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Chemical Structure| 500-05-0 Chemical Structure| 500-05-0
Chemical Structure| 500-05-0

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Product Details of Coumalic acid

CAS No. :500-05-0
Formula : C6H4O4
M.W : 140.09
SMILES Code : O=C1C=CC(C(O)=O)=CO1
MDL No. :MFCD00006644
InChI Key :ORGPJDKNYMVLFL-UHFFFAOYSA-N
Pubchem ID :68141

Safety of Coumalic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Coumalic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 500-05-0 ]

[ 500-05-0 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 500-05-0 ]
  • [ 6746-94-7 ]
  • [ 1798-82-9 ]
YieldReaction ConditionsOperation in experiment
42% In diethylene glycol dimethyl ether; for 36h;Reflux; Example 8. 4-(2-Guanidinothiazol-4-yl)phenyl 4-cyclopropylbenzoate (13f) (a) 4-Cyclopropylbenzoic acid.; Coulmalic acid (2.63 g, 18.74 mmol) and ethynylcyclopropane (1.24 g, 18.74 mmol) were combined in diglyme and brought to reflux for 36h. The reaction was then cooled and the solvent was removed under reduced pressure. The resultant slurry was recyrstallized in EtOH to yield 1.26 g (42%). 1HNMR (DMSO): delta 7.81 (d, J=8.4 Hz, 2H), 7.16 (d, J=8.4 Hz, 2H), 1.97 (sept, J=5.1 Hz, IH), 1.01 (m, 2H), 0.74 (m, 2H). 13CNMR (DMSO): delta 167.24, 149.51, 129.32, 127.65, 125.19, 15.25, 10.37.
  • 3
  • [ 500-05-0 ]
  • [ 768-60-5 ]
  • [ 725-14-4 ]
YieldReaction ConditionsOperation in experiment
44% In diethylene glycol dimethyl ether; for 36h;Reflux; (a) 4'-Methoxybiphenyl-4-carboxylic acid (7b).; Method A.Coumalic acid (1.06 g, 7.56 mmol) and 4-ethylnyl anisole were dissolved in diglyme and brought to reflux for 36h. The reaction was then allowed to cool and the solvent was removed under reduced pressure. The resultant slurry was then recrystallized from ethanol to yield 754 mg (44%) of a light tan solid.
 

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