that cetuximab significantly reduced tumor volume. | Clin Cancer Res. 2023 Mar 14;29(6):1102-1113 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03524820 | Cancer of Colon | PHASE2 | TERMINATED | 2021-12-31 | Hadassah Ein Kerem, Jerusalem,... More >> 91120, Israel Less << |
NCT00698841 | Advanced Cancer | PHASE2 | COMPLETED | 2025-02-10 | Northwest Alabama Cancer Cente... More >>r, Muscle Shoals, Alabama, 35661, United States|Donald W. Hill, MD, Casa Grande, Arizona, 85222, United States|Compassionate Cancer Care Medical Group, Inc, Corona, California, 92879, United States|Compassionate Cancer Care Medical Group Inc, Fountain Valley, California, 92708, United States|Pacific Shores Medical Group, Long Beach, California, 90813, United States|Desert Hospital Comprehensive Cancer Center, Palm Springs, California, 92262, United States|Compassionate Cancer Care Medical Group, Inc, Riverside, California, 92501, United States|American Institute Research, Whittier, California, 90603, United States|Georgetown University Medical Center, Washington, District of Columbia, 20007, United States|Baptist Cancer Institute, Jacksonville, Florida, 32207, United States|Ocala Oncology Center, Ocala, Florida, 34471, United States|Brinz, Burroff, Gurtler, & Russo, Metairie, Louisiana, 70006, United States|Cancer Specialists Of Oklahoma, Oklahoma City, Oklahoma, 73112, United States|Pharma Resource, East Providence, Rhode Island, 02915, United States|Austin Cancer Centers, Austin, Texas, 78759, United States|Local Institution, San Juan, 00910, Puerto Rico Less << |
NCT00251381 | Oropharyngeal Neoplasms | PHASE2 | UNKNOWN | 2025-11-09 | Hospital Germans Tries i Pujol... More >>, Badalona, Barcelona, 08196, Spain|Institut Catala Oncologia: Hospital Duran y Reynals, Hospitalet de Llobregat, Barcelona, 08097, Spain|Centro Oncológico Regional de Galicia, A Coruna, Coru?a, 15009, Spain|H.U. Virgen de la Arrixaca, El Palmar, Murcia, 30120, Spain|Hospital de Navarra, Pamplona, Navarra, 31008, Spain|H. U. de Canarias, Santa Cruz de Tenerife, Sta Cruz de Tenerife, 38320, Spain|H. del Mar / H. de la Esperanza, Barcelona, 08003, Spain|H. de la Santa Creu I Sant Pau, Barcelona, 08025, Spain|H. Josep Trueta (ICO), Girona, 17007, Spain|H. G. Doctor Negrín, Las Palmas de Gran Canaria, 35020, Spain|Clinica Ruber Internacional, Madrid, 28034, Spain|H. Ramón y Cajal, Madrid, 28034, Spain|Fundación Jiménez Díaz, Madrid, 28040, Spain|H. Gregorio Mara?ón, Madrid, 28040, Spain|Complejo Hospitalario Virgen de la Victoria, Malaga, 29010, Spain|H. Carlos Haya, Malaga, 29010, Spain|H.U. de Santiago, Santiago, 15706, Spain|H. do Meixoeiro, Vigo, 36200, Spain Less << |
NCT01192087 | Adenoid Cystic Carcinoma | PHASE1|PHASE2 | UNKNOWN | 2025-07-17 | Dept. of Radiation Oncology, H... More >>eidelberg, 69120, Germany Less << |
NCT01382407 | Colorectal Cancer Metastatic | COMPLETED | 2017-04-01 | Oncology Institute, Rambam Hea... More >>lth Care Campus, Haifa, 31096, Israel|Rambam Health Care Campus, Haifa, 31096, Israel Less << | |
NCT03769311 | Head and Neck Cancer|Squamous ... More >>Cell Carcinoma Less << | PHASE2 | COMPLETED | 2022-03-15 | University of Wisconsin Carbon... More >>e Cancer Center, Madison, Wisconsin, 53792, United States Less << |
NCT00362102 | Colorectal Carcinoma | PHASE2 | COMPLETED | 2025-07-06 | - |
NCT01051167 | Metastatic Colorectal Cancer | PHASE2 | COMPLETED | 2025-09-16 | University of Duisburg-Essen M... More >>edical School, Essen, Nordrhein-Westfalen, 45122, Germany|Alfried Krupp von Bohlen und Halbach Krankenhaus gGmbH, Essen, Nordrhein-Westfalen, 45131, Germany|Prosper Hospital Recklinghausen, Recklinghausen, Nordrhein-Westfalen, 45659, Germany Less << |
NCT00791141 | Head and Neck Cancer | PHASE2 | COMPLETED | 2025-09-13 | Department of Radiotherapy and... More >> Radiological Oncology, University Hospital Munich, Munich, Bavaria, 81377, Germany|Department of Radiotherapeutics of the University Hospital Freiburg, Freiburg, BW, 79106, Germany|Department of Radiological Oncology University Hospital Heidelberg, Heidelberg, BW, 69120, Germany|Department of Radiotherapy and Radiological Oncology University Hospital Tuebingen, Tuebingen, BW, 72076, Germany|Department of Radiotherapy and Radiological Oncology University Hospital Ulm, Ulm, BW, 89091, Germany|Department of Radiotherapy an Radiological Oncology University Hospital Essen, Essen, NW, 45122, Germany|Department of Radiotherapy and Radiological Oncology University Hospital Mainz, Mainz, Rheinland-Pfalz, 55131, Germany|Department of Radiotherapy, University Hospital Schleswig Holstein, Campus Lübeck, Lübeck, Schleswig Hostein, 23538, Germany|Department of Radiotherapy and Radiological Oncology Universit?t Hospital Jena, Jena, Thueringen, 07743, Germany|Charité University Medicine, Department of Radiotherapy and Radiological Oncology, Berlin, 13353, Germany Less << |
NCT00694603 | Non-small Cell Lung Cancer | PHASE2 | TERMINATED | 2025-09-09 | Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less << |
NCT00251498 | Carcinoma, Non-Small-Cell Lung | PHASE2 | COMPLETED | 2025-10-07 | Veeda Oncology, Houston, Texas... More >>, 77042, United States Less << |
NCT00392769 | Endometrial Cancer | PHASE2 | COMPLETED | 2025-12-10 | New York Presbyterian Hospital... More >>-Cornell Medical Center, New York, New York, 10021, United States|UT MD . Anderson Cancer Center, Houston, Texas, 77030, United States Less << |
NCT05873972 | Colorectal Cancer Liver Metast... More >>ases Less << | UNKNOWN | 2024-12-31 | Zhongshan Hospital, Fudan Univ... More >>ersity, Shanghai, Shanghai, 200032, China|Zhongshan hosptial, Fudan University, Shanghai, 200032, China Less << | |
NCT00207155 | Metastatic Colorectal Cancer | PHASE1 | COMPLETED | 2025-02-06 | Local Institution, Duarte, Cal... More >>ifornia, United States|Local Institution, Tampa, Florida, United States|Local Institution, Baltimore, Maryland, United States|Local Institution, St. Louis, Missouri, United States|Local Institution, New Brunswick, New Jersey, United States|Local Institution, Bronx, New York, United States|Local Institution, Cincinnati, Ohio, United States|Local Institution, Cleveland, Ohio, United States|Local Institution, Hershey, Pennsylvania, United States|Local Institution, Philadelphia, Pennsylvania, United States|Local Institution, Nashville, Tennessee, United States|Local Institution, San Antonio, Texas, United States|Local Institution, Montreal, Quebec, Canada|Local Institution, Barcelona, Spain Less << |
NCT01075828 | Head and Neck Cancer | COMPLETED | 2025-07-14 | Chungnam National University H... More >>ospital, Jung-gu Daejeon, 301-721, Korea, Republic of Less << | |
NCT01142869 | Carcinoma, Squamous Cell | TERMINATED | 2014-08-05 | Ambaa Hospitals, Hyderabad, An... More >>dhra Pradesh, 500008, India|Indo- American Cancer Institute & Research Centre, Hyderabad, Andhra Pradesh, 500034, India|NVS Ramakrishna's Clinic, Hyderabad, Andhra Pradesh, 500063, India|Dr. Nikhil's Clinic, Secunderabad, Andhra Pradesh, 500025, India|Swarna Sai Hospital, Secunderabad, Andhra Pradesh, 500059, India|Sparsh Hospital, Orissa, Bhubaneswar, 751007, India|All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India|Wellness Consultants Clinic, Surat, Gujarat, 395002, India|Global Health Pvt Ltd, Gurgaon, Haryana, 122001, India|The Cancer Clinic, Kochin, Kerala, 682304, India|Dr. T. P. Sahoo's Clinic, Bhopal, Madhya Pradesh, 462001, India|BND Onco Centre, Mumbai, Maharashtra, 400014, India|S.L.Raheja Hospital, Mumbai, Maharashtra, 400016, India|S M Karandikar's Clinic, Pune, Maharashtra, 400014, India|Ruby Hall Clinic, Pune, Maharashtra, 411001, India|Galaxy Care Laproscopic Institute, Pune, Maharashtra, 411004, India|Neigrihms, Shillong, Meghalaya, 793005, India|Grace Nursing Home, Aizwal, Mizoram, 796 009, India|Cancer Clinic, Jaipur, Rajasthan, 302004, India|SMS Hospital, Jaipur, Rajasthan, 302004, India|Bhagwan Mahaveer Cancer Hospital, Jaipur, Rajasthan, 302006, India|J.K.Cancer Institute, Kanpur, Uttar Pradesh, 208002, India|Annapurna Medical and Cancer Relief Society, Lucknow, Uttar Pradesh, 226007, India|Dr. Vineet's Clinic, New Delhi, Uttar Pradesh, 110085, India|SMH-Curie Cancer Centre, Shanti Mukand Hospital, New Delhi, Uttar Pradesh, 110092, India|Apollo Gleneagles Cancer Hospital, Kolkata, West Bengal, 700054, India|B.R. Singh Hospital, Kolkatta, West Bengal, 700014, India|Sunil Gupta's Clinic, Delhi, 110092, India Less << | |
NCT00492206 | Non Small Cell Lung Cancer (NS... More >>CLC) Less << | PHASE2 | COMPLETED | 2025-02-12 | Sylvester Comprehensive Cancer... More >> Center, University of Miami, Miami, Florida, 33136, United States|Emory Winship Cancer Institute, Atlanta, Georgia, 30322, United States|Sidney Kimmel Comprehensive Cancer Center at John Hopkins, Baltimore, Maryland, 21231, United States|UPMC Cancer Center -Teramana Cancer Center, Steubenville, Ohio, 43952, United States|UPMC Cancer Center -Beaver, Beaver, Pennsylvania, 15009, United States|UPMC Cancer Center - Clairton, Clairton, Pennsylvania, 15025, United States|UPMC Cancer Center - Oakbrook Commons, Greensburg, Pennsylvania, 15601, United States|UPMC Cancer Center -Arnold Palmer Pavilion, Greensburg, Pennsylvania, 15601, United States|Penn State Cancer Institute, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, 17033, United States|UPMC Cancer Center -Indiana, Indiana, Pennsylvania, 15701, United States|UPMC Cancer Center -John P. Murtha Pavilion, Johnstown, Pennsylvania, 15901, United States|UPMC Cancer Center -McKeesport, McKeesport, Pennsylvania, 15132, United States|UPMC Cancer Center -Haymaker Rd., Monroeville, Pennsylvania, 15146, United States|UPMC Cancer Center -Mosside Blvd., Monroeville, Pennsylvania, 15146, United States|UPMC Cancer Center -Sewickley Medical Center, Moon Township, Pennsylvania, 15108, United States|UPMC Cancer Center -Mt. Pleasant, Mt. Pleasant, Pennsylvania, 15666, United States|UPMC Cancer Center -Jameson, New Castle, Pennsylvania, 16105, United States|UPMC Cancer Center -New Castle, New Castle, Pennsylvania, 16105, United States|UPMC Presbyterian -Radiation Oncology, Pittsburgh, Pennsylvania, 15213, United States|UPMC Cancer Center -Delafield Rd., Pittsburgh, Pennsylvania, 15215, United States|UPMC Cancer Center -St. Margaret, Pittsburgh, Pennsylvania, 15215, United States|Universtity of Pittsburgh Cancer Institute -Hillman Cancer Center, Pittsburgh, Pennsylvania, 15232, United States|UPMC Cancer Center -UPMC Shadyside, Pittsburgh, Pennsylvania, 15232, United States|UPMC Cancer Center -Passavant, Pittsburgh, Pennsylvania, 15237, United States|UPMC Cancer Center -Drake, Pittsburgh, Pennsylvania, 15241, United States|UPMC Cancer Center -St. Clair, Pittsburgh, Pennsylvania, 15243, United States|UPMC Cancer Center -UPMC Northwest, Seneca, Pennsylvania, 16346, United States|UPMC Cancer Center -Robert Eberly Pavilion, Uniontown, Pennsylvania, 15401, United States|UPMC Cancer Center -Uniontown, Uniontown, Pennsylvania, 15401, United States|UPMC Cancer Center -Washington, Washington, Pennsylvania, 15301, United States|UPMC Cancer Center -Wexford, Wexford, Pennsylvania, 15090, United States Less << |
NCT01134666 | Colorectal Neoplasms | TERMINATED | 2014-08-05 | Indo- American Cancer Institut... More >>e & Research Centre, Hyderabad, Andhra Pradesh, 500034, India|NVS Ramakrishna's Clinic, Hyderabad, Andhra Pradesh, 500063, India|Dr. Nikhil's Clinic, Secunderabad, Andhra Pradesh, 500025, India|Nikhil Gharyalpatil's Clinic, Secunderabad, Andhra Pradesh, 500025, India|Ravi Kumar's Clinic, Hyderabad, Andrapradesh, 500001, India|Ambaa Hospitals, Hyderabad, Andrapradesh, 500008, India|Swarna Sai Hospital, Hyderabad, Andrapradesh, 500059, India|Manipal Centre For Clinical Research, Mangalore, Bangalore, 575 001, India|Medical College Calicut, Kerala, Calicut, 673016, India|Hemato Oncology Clinic, Ahmedabad, Gujarat, 380009, India|Kattimani Oncology Clinic, Hubli, Karnataka, 580020, India|SKIMS, Srinagar, Kashmir, 190001, India|S. K. I. M. S., Srinagar, Kashmir, 190010, India|Dr. T. P. Sahoo's Clinic, Bhopal, Madhya Pradesh, 462001, India|BND Onco Centre, Mumbai, Maharashtra, 400014, India|Joy Hospital, Mumbai, Maharashtra, 400071, India|Ruby Hall Clinic, Pune, Maharashtra, 411001, India|Grace Nursing Home, Aizwal, Mizoram, 796 009, India|Lilavati Hospital, Bandra, Mumbai, 400050, India|S.L.Raheja Hospital, Mahim, Mumbai, 400016, India|Apollo Cancer Institute, Delhi, New Delhi, 110044, India|Rajiv Gandhi Cancer Institute & Research, Delhi, New Delhi, 110085, India|Fortis Escorts Hospital, Amritsar, Punjab, 143004, India|Dr. Rajeev Bedi's Clinic, Chandigarh, Punjab, 160101, India|D.M.C Hospital, Ludhiana, Punjab, 141001, India|IVY Hospital, Mohali, Punjab, 160071, India|Cancer Clinic, Jaipur, Rajasthan, 302004, India|SMS Hospital, Jaipur, Rajasthan, 302004, India|Bhagwan Mahaveer Cancer Hospital, Jaipur, Rajasthan, 302006, India|Bhagwan Mahaveer Cancer Hospital & Research Centre, Jaipur, Rajasthan, 302030, India|Vyas Cancer Care, Jodhpur, Rajasthan, 3420003, India|TC 14/ 764 Sreemangalam, Trivandrum, Tamilnadu, 695011, India|Shati Gopal Hospital, Ghaziabad, Uttar Pradesh, 201014, India|Annapurna Medical and Cancer Relief Society, Lucknow, Uttar Pradesh, 226007, India|Chittaranjan National Cancer Institute, Kolkata, West Bengal, 700026, India|Apollo Gleneagles Cancer Hospital, Kolkata, West Bengal, 700054, India|Nothern Railway Central Hospital, Delhi, 110055, India|Indraprastha Apollo Hospital, Delhi, 110076, India|Shanti Mukand Hospital, Delhi, 110092, India|Dharamshila Cancer Hospital & Research Centre, Delhi, 110096, India Less << | |
NCT02636088 | Esophageal Neoplasm | PHASE2 | UNKNOWN | 2025-01-19 | - |
NCT00207116 | Carcinoma, Non-Small-Cell Lung... More >>|Neoplasm Metastasis Less << | PHASE1 | COMPLETED | 2025-03-06 | Local Institution, Newark, Del... More >>aware, United States Less << |
NCT01075841 | Neoplasms, Squamous Cell | WITHDRAWN | - | - | |
NCT00315185 | Carcinoma, Non-Small-Cell Lung | PHASE2 | COMPLETED | 2025-06-08 | Consultants in Medical Oncolog... More >>y & Hematology Inc., Drexel Hill, Pennsylvania, 19026, United States Less << |
NCT01326923 | Head and Neck Squamous Cell Ca... More >>ncer Less << | PHASE2 | TERMINATED | 2025-02-14 | LSU Health Sciences Center, Sh... More >>reveport, Louisiana, 71103, United States Less << |
NCT01074333 | Colorectal Neoplasm | TERMINATED | 2025-01-12 | Asan Medical Center, Seoul, Ko... More >>rea, Republic of Less << | |
NCT01271439 | Nasopharyngeal Carcinoma | PHASE2 | COMPLETED | 2025-12-12 | Cancer Center, Sun Yat-sen Uni... More >>versity, Guangzhou, Guangdong, 510060, China Less << |
NCT00865098 | Carcinoma of the Head and Neck | PHASE2 | COMPLETED | 2025-06-10 | Research Site, Aichi, Japan|Re... More >>search Site, Chiba, Japan|Research Site, Shizuoka, Japan|Research Site, Tokyo, Japan Less << |
NCT00142428 | Hepatocellular Carcinoma | PHASE2 | COMPLETED | 2025-10-08 | Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less << |
NCT01450319 | Colorectal Neoplasms | PHASE2 | COMPLETED | 2025-12-14 | Research Site, A Coru?a, Spain... More >>|Research Site, Asturias, Spain|Research Site, Barcelona, Spain|Research Site, Cordoba, Spain|Research Site, Madrid, Spain|Research Site, Navarra, Spain|Research Site, Santiago de Compostela, Spain|Research Site, Sevilla, Spain|Research Site, Valencia, Spain Less << |
NCT00422773 | Metastatic Colorectal Cancer | PHASE1|PHASE2 | COMPLETED | - | Universitaetsklinikum Carl Gus... More >>tav Carus, Medizinische Klinik, Dresden, Sachsen, 01307, Germany|Westdeutsches Tumorzentrum, Universitaetsklinikum Essen, Essen, 45112, Germany|Universitaetsklinik Mannheim GmbH, III. Medizinische Klinik, Mannheim, 68167, Germany Less << |
NCT00522886 | Non-small Cell Lung Cancer | PHASE1 | COMPLETED | - | Maastricht Radiation Oncology,... More >> MAASTRO clinic, Maastricht, Limburg, Netherlands Less << |
NCT02994888 | Metastatic Colorectal Cancer | COMPLETED | 2025-12-16 | The Royal Marsden NHS Foundati... More >>on Trust, Surrey, Sutton, SM2 5PT, United Kingdom Less << | |
NCT04853043 | Colorectal Cancer | PHASE2 | TERMINATED | 2024-05-03 | Intermountain Medical Center, ... More >>Salt Lake City, Utah, 84107, United States|Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah, 84112, United States Less << |
NCT06226857 | Colorectal Neoplasms|Chemother... More >>apy Effect|Molecular Sequence Variation Less << | PHASE3 | RECRUITING | 2027-12-31 | Moscow Multidiciplinary Clinic... More >>al Center Kommunarka, Moscow, 108814, Russian Federation|N.N Blokhin Cancer Reserch Center, Moscow, 115478, Russian Federation|Reutov Clinical hospital, Reutov, 143964, Russian Federation Less << |
NCT04648189 | Lung Cancer|Surgery|Circulatin... More >>g Tumor Cell Less << | PHASE2 | WITHDRAWN | 2022-09-19 | Amsterdam UMC - VUMC, Amsterda... More >>m, Netherlands|Leiden University Medical Center, Leiden, Netherlands Less << |
NCT01830556 | Squamous Cell Carcinoma of the... More >> Head and Neck Less << | PHASE2 | UNKNOWN | 2025-11-15 | Lena Specht, Copenhagen, 2100,... More >> Denmark|Hedda Haugen, G?teborg, 413 45, Sweden|Karolinska Universityhospital, Stockholm, 17176, Sweden|Karin S?derstr?m, Ume?, 90189, Sweden|Akademiska Universityhospital, Uppsala, 751 85, Sweden Less << |
NCT01435252 | Oropharyngeal Cancer|Hypophary... More >>ngeal Cancer|Laryngeal Cancer Less << | PHASE2 | COMPLETED | 2017-10-25 | University Hospital, Zurich, S... More >>witzerland Less << |
NCT01230476 | Nasopharyngeal Carcinoma | PHASE2 | TERMINATED | 2025-05-15 | University Malaya Medical Cent... More >>re, Kuala Lumpur, Wilayah Persekutuan, 59100, Malaysia Less << |
NCT00251485 | Colorectal Cancer | PHASE2 | COMPLETED | 2025-06-05 | Veeda Oncology, Houston, Texas... More >>, 77042, United States Less << |
NCT06440902 | Colorectal Cancer Metastatic | PHASE2 | RECRUITING | 2028-09-01 | Fudan University Shanghai Canc... More >>er Center, Shanghai, Shanghai, 200032, China Less << |
NCT00130689 | Esophageal Cancer|Gastric Canc... More >>er|Neoplasm Metastasis Less << | PHASE2 | COMPLETED | 2025-09-10 | Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States|North Shore Medical Center Cancer Center, Peabody, Massachusetts, United States Less << |
NCT00215722 | Colorectal Carcinoma | PHASE2 | UNKNOWN | 2025-07-08 | Hospital Garcia de Orta, Almad... More >>a, 2800, Portugal|Hospital Distrital do Barreiro, Barreiro, 2830, Portugal|Hospital Distrital de Beja, Beja, 7800-309, Portugal|Hospital de S?o Marcos, Braga, 4700, Portugal|Hospitais da Universidade de Coimbra, Coimbra, 3000-075, Portugal|IPO - Coimbra, Coimbra, 3000, Portugal|Centro Hospitalar do Funchal, Funchal, 9000-514, Portugal|Hospital Pedro Hispano, Matosinhos, 4454-509, Portugal|Hospital do Divino Espírito Santo, Ponta Delgada, 9500-370, Portugal|IPO - Porto, Porto, 4200, Portugal Less << |
NCT00292955 | Cancer of the Cervix | PHASE2 | UNKNOWN | - | Washinton University School of... More >> Medicine, St. Louis, Missouri, 63110, United States|University of Virginia Cancer Center, Charlottesville, Virginia, 22908, United States Less << |