CFL-120 | Indolines | Ambeed.com

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Quality Control of CFL-120 Purity: 98% SDS Specification

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NMR

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Product Details of CFL-120

CAS No. :	18711-15-4
Formula :	C₈H₃Cl₂NO₂
M.W :	216.02
SMILES Code :	C1=C(C=C(C2=C1NC(C2=O)=O)Cl)Cl
MDL No. :	MFCD01971146
Boiling Point :	No data available
InChI Key :	CGCVHJCZBIYRQC-UHFFFAOYSA-N
Pubchem ID :	251908

Safety of CFL-120

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P261-P302+P352-P305+P351+P338

Application In Synthesis of CFL-120

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 18711-15-4 ]

[ 18711-15-4 ] Synthesis Path-Downstream 1~35

1
[ 18711-15-4 ]
[ 626-43-7 ]
4,6-dichloro-3-(3,5-dichloro-phenylimino)-indolin-2-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1956,vol. 21,p. 171.

2
[ 18711-15-4 ]
[ 20776-63-0 ]

Yield	Reaction Conditions	Operation in experiment
82%	With sodium hydroxide; dihydrogen peroxide; In water; for 2h;	At room temperature, to a solution of the intermediate I-2 (5.0 g, 23.1 mmol) prepared by the above peparation example I(2) in 75 mL 1N NaOH (aq) was added portionwise hydrogen peroxide (28% v/v, 10 mL). The reaction mixture was filtered after stirring for 2 hours to remove insoluble dark brown solid. The filterate was then carefully acidified to pH 2 by conc. hydrochloric acid. The formed yellow precipitates were collected, washed with water, and dried in vacuo. The objective compound (3.90 g, 82%) was obtained as ivory-colored solid by recrystalization from benzene: TLC Rf=0.1 (EtOAc:n-hexane=1:1); m.p. 188-189 C.; 1H NMR (DMSO-d6) delta 6.76 (d, J=1.9 Hz, 1H, ArH), 6.85 (d, J=1.9 Hz, 1H, ArH); MS (EI) m/e 206 [M+], 162 [M+-CO2].
82%		3) Intermediate I-3; 2-amino-4,6-dichloro benzoic acid; At room temperature, to a solution of the intermediate I-2 (5.0 g, 23.1 mmol) prepared by the above peparation example I(2) in 75 mL 1N NaOH (aq) was added portionwise hydrogen peroxide (28 % v/v, 10 mL). The reaction mixture was filtered after stirring for 2 hours to remove insoluble dark brown solid. The filterate was then carefully acidified to pH 2 by conc. hydrochloric acid. The formed yellow precipitates were collected, washed with water, and dried in vacuo. The objective compound (3.90 g, 82 %) was obtained as ivory-colored solid by recrystalization from benzene: TLC Rf = 0.1 (EtOAc:n-hexane = 1:1); m.p. 188 - 189 C; 1H NMR (DMSO-d6) delta 6.76 (d, J = 1. 9 Hz, 1H, ArH), 6.85 (d, J = 1. 9 Hz, 1H, ArH); MS(EI) m/e 206[M+], 162[M+-CO2].
82%		Step 3: Preparation of 2-amino-4,6-dichlorobenzoic acidTo a solution of 4,6-dihloro-lH-indole-2,3-dione (5.0 g, 23.1 mmol) in 75 ml of 1 N <n="28"/>NaOH was partially added hydrogen peroxide (28 % v/v, 10 ml) at room temperature. After stirring the mixture for 2 hours, an insoluble dark brown solid was removed by filtration. The filtrate was acidified with a cone, hydrochloric acid to a pH of 2. The yellow precipitate thus formed was harvested, washed with distilled water, and dried in a vacuum. Recrystallization in benzene produced the title compound as an ivory solid (3.90 g, 82%).TLC Rf= 0.1 (ethylacetate : n-hexane = 1:1); m.p. 188 - 189 C;1HNMR (DMSO-de) delta 6.76 (d, IH5J= 1.9 Hz5 ArH), 6.85 (d, IH5J= 1.9 Hz5 ArH);MS(EI) m/e 206 [M+], 162 [M+-CO2].

82%

Step 3 Preparation of 2-amino-4,6-dichlorobenzoic acid To a solution of 4,6-dihloro-1H-indole-2,3-dione (5.0 g, 23.1 mmol) in 75 ml of 1 N NaOH was partially added hydrogen peroxide (28% v/v, 10 ml) at room temperature. After stirring the mixture for 2 hours, an insoluble dark brown solid was removed by filtration. The filtrate was acidified with a cone, hydrochloric acid to a pH of 2. The yellow precipitate thus formed was harvested, washed with distilled water, and dried in a vacuum. Recrystallization in benzene produced the title compound as an ivory solid (3.90 g, 82%). TLC Rf=0.1 (ethylacetate: n-hexane=1:1); m.p. 188-189 C.; 1H NMR (DMSO-d6) delta 6.76 (d, 1H, J=1.9 Hz, ArH), 6.85 (d, 1H, J=1.9 Hz, ArH); MS (EI) m/e 206 [M+], 162 [M+-CO2].

References: [1]Patent: US2006/84676,2006,A1 .Location in patent: Page/Page column 7.
[2]Patent: EP1650190,2006,A1 .Location in patent: Page/Page column 10.
[3]Patent: WO2008/4716,2008,A1 .Location in patent: Page/Page column 25-26.
[4]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 738 - 743.
[5]Patent: US2009/203708,2009,A1 .Location in patent: Page/Page column 8.
[6]Journal of the American Chemical Society,1956,vol. 78,p. 1251,1254.

3
[ 18711-11-0 ]
[ 18711-15-4 ]

Yield	Reaction Conditions	Operation in experiment
96%	With sulfuric acid; at 0 - 90℃;	2) Intermediate I-2; 4,6-dichloro-1H-indole-2,3-dione; The Intermediate I-1 (10.0 g, 42.9 mmol) prepared by the above preparation example I(1) was slowly added to conc. sulfuric acid (50 mL) in an ice bath. At this moment, the temperature of the reaction mixture was maintained below 50C. After complete the addition, the solution of dark color was heated for 10 minutes at 90 C. After cooling down the resultant to room temperature, the reactant was poured into ice having 10 times of the reactant volume, and was vigorously stirred for 1 hour. The insoluble solid formed in the above procedure was collected, washed with water, dried in vacuo, and the objective compound (8.90 g, 96 %) was obtained as orange-colored solid: TLC Rf = 0.4 (EtOAc:n-hexane = 1:3); mp 228-230 ; 1H NMR (DMSO-d6) delta 6.97 (d, J = 1.8 Hz, 1H, ArH), 7.32 (d, J = 1.8 Hz, 1H, ArH), 11.42 (br s, 1H, NH); MS (EI) m/e 216[M+], 188 [M+-CO2], 160.
96%	With sulfuric acid; at 0 - 90℃; for 1h;	Step 2: Preparation of 4,6-dichloro-lH-indole-2,3-dione N-(3,5-dicUorophenyl)-2-hydroxyimino-acetamide (10.0 g, 42.9 mmol), prepared in step 1, was slowly added to cone, sulfuric acid (50 ml) in an ice bath. At this time, the reaction mixture was required to be maintained at 5O0C or less. Following completion of the addition, the turbid solution was heated to 9O0C for 1 hour with stirring. The resulting reaction mixture was cooled to room temperature and then added to 10 volumes of crushed ice blocks and stirred for 1 hour. The insoluble solid thus formed was harvested, washed with distilled water and dried in a vacuum to give the title compound as an orange solid (8.90 g, 96%). TLC Rf= 0.4 (ethylacetate:n-hexane = 1 :3); mp 228-2300C;1H NMR (DMSO-d6)delta 6.97 (d, IH, J= 1.8 Hz, ArH), 7.32 (d, IH, J= 1.8 Hz, ArH), 11.42 (br s, IH5NH);MS(EI) m/e 216 [M+], 188 [M+-CO2], 160.
96%	With sulfuric acid; at 50 - 90℃;Cooling with ice;	Step 2 Preparation of 4,6-dichloro-1H-indole-2,3-dione N-(3,5-dichlorophenyl)-hydroxyimino-acetamide (10.0 g, 42.9 mmol), prepared in step 1, was slowly added to cone, sulfuric acid (50 ml) in an ice bath. At this time, the reaction mixture was required to be maintained at 50 C. or less. Following completion of the addition, the turbid solution was heated to 90 C. for 1 hour with stirring. The resulting reaction mixture was cooled to room temperature and then added to 10 volumes of crushed ice blocks and stirred for 1 hour. The insoluble solid thus formed was harvested, washed with distilled water and dried in a vacuum to give the title compound as an orange solid (8.90 g, 96%). TLC Rf=0.4 (ethylacetate:n-hexane=1:3); mp 228-230 C.; 1H NMR (DMSO-d6) delta 6.97 (d, 1H, J=1.8 Hz, ArH), 7.32 (d, 1H, J=1.8 Hz, ArH), 11.42 (br s, 1H, NH); MS (EI) m/e 216 [M+], 188 [M+-CO2], 160.

References: [1]Patent: EP1650190,2006,A1 .Location in patent: Page/Page column 10.
[2]Patent: WO2008/4716,2008,A1 .Location in patent: Page/Page column 25.
[3]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 738 - 743.
[4]Patent: US2009/203708,2009,A1 .Location in patent: Page/Page column 8.
[5]Helvetica Chimica Acta,1919,vol. 2,p. 239.

4
[ 623-73-4 ]
[ 18711-15-4 ]
Diazo-(4,6-dichloro-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-acetic acid ethyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 499 - 504.

5
[ 18711-15-4 ]
[ 56023-96-2 ]
3-Diazo-3-(4,6-dichloro-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-oxo-propionic acid methyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 499 - 504.

6
[ 18711-15-4 ]
[ 14214-10-9 ]
3-Diazo-3-(4,6-dichloro-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-oxo-propionic acid ethyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 499 - 504.

7
[ 18711-15-4 ]
[ 36261-17-3 ]
2-(5,7-Dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-N-methyl-2-oxo-acetamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 499 - 504.

8
[ 18711-15-4 ]
3-Diazo-2-oxo-N-phenyl-propionamide [ No CAS ]
2-(5,7-Dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-2-oxo-N-phenyl-acetamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 499 - 504.

9
[ 18711-15-4 ]
[ 112734-23-3 ]

Yield	Reaction Conditions	Operation in experiment
72%	With acetic anhydride; In acetic acid;	a. 5,7-Dichloro-2H-3,1-benzoxazine-2,4(1H)-dione To a stirred solution of <strong>[18711-15-4]4,6-dichloro-1H-indole-2,3-dione</strong> (5.00 g, 23.2 mM) in acetic acid (21 mL) and acetic anhydride (21 mL) at 80 C. was added in small portions chromium trioxide (4.12 g, 41.3 mM). The temperature of the reaction mixture was maintained between 80-90 C. during the addition of the chromium trioxide. After the addition was complete, the reaction mixture was diluted with water (100 mL) and then filtered to separate the precipitated solids. The solids were washed thoroughly with water and then dried to obtain the title compound as a yellow solid (4.13 g, 72%); MS(CI): 232 (M+H).
	In acetic acid;	PREPARATION 10 To a suspension of <strong>[18711-15-4]4,6-dichloroindolin-2,3-dione</strong> (5.95 g) in acetic acid (95 ml) was added chromium trioxide (16 g) over a period of 15 minutes at 60 C. with stirring and the mixture was stirred at 70-75 C. for 1 hour. After cooling, the reaction mixture was poured into water (360 ml) and the resulting precipitates were collected by filtration. The filtrate was extracted with ethyl acetate. The extract was washed with water and dried. Removal of the solvent gave a residue, which was combined with the precipitates. Recrystallization from isopropyl ether gave 5,7-dichloro-2H-3,1-benzoxazine-2,4(1H)-dione (2.85 g). mp: 267-268 C. IR (Nujol): 3225, 3200, 3100, 3075, 1790, 1775, 1705, 1610, 1585 cm-1. NMR (DMSO-d6, delta): 7.09 (1H, d, J=1.2 Hz), 7.48 (1H, d, J=1.2 Hz).

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.
[2]Patent: US5599814,1997,A .
[3]Patent: US4734419,1988,A .

10
[ 18711-15-4 ]
[ 6832-16-2 ]
[ 185804-83-5 ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

11
[ 623-73-4 ]
[ 18711-15-4 ]
[ 176170-05-1 ]
5,7-dichloro-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

13
oxalic acid-<3,5-dichloro-anilide>-nitrile [ No CAS ]
[ 18711-15-4 ]

References: [1]Patent: DE541924,1928, .
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 18,p. 643.

14
[ 18711-15-4 ]
[ 99-90-1 ]
2-(4-bromo-phenyl)-5,7-dichloro-quinoline-4-carboxylic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2001,vol. 11,p. 541 - 544.

15
[ 18711-15-4 ]
[ 106-48-9 ]
(+/-)-3-(5-chloro-2-hydroxyphenyl)-4,6-dichloro-1,3-dihydro-3-hydroxy-2H-indol-2-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 1487 - 1499.
[2]Journal of Medicinal Chemistry,2002,vol. 45,p. 1487 - 1499.

16
[ 18711-15-4 ]
(6,8-dichloro-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-methanol [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

17
[ 18711-15-4 ]
(6,8-dichloro-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-acetic acid methyl ester [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

18
[ 18711-15-4 ]
[ 185804-80-2 ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

19
[ 18711-15-4 ]
(5,7-dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-acetic acid [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

20
[ 18711-15-4 ]
[ 185804-51-7 ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

21
[ 18711-15-4 ]
methanesulfonic acid 6,8-dichloro-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-ylmethyl ester [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

22
[ 18711-15-4 ]
2-(5,7-dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-N-methyl-acetamide [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

23
[ 18711-15-4 ]
2-(5,7-dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-N-ethyl-N-methyl-acetamide [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

24
[ 18711-15-4 ]
2-(5,7-dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-N-ethyl-acetamide [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

25
[ 18711-15-4 ]
N-allyl-2-(5,7-dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-acetamide [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

26
[ 18711-15-4 ]
2-(5,7-dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-N-propyl-acetamide [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

27
[ 18711-15-4 ]
2-(5,7-dichloro-3-hydroxy-2-oxo-1,2-dihydro-quinolin-4-yl)-N-(2-fluoro-ethyl)-acetamide [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

28
[ 18711-15-4 ]
5,7-dichloro-3-hydroxy-4-(2-morpholin-4-yl-2-oxo-ethyl)-1H-quinolin-2-one [ No CAS ]

References: [1]Medicinal Chemistry Research,1996,vol. 6,p. 581 - 592.

29
[ 18711-15-4 ]
[ 195253-38-4 ]

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.

30
[ 18711-15-4 ]
[ 195253-17-9 ]

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.

31
[ 18711-15-4 ]
[ 195253-11-3 ]

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.

32
[ 18711-15-4 ]
[ 195253-41-9 ]

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.

33
[ 18711-15-4 ]
2-Amino-4,6-dichloro-N-m-tolyl-benzamide [ No CAS ]

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.

34
[ 18711-15-4 ]
[ 195253-13-5 ]

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.

35
[ 18711-15-4 ]
2-Amino-4,6-dichloro-benzoic acid [1-phenyl-meth-(E)-ylidene]-hydrazide [ No CAS ]

References: [1]Archiv der Pharmazie,1997,vol. 330,p. 129 - 134.

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 18711-15-4

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CAS No.: 18711-15-4

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[ 18711-15-4 ] Synthesis Path-Downstream 1~35

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