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Chemical Structure| 1370554-01-0 Chemical Structure| 1370554-01-0

Structure of Ciliobrevin D
CAS No.: 1370554-01-0

Chemical Structure| 1370554-01-0

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Ciliobrevin D is a highly cell-permeable, reversible, and specific AAA+ ATPase inhibitor that targets cytoplasmic dynein.

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Product Details of Ciliobrevin D

CAS No. :1370554-01-0
Formula : C17H8Cl3N3O2
M.W : 392.62
SMILES Code : O=C(/C(C#N)=C(NC1=CC(Cl)=CC=C12)\NC2=O)C3=C(Cl)C=C(C=C3)Cl
MDL No. :MFCD32671360

Safety of Ciliobrevin D

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H318-H410
Precautionary Statements:P273-P280-P301+P312+P330-P305+P351+P338+P310
Class:9
UN#:3077
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
MOLT3 cells 20 µM 24 h Inhibition of dynein rescues Notch3 surface levels Oncogene. 2018 Jul;37(28):3839-3851.
eNK cells 25, 50, or 100 µM 30 min Blocked lytic granule convergence to MTOC, increased granule dispersion J Cell Biol. 2016 Dec 19;215(6):875-889.
NK92 cells 25, 50, or 100 µM 30 min Blocked lytic granule convergence to MTOC, increased granule dispersion J Cell Biol. 2016 Dec 19;215(6):875-889.
YTS cells 25, 50, or 100 µM 30 min Blocked lytic granule convergence to MTOC, increased granule dispersion J Cell Biol. 2016 Dec 19;215(6):875-889.
hTERT RPE-1 cells 50 μM 24 h Inhibits the function of the Dynein-2 complex, leading to a significant decrease in the percentage of ciliated cells and cilia length ACS Chem Biol. 2024 Aug 16;19(8):1733-1742.
Mouse splenic B lymphocytes 50 μM 30 min To investigate the effect of Ciliobrevin D on CD154-induced CD40 internalization. Results showed that Ciliobrevin D treatment significantly reduced CD154-induced CD40 internalization in wild-type B lymphocytes but had no significant effect in JLP-deficient B lymphocytes. J Biol Chem. 2015 Feb 27;290(9):5256-66.

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.73mL

2.55mL

1.27mL

25.47mL

5.09mL

2.55mL

 

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