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Chemical Structure| 2882165-79-7 Chemical Structure| 2882165-79-7

Structure of CFT1946
CAS No.: 2882165-79-7

Chemical Structure| 2882165-79-7

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CFT1946 is an orally active, CRBN-based, mutation-selective BRAFV600E BiDAC™ degrader with a DC50 of 14 nM in A375 cells. It degrades BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and p61-BRAFV600E splice variants, while maintaining excellent selectivity against the proteome, including WT BRAF and CRAF. CFT1946 can be used in oncology research.

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Product Details of CFT1946

CAS No. :2882165-79-7
Formula : C45H49F2N11O9S
M.W : 958.00
SMILES Code : CN1C=2C(C(=N1)N3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCC(CC(=O)N5CCC6(CC5)C[C@H](CO6)N7C(=O)C=8C(N=C7)=CC=C(OC9=C(C#N)C(NS(N(CC)C)(=O)=O)=CC=C9F)C8)(O)CC4
MDL No. :N/A

Safety of CFT1946

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of CFT1946

MAPK

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.04mL

0.21mL

0.10mL

5.22mL

1.04mL

0.52mL

10.44mL

2.09mL

1.04mL

 

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