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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1279680-68-0 Chemical Structure| 1279680-68-0

Structure of CL2A-SN-38
CAS No.: 1279680-68-0

Chemical Structure| 1279680-68-0

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CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types.

4.5 *For Research Use Only !

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Product Details of CL2A-SN-38

CAS No. :1279680-68-0
Formula : C73H97N11O22
M.W : 1480.61
SMILES Code : O=C(C=C1)N(CC2CCC(C(NCC3=CN(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(COCC(N[C@H](C(NC4=CC=C(COC(O[C@]5(CC)C(OCC6=C5C=C7N(CC8=C(CC)C9=CC(O)=CC=C9N=C87)C6=O)=O)=O)C=C4)=O)CCCCN)=O)=O)N=N3)=O)CC2)C1=O
MDL No. :MFCD32701926
InChI Key :CMVRBCDBISKHME-URBSQPMJSA-N
Pubchem ID :89983570

Safety of CL2A-SN-38

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P501-P270-P264-P301+P310+P330-P405
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
CL2A-SN-38 is an agent-linker conjugate comprising the potent DNA Topoisomerase I inhibitor SN-38 and the linker CL2A, designed for the formation of antibody-drug conjugates (ADCs). CL2A-SN-38 demonstrates substantial and selective antitumor efficacy across various human solid tumor types. Utilizing a hydrolyzable linker, CL2A-SN-38 facilitates the delivery of active agents into tumor cells and the tumor microenvironment, thereby inducing bystander effects[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.68mL

0.14mL

0.07mL

3.38mL

0.68mL

0.34mL

6.75mL

1.35mL

0.68mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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