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Chemical Structure| 1338806-73-7 Chemical Structure| 1338806-73-7

Structure of CFI-400945
CAS No.: 1338806-73-7

Chemical Structure| 1338806-73-7

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CFI400945 is a potent and selective,orally bioavailable PLK4 inhibitor with an IC50 value of 2.8 ±1.4 nM have potential antineoplastic activity.

4.5 *For Research Use Only !

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Product Details of CFI-400945

CAS No. :1338806-73-7
Formula : C33H34N4O3
M.W : 534.65
SMILES Code : O=C([C@@]12[C@H](C3=CC4=C(C=C3)C(/C=C/C5=CC=C(CN6C[C@@H](C)O[C@@H](C)C6)C=C5)=NN4)C1)NC7=C2C=C(OC)C=C7
MDL No. :MFCD28386170
InChI Key :DADASRPKWOGKCU-FVTQAUBDSA-N
Pubchem ID :58486178

Safety of CFI-400945

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • PLK4

    PLK4, IC50:2.8 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01954316 Advanced Cancer PHASE1 COMPLETED 2021-07-22 UCLA Medical Center, Santa Mon... More >>ica, California, 90404, United States|Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada Less <<
NCT03624543 Breast Cancer PHASE2 ACTIVE_NOT_RECRUITING 2025-12-31 Juravinski Cancer Centre at Ha... More >>milton Health Sciences, Hamilton, Ontario, L8V 5C2, Canada|London Regional Cancer Program, London, Ontario, N6A 5W9, Canada|Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8L6, Canada|Odette Cancer Centre, Toronto, Ontario, M4N 3M5, Canada|University Health Network, Toronto, Ontario, M5G 2M9, Canada|Allan Blair Cancer Centre, Regina, Saskatchewan, S4T 7T1, Canada Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.35mL

1.87mL

0.94mL

18.70mL

3.74mL

1.87mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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