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Chemical Structure| 106-22-9 Chemical Structure| 106-22-9

Structure of Citronellol
CAS No.: 106-22-9

Chemical Structure| 106-22-9

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Citronellol, a constituent of rose and geranium oils, is used in perfumes and insect repellents.

Synonyms: (±)-β-Citronellol; Dihydrogeraniol; (±)-Citronellol

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Product Citations

Product Citations

Fryer, Emily ; Guha, Sujay ; Rogel-Hernandez, Lucero E ; Logan-Garbisch, Theresa ; Farah, Hodan ; Rezaei, Ehsan , et al.

Abstract: Throughout history, humans have relied on plants as a source of medication, flavoring, and food. Plants synthesize large chemical libraries and release many of these compounds into the rhizosphere and atmosphere where they affect animal and microbe behavior. To survive, nematodes must have evolved the sensory capacity to distinguish plant-made small molecules (SMs) that are harmful and must be avoided from those that are beneficial and should be sought. This ability to classify chemical cues as a function of their value is fundamental to olfaction, and represents a capacity shared by many animals, including humans. Here, we present an efficient platform based on multi-well plates, liquid handling instrumentation, low-cost optical scanners, and bespoke software that can efficiently determine the chemotaxis valence of single SMs in the model nematode, Caenorhabditis elegans. Using this integrated hardware-wetware-software platform, we screened 90 plant SMs and identified 37 that attracted or repelled wild-type animals, but had no effect on mutants defective in chemosensory transduction. Genetic dissection indicates that for at least 10 of these SMs, response valence emerges from the integration of opposing signals, arguing that olfactory valence is often determined by integrating chemosensory signals over multiple lines of information. This study establishes that C. elegans is an effective discovery engine for determining chemotaxis valence and for identifying natural products detected by the chemosensory nervous system.

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Product Details of Citronellol

CAS No. :106-22-9
Formula : C10H20O
M.W : 156.27
SMILES Code : CC(CCC=C(C)C)CCO
Synonyms :
(±)-β-Citronellol; Dihydrogeraniol; (±)-Citronellol
MDL No. :MFCD00002935
InChI Key :QMVPMAAFGQKVCJ-UHFFFAOYSA-N
Pubchem ID :8842

Safety of Citronellol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H317-H319
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Egg albumin protein 50 to 6400 µg/mL 20 min (15 min at 37°C + 5 min at 70°C) Evaluate the inhibitory effect of β-Citronellol on egg albumin protein denaturation, with maximum inhibition (50.23%) at 6400 µg/mL. Inflammopharmacology. 2024 Dec;32(6):3761-3784
Bovine Serum Albumin (BSA) 50 to 6400 µg/mL 50 min (20 min at 37°C + 30 min at 57°C) Assess the inhibitory effect of β-Citronellol on BSA protein denaturation, with maximum inhibition (70.20%) at 6400 µg/mL. Inflammopharmacology. 2024 Dec;32(6):3761-3784
Human Red Blood Cells (HRBCs) 50 to 6400 µg/mL 30 min Evaluate the protective effect of β-Citronellol on HRBCs membrane stabilization, with maximum effect observed at 6400 µg/mL (60.79% protection). Inflammopharmacology. 2024 Dec;32(6):3761-3784
BV2 cells 50 µg/mL 5 h To investigate the effect of Citronellol on the expression and phosphorylation of RIPK1, eIF4E, PI3K, Akt, and mTOR in BV2 cells. Results showed that Citronellol increased p-RIPK1, p-eIF4E, and p-PI3K levels. Cell Commun Signal. 2024 Sep 2;22(1):427

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Sprague-Dawley rats Histamine and Formaldehyde-induced inflammation models Oral 25, 50, and 100 mg/kg Single dose (Histamine model) or 3 days (Formaldehyde model) Evaluate the anti-inflammatory effect of β-Citronellol. Results showed 53.21% inhibition at 100 mg/kg in the Histamine model and 55.55% inhibition at 100 mg/kg in the Formaldehyde model. Inflammopharmacology. 2024 Dec;32(6):3761-3784

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.40mL

1.28mL

0.64mL

32.00mL

6.40mL

3.20mL

63.99mL

12.80mL

6.40mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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