Home Cart Sign in  
Chemical Structure| 53947-92-5 Chemical Structure| 53947-92-5

Structure of Corylin
CAS No.: 53947-92-5

Chemical Structure| 53947-92-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Corylin is an orally active flavonoid with anti-inflammatory and osteogenic properties, inhibiting IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also exhibits anticancer, anti-atherosclerotic activities, and improves hyperlipidemia and insulin resistance by inducing adipocyte browning and lipolysis through SIRT1 or β3-AR dependent pathways.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Corylin

CAS No. :53947-92-5
Formula : C20H16O4
M.W : 320.34
SMILES Code : O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14
MDL No. :N/A

Safety of Corylin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Huh7 cells 30 μM 72 h Corylin significantly inhibited the proliferation of Huh7 cells Cell Death Dis. 2018 May 1;9(5):543
HepG2 cells 10 μM 72 h Corylin significantly inhibited the proliferation of HepG2 cells Cell Death Dis. 2018 May 1;9(5):543
Vascular smooth muscle cells (VSMCs) 20 µM 24 h Corylin inhibited PDGF-BB-induced VSMC proliferation and migration through regulating the mTOR/Drp1 signaling cascade. Antioxidants (Basel). 2020 Mar 25;9(4):275
HepG2 cells 3, 30, 300 μM 48 h Inhibited HepG2 cell proliferation, IC50 of 10 μM Int J Mol Sci. 2018 Jan 27;19(2):380
Huh7 cells 3, 30, 300 μM 48 h Inhibited Huh7 cell proliferation, IC50 of 30 μM Int J Mol Sci. 2018 Jan 27;19(2):380
B16F10 melanoma cells 1-25 μM 48 h To evaluate the inhibitory effect of Corylin on melanin synthesis. Results showed that Corylin reduced melanin production in a concentration-dependent manner, with 5 and 25 μM Corylin inhibiting melanin production by 48.2% and 77.9%, respectively. Additionally, Corylin inhibited intracellular tyrosinase activity, with inhibition rates of 11.2% and 67.7% at 5 and 25 μM, respectively. Nat Prod Bioprospect. 2025 Apr 27;15(1):27
Raw264.7 macrophages 20 μM 24 h Corylin reduced LPS-induced inflammatory responses in Raw264.7 macrophages through the SIRT1/NF-κB pathway. Front Pharmacol. 2023 May 17;14:1153810
NIH/3T3 fibroblasts 20 μM 24 h Corylin promoted migration, proliferation, and scratch healing of NIH/3T3 fibroblasts through the PI3K/AKT pathway. Front Pharmacol. 2023 May 17;14:1153810
HBEC3-KT cells 10–50 μM 24 h To evaluate the effect of Corylin on LPS-induced IL-6 production in HBEC3-KT cells. Results showed that Corylin significantly suppressed the production of IL-6 by LPS-induced HBEC3-KT cells in a concentration-dependent manner. Pharmaceuticals (Basel). 2021 Oct 14;14(10):1046
Human primary hepatocytes 3 µg/ml 4 h Corylin significantly reduced the levels of mSREBPs and their target gene expression. Theranostics. 2019 Aug 12;9(20):5769-5783
HL-7702 hepatocytes 3 µg/ml 4 h Corylin impaired the levels of mSREBP-1 and mSREBP-2 and significantly reduced the expression of their target genes. Theranostics. 2019 Aug 12;9(20):5769-5783
Human umbilical vein endothelial cells (HUVECs) 15 μM Corylin alleviates cellular senescence by suppressing the mTOR pathway, enhancing cell proliferation. Nat Commun. 2022 Mar 9;13(1):1238

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice High-fat diet-induced obese mice Gastric irrigation 15 or 30 mg/kg/day Once daily for 6 weeks To study the effect of corylin on lipid metabolism in obese mice, results showed that corylin significantly reduced body weight, serum TC, TG, and LDL-c levels, and increased HDL-c levels. Theranostics. 2019 Aug 12;9(20):5769-5783
Nude mice Huh7 xenograft model Intraperitoneal injection 20 mg/kg 3 times per week for 24 days Corylin significantly inhibited the growth of Huh7 xenograft tumors and enhanced the antitumor effects of the chemotherapeutic drug etoposide (VP16) Cell Death Dis. 2018 May 1;9(5):543
ApoE-deficient mice High-cholesterol diet-induced atherosclerosis model Oral 50 mg/kg Once daily for 15 weeks Corylin treatment significantly attenuated atherosclerotic lesions, ROS production, VCAM-1 expression, monocyte adhesion and VSMC proliferation in ApoE-deficient mice. Antioxidants (Basel). 2020 Mar 25;9(4):275
Nude mice Huh7 xenograft model Intraperitoneal injection 60 mg/kg Three times per week for 35 days Significantly inhibited tumor growth, reducing tumor volume by 87% Int J Mol Sci. 2018 Jan 27;19(2):380
C57BL/6 mice LPS-induced acute lung injury model Intraperitoneal injection 10 mg/kg or 20 mg/kg Single dose, lasting 4 hours To evaluate the protective effect of Corylin on LPS-induced acute lung injury in mice. Results showed that Corylin significantly reduced inflammatory cell infiltration in lung tissue, decreased levels of IL-6 and TNF-α in BALF and serum, and inhibited the phosphorylation of MAPKs and STAT3 in lung tissue. Pharmaceuticals (Basel). 2021 Oct 14;14(10):1046
C57BL/6J mice High-fat diet-induced obese mice Gastric irrigation 15 or 30 mg/kg Once daily for 6 weeks Corylin significantly reduced body weight gain, serum TC, TG, and LDL-c levels, and improved hepatic steatosis. Theranostics. 2019 Aug 12;9(20):5769-5783
C57BL/6J mice High-fat diet (HFD)-induced obesity model Oral 0.1% (w/w) corylin Continuous feeding until the end of the experiment Corylin significantly extended the lifespan of mice on a high-fat diet, improving metabolic and physical functions. Nat Commun. 2022 Mar 9;13(1):1238

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.12mL

0.62mL

0.31mL

15.61mL

3.12mL

1.56mL

31.22mL

6.24mL

3.12mL

References

 

Historical Records

Categories