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Chemical Structure| 73439-19-7 Chemical Structure| 73439-19-7

Structure of COH-SR4
CAS No.: 73439-19-7

Chemical Structure| 73439-19-7

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COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes.

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Product Details of COH-SR4

CAS No. :73439-19-7
Formula : C13H8Cl4N2O
M.W : 350.03
SMILES Code : O=C(NC1=CC(Cl)=CC(Cl)=C1)NC2=CC(Cl)=CC(Cl)=C2
MDL No. :MFCD01566238
InChI Key :VKVJIWVUYNTBEZ-UHFFFAOYSA-N
Pubchem ID :595311

Safety of COH-SR4

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of COH-SR4

epigenetics
PI3K-AKT

Isoform Comparison

Biological Activity

Description
COH-SR4 activates AMPK and exhibits strong anti-proliferative effects against leukemia, melanoma, breast, and lung cancers. It hinders adipocyte differentiation by activating AMPK. COH-SR4 is a valuable tool for studying obesity and associated metabolic disorders[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.28mL

2.86mL

1.43mL

28.57mL

5.71mL

2.86mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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