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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 6199-67-3 Chemical Structure| 6199-67-3

Structure of Cucurbitacin B
CAS No.: 6199-67-3

Chemical Structure| 6199-67-3

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Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and could repress cancer cell progression.

Synonyms: Cuc B; NSC 144154; NSC 49451

4.5 *For Research Use Only !

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Product Details of Cucurbitacin B

CAS No. :6199-67-3
Formula : C32H46O8
M.W : 558.70
SMILES Code : O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C([C@@H](O)C[C@@]4([H])[C@]3(C)C2=O)=O
Synonyms :
Cuc B; NSC 144154; NSC 49451
MDL No. :MFCD07778083
InChI Key :IXQKXEUSCPEQRD-DKRGWESNSA-N
Pubchem ID :5281316

Safety of Cucurbitacin B

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H300
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of Cucurbitacin B

cytoskeleton

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
CRMM2 0.15 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
A549-GR cells 15 nM 48 h Inhibited EMT, decreased EGFR expression and ROS production Chin Med. 2022 Feb 19;17(1):24
A549 cells 5, 10, 15 nM 48 h Inhibited TGF-β1-induced EMT, reversed cell morphology changes, increased E-cadherin expression, decreased N-cadherin and Vimentin expression Chin Med. 2022 Feb 19;17(1):24
CRMM1 0.24 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
CM-AS16 0.08 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
CM2005.1 0.38 μM 72 h Inhibited cell proliferation Acta Pharm Sin B. 2022 Oct;12(10):3861-3876
Huh7 cells 4.1 μM 24 h To evaluate the inhibitory effect of CuB on Huh7 cell proliferation, results showed CuB significantly inhibited cell proliferation ACS Cent Sci. 2022 Aug 24;8(8):1102-1115

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c nude mice Human lung cancer (A549) xenograft model Intravenous injection 472 nM CuB Every other day for 14 days Evaluate the anticancer effects of CDNVs in vivo, results showed CDNVs significantly inhibited tumor growth without obvious toxicity. Int J Nanomedicine. 2022 Aug 10;17:3583-3599
C57BL/6J mice B16-F10 lung cancer metastasis model Intratracheal administration 0.25 mg/kg, 0.5 mg/kg Once daily for 14 days Inhibited lung cancer metastasis Chin Med. 2022 Feb 19;17(1):24
BALB/c mice H22 xenograft model Intraperitoneal injection 1 or 5 mg/kg Once daily for 14 days To evaluate the anti-HCC effect of CuB in vivo, results showed CuB significantly inhibited tumor growth and promoted immune cell infiltration ACS Cent Sci. 2022 Aug 24;8(8):1102-1115
NCG mice CRMM2 xenograft model Intragastric 1 mg/kg Five times per week for five weeks Significantly inhibited tumor progression without obvious side effects Acta Pharm Sin B. 2022 Oct;12(10):3861-3876

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02858388 Otitis Media With Effusion Phase 3 Completed - Italy ... More >> San Gennaro Hospital Naples, Italy, 80136 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.79mL

0.36mL

0.18mL

8.95mL

1.79mL

0.89mL

17.90mL

3.58mL

1.79mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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