Structure of Chlorhexidine
CAS No.: 55-56-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Chlorhexidine is an antibacterial used as an antiseptic and for other applications.
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| CAS No. : | 55-56-1 |
| Formula : | C22H30Cl2N10 |
| M.W : | 505.45 |
| SMILES Code : | N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N |
| MDL No. : | MFCD00009673 |
| InChI Key : | GHXZTYHSJHQHIJ-UHFFFAOYSA-N |
| Pubchem ID : | 9552079 |
| GHS Pictogram: |
|
| Signal Word: | Danger |
| Hazard Statements: | H315-H319-H334-H335-H410 |
| Precautionary Statements: | P261-P273-P305+P351+P338-P342+P311-P501 |
| Class: | 9 |
| UN#: | 3077 |
| Packing Group: | Ⅲ |
In Vitro:
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Cell Line
|
Concentration | Treated Time | Description | References |
| Acinetobacter baumannii | 8 µM | 30 min | To investigate the role of AceR in regulating aceI gene expression under chlorhexidine induction. Results showed that chlorhexidine induced a 34-fold increase in aceI gene expression in the WT strain, while this induction was abolished in the DaceR mutant strain. | J Antimicrob Chemother. 2018 Jun 1;73(6):1492-1500. |
In Vivo:
|
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
| Mice | Partial ischemia-reperfusion injury model | Topical disinfection | 0.5% in 70% Ethanol | Single use | Used for topical disinfection before surgery | Nat Commun. 2023 Jul 21;14(1):4407 |
| C57BL/6J mice | Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) model | Oral rinse | 0.12% | Once on day 5 | Suppress existing oral bacteria and facilitate subsequent bacterial colonization | Int J Mol Sci. 2022 May 4;23(9):5107 |
| Mice | Pain model | Intrathecal injection | 0.025 to 0.75 mg/kg | Single injection, lasting 4 hours | To evaluate the analgesic effect of Consomatin Ro1, results showed dose-dependent antinociception when injected intraperitoneally but no significant effect when injected intrathecally. | Sci Adv. 2022 Mar 25;8(12):eabk1410 |
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT03401801 | Neuropathic Pain | Not Applicable | Recruiting | February 17, 2019 | Korea, Republic of ... More >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Jee Youn Moon, M.D. 82-10-5299-2036 jymoon0901@gmail.com Principal Investigator: Jee Youn Moon, M.D. Less << |
| NCT02662374 | Oral Mucositis | Phase 4 | Unknown | May 2016 | - |
| NCT03161717 | Epidural Analgesia | Not Applicable | Recruiting | March 2019 | Korea, Republic of ... More >> Korea University Guro Hospital Recruiting Seoul, Korea, Republic of, 08308 Contact: Seung-hoe Song, MBE 82-2-2626-1635 ssessong@korea.ac.kr Contact: Da-in Lee 82-2-2626-2279 0124dain@gmail.com Principal Investigator: Sang Sik Choi, MD, PhD Sub-Investigator: Chung Hun Lee, MD Sub-Investigator: Mi Kyoung Lee, MD, PhD Less << |
| NCT03093194 | A Known Allergy to Antiseptic ... More >>Soap Women Who Had Any Infection in the Perioperative Period A Known Allergy to Chlorohexidine Alcohol or Shellfis Less << | Not Applicable | Not yet recruiting | April 30, 2020 | - |
| NCT03640507 | Cesarean Section; Infection ... More >> Surgical Site Infection Less << | Phase 2 Phase 3 | Recruiting | June 2019 | United States, New York ... More >> New York Presbyterian Hospital at Columbia University and Children's Hospital of New York Recruiting New York, New York, United States, 10032 Contact: Cassandra R. Duffy, MD 929-286-0292 crd2130@columbia.edu Less << |
| NCT02628938 | Oral Malodor ... More >>Halitosis Less << | Phase 2 | Completed | - | Saudi Arabia ... More >> Riyadh colleges of dentistry and pharmacy Riyadh, Saudi Arabia, 11681 Less << |
| NCT02385708 | Surgical Site Infection | Not Applicable | Completed | - | United States, Tennessee ... More >> Vanderbilt University Nashville, Tennessee, United States, 37212 Less << |
| NCT02628938 | - | Completed | - | - | |
| NCT03590977 | Caries, Dental | Not Applicable | Not yet recruiting | October 1, 2019 | - |
| NCT03195582 | Implant Infection ... More >> Bone Loss Less << | Phase 1 Phase 2 | Not yet recruiting | December 2018 | - |
| NCT03115892 | Halitosis | Phase 1 Phase 2 | Enrolling by invitation | December 1, 2017 | Egypt ... More >> Oral An Dental Medicine Faculty Cairo, Egypt Less << |
| NCT02132546 | Staining Effect of Chlorhexidi... More >>ne Less << | PHASE2 | COMPLETED | 2025-09-12 | Ospedale Maggiore, Trieste, It... More >>aly Less << |
| NCT04171817 | Methicillin-resistant Staphylo... More >>coccus Aureus|Clostridium Difficile|Pseudomonas Aeruginosa Less << | PHASE4 | RECRUITING | 2026-12-01 | Johns Hopkins, Baltimore, Mary... More >>land, 21205, United States|Washington University in St. Louis, Saint Louis, Missouri, 63110, United States|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States Less << |
| NCT00198679 | Skin Diseases, Infectious | PHASE4 | COMPLETED | 2025-03-05 | Dhaka Shishu Hospital, Dhaka, ... More >>Bangladesh Less << |
| NCT00223002 | Asepsis|Analgesia, Epidural|An... More >>esthesia, Epidural Less << | COMPLETED | 2025-01-08 | Royal University Hospital, Sas... More >>katoon, Saskatchewan, S7N 0W8, Canada Less << |
Tags: Chlorhexidine | Bacterial | Antibiotic | antiseptic | antimicrobial | bacterial cell membrane disruption | Antibacterial | Antimicrobial | Anti-infective agent | Antibiotic | Antibacterial | Bacteriostatic | Bactericidal | Antibiotic resistance | fungi infection | virus infection | 55-56-1
Precautionary Statements-General | |
| Code | Phrase |
| P101 | If medical advice is needed,have product container or label at hand. |
| P102 | Keep out of reach of children. |
| P103 | Read label before use |
Prevention | |
| Code | Phrase |
| P201 | Obtain special instructions before use. |
| P202 | Do not handle until all safety precautions have been read and understood. |
| P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
| P211 | Do not spray on an open flame or other ignition source. |
| P220 | Keep/Store away from clothing/combustible materials. |
| P221 | Take any precaution to avoid mixing with combustibles |
| P222 | Do not allow contact with air. |
| P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
| P230 | Keep wetted |
| P231 | Handle under inert gas. |
| P232 | Protect from moisture. |
| P233 | Keep container tightly closed. |
| P234 | Keep only in original container. |
| P235 | Keep cool |
| P240 | Ground/bond container and receiving equipment. |
| P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
| P242 | Use only non-sparking tools. |
| P243 | Take precautionary measures against static discharge. |
| P244 | Keep reduction valves free from grease and oil. |
| P250 | Do not subject to grinding/shock/friction. |
| P251 | Pressurized container: Do not pierce or burn, even after use. |
| P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
| P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
| P262 | Do not get in eyes, on skin, or on clothing. |
| P263 | Avoid contact during pregnancy/while nursing. |
| P264 | Wash hands thoroughly after handling. |
| P265 | Wash skin thouroughly after handling. |
| P270 | Do not eat, drink or smoke when using this product. |
| P271 | Use only outdoors or in a well-ventilated area. |
| P272 | Contaminated work clothing should not be allowed out of the workplace. |
| P273 | Avoid release to the environment. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
| P281 | Use personal protective equipment as required. |
| P282 | Wear cold insulating gloves/face shield/eye protection. |
| P283 | Wear fire/flame resistant/retardant clothing. |
| P284 | Wear respiratory protection. |
| P285 | In case of inadequate ventilation wear respiratory protection. |
| P231 + P232 | Handle under inert gas. Protect from moisture. |
| P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
| Code | Phrase |
| P301 | IF SWALLOWED: |
| P304 | IF INHALED: |
| P305 | IF IN EYES: |
| P306 | IF ON CLOTHING: |
| P307 | IF exposed: |
| P308 | IF exposed or concerned: |
| P309 | IF exposed or if you feel unwell: |
| P310 | Immediately call a POISON CENTER or doctor/physician. |
| P311 | Call a POISON CENTER or doctor/physician. |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
| P313 | Get medical advice/attention. |
| P314 | Get medical advice/attention if you feel unwell. |
| P315 | Get immediate medical advice/attention. |
| P320 | |
| P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
| P321 | |
| P322 | |
| P330 | Rinse mouth. |
| P331 | Do NOT induce vomiting. |
| P332 | IF SKIN irritation occurs: |
| P333 | If skin irritation or rash occurs: |
| P334 | Immerse in cool water/wrap n wet bandages. |
| P335 | Brush off loose particles from skin. |
| P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
| P337 | If eye irritation persists: |
| P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
| P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P342 | If experiencing respiratory symptoms: |
| P350 | Gently wash with plenty of soap and water. |
| P351 | Rinse cautiously with water for several minutes. |
| P352 | Wash with plenty of soap and water. |
| P353 | Rinse skin with water/shower. |
| P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
| P361 | Remove/Take off immediately all contaminated clothing. |
| P362 | Take off contaminated clothing and wash before reuse. |
| P363 | Wash contaminated clothing before reuse. |
| P370 | In case of fire: |
| P371 | In case of major fire and large quantities: |
| P372 | Explosion risk in case of fire. |
| P373 | DO NOT fight fire when fire reaches explosives. |
| P374 | Fight fire with normal precautions from a reasonable distance. |
| P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
| P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
| P378 | |
| P380 | Evacuate area. |
| P381 | Eliminate all ignition sources if safe to do so. |
| P390 | Absorb spillage to prevent material damage. |
| P391 | Collect spillage. Hazardous to the aquatic environment |
| P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
| P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
| P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
| P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
| P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
| P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
| P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
| P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
| P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
| P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
| P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
| P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
| P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
| P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
| P370 + P376 | In case of fire: Stop leak if safe to Do so. |
| P370 + P378 | In case of fire: |
| P370 + P380 | In case of fire: Evacuate area. |
| P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
| P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
| Code | Phrase |
| P401 | |
| P402 | Store in a dry place. |
| P403 | Store in a well-ventilated place. |
| P404 | Store in a closed container. |
| P405 | Store locked up. |
| P406 | Store in corrosive resistant/ container with a resistant inner liner. |
| P407 | Maintain air gap between stacks/pallets. |
| P410 | Protect from sunlight. |
| P411 | |
| P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
| P413 | |
| P420 | Store away from other materials. |
| P422 | |
| P402 + P404 | Store in a dry place. Store in a closed container. |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
| P403 + P235 | Store in a well-ventilated place. Keep cool. |
| P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
| P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
| P411 + P235 | Keep cool. |
Disposal | |
| Code | Phrase |
| P501 | Dispose of contents/container to ... |
| P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
| Code | Phrase |
| H200 | Unstable explosive |
| H201 | Explosive; mass explosion hazard |
| H202 | Explosive; severe projection hazard |
| H203 | Explosive; fire, blast or projection hazard |
| H204 | Fire or projection hazard |
| H205 | May mass explode in fire |
| H220 | Extremely flammable gas |
| H221 | Flammable gas |
| H222 | Extremely flammable aerosol |
| H223 | Flammable aerosol |
| H224 | Extremely flammable liquid and vapour |
| H225 | Highly flammable liquid and vapour |
| H226 | Flammable liquid and vapour |
| H227 | Combustible liquid |
| H228 | Flammable solid |
| H229 | Pressurized container: may burst if heated |
| H230 | May react explosively even in the absence of air |
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
| H240 | Heating may cause an explosion |
| H241 | Heating may cause a fire or explosion |
| H242 | Heating may cause a fire |
| H250 | Catches fire spontaneously if exposed to air |
| H251 | Self-heating; may catch fire |
| H252 | Self-heating in large quantities; may catch fire |
| H260 | In contact with water releases flammable gases which may ignite spontaneously |
| H261 | In contact with water releases flammable gas |
| H270 | May cause or intensify fire; oxidizer |
| H271 | May cause fire or explosion; strong oxidizer |
| H272 | May intensify fire; oxidizer |
| H280 | Contains gas under pressure; may explode if heated |
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
| H290 | May be corrosive to metals |
Health hazards | |
| Code | Phrase |
| H300 | Fatal if swallowed |
| H301 | Toxic if swallowed |
| H302 | Harmful if swallowed |
| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
| H310 | Fatal in contact with skin |
| H311 | Toxic in contact with skin |
| H312 | Harmful in contact with skin |
| H313 | May be harmful in contact with skin |
| H314 | Causes severe skin burns and eye damage |
| H315 | Causes skin irritation |
| H316 | Causes mild skin irritation |
| H317 | May cause an allergic skin reaction |
| H318 | Causes serious eye damage |
| H319 | Causes serious eye irritation |
| H320 | Causes eye irritation |
| H330 | Fatal if inhaled |
| H331 | Toxic if inhaled |
| H332 | Harmful if inhaled |
| H333 | May be harmful if inhaled |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| H335 | May cause respiratory irritation |
| H336 | May cause drowsiness or dizziness |
| H340 | May cause genetic defects |
| H341 | Suspected of causing genetic defects |
| H350 | May cause cancer |
| H351 | Suspected of causing cancer |
| H360 | May damage fertility or the unborn child |
| H361 | Suspected of damaging fertility or the unborn child |
| H361d | Suspected of damaging the unborn child |
| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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