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Chemical Structure| 156951-82-5 Chemical Structure| 156951-82-5

Structure of Chrysotoxine
CAS No.: 156951-82-5

Chemical Structure| 156951-82-5

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Chrysotoxine is a dual inhibitor of Src and Akt, capable of downregulating the Src/Akt signaling pathway to inhibit cancer stem cell (CSC) phenotypes. It reduces the viability of H460 and H23 lung cancer cells while increasing apoptosis levels without significant effects on non-tumor cells, showing potential for cancer-related research.

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Product Details of Chrysotoxine

CAS No. :156951-82-5
Formula : C18H22O5
M.W : 318.36
SMILES Code : OC1=C(OC)C=C(CCC2=CC=C(OC)C(OC)=C2)C=C1OC
MDL No. :MFCD22200427
InChI Key :YUHRVKGYFHPWRI-UHFFFAOYSA-N
Pubchem ID :5315860

Safety of Chrysotoxine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Related Pathways of Chrysotoxine

RTK
PI3K-AKT

Isoform Comparison

Biological Activity

Description
Chrysotoxine inhibits both Src and Akt. It decreases the characteristics of cancer stem cells (CSCs) by lowering Src/Akt signaling. Chrysotoxine decreases cell viability and boosts apoptosis in H460 and H23 cells, but not in non-tumor cell lines. It exhibits quick excretion and limited bioavailability in rats. Chrysotoxine is employed in cancer[1][2].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.71mL

3.14mL

1.57mL

31.41mL

6.28mL

3.14mL

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