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Chemical Structure| 18444-66-1 Chemical Structure| 18444-66-1

Structure of Cucurbitacin E
CAS No.: 18444-66-1

Chemical Structure| 18444-66-1

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Cucurbitacin E is a widely available plant-derived natural product, making it a useful tool to study actin dynamics in cells and actin-based processes such as cytokinesis.

Synonyms: α-Elaterin; α-Elaterine; NSC 521775

4.5 *For Research Use Only !

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Product Details of Cucurbitacin E

CAS No. :18444-66-1
Formula : C32H44O8
M.W : 556.69
SMILES Code : O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C(C(O)=C[C@@]4([H])[C@]3(C)C2=O)=O
Synonyms :
α-Elaterin; α-Elaterine; NSC 521775
MDL No. :MFCD00135936
InChI Key :NDYMQXYDSVBNLL-MUYMLXPFSA-N
Pubchem ID :5281319

Safety of Cucurbitacin E

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H300
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of Cucurbitacin E

Hedgehog

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
human chondrocytes 1, 5, 10 nM 24 h Inhibited the expression of inflammatory factors IL-1β and COX-2 induced by IL-1β, alleviated extracellular matrix degradation J Transl Med. 2023 Dec 4;21(1):880
A375 human melanoma cells 0, 1, 2, 4, 8 μM 24-48 h Inhibited A375 cell proliferation and induced apoptosis Chin Med. 2022 Feb 22;17(1):28
MRC-5 and HS68 cells 0, 1.25, 2.5, 5 µM 24 h To assess the effect of Cucurbitacin E on normal cells, results showed minimal impact on MRC-5 and HS68 cell proliferation. Int J Mol Sci. 2013 Aug 20;14(8):17147-56
SAS cells 0, 1.25, 2.5, 5 µM 24 to 72 h To evaluate the inhibitory effect of Cucurbitacin E on SAS cell proliferation, results showed that Cucurbitacin E inhibited SAS cell proliferation in a dose-dependent manner. Int J Mol Sci. 2013 Aug 20;14(8):17147-56
HUVEC cells 0, 10, 20, 40 nM 6 h To evaluate the effect of CuE on tube formation in HUVEC cells, results showed that CuE significantly inhibited tube formation. Molecules. 2020 Jan 28;25(3):560
Huh7 cells 0, 10, 20, 40 nM 24 or 48 h To evaluate the anti-proliferative effect of CuE on Huh7 cells, results showed that CuE significantly inhibited cell proliferation in a concentration- and time-dependent manner. Molecules. 2020 Jan 28;25(3):560
AMC-HN-8 cells 0.05, 0.1, 0.2 μM 24 h To evaluate the effect of Cucurbitacin E on mitochondrial membrane potential, results showed that Cucurbitacin E significantly decreased mitochondrial membrane potential. Am J Cancer Res. 2024 Aug 25;14(8):3905-3921
TU686 cells 0.05, 0.1, 0.2 μM 24 h To evaluate the effect of Cucurbitacin E on mitochondrial membrane potential, results showed that Cucurbitacin E significantly decreased mitochondrial membrane potential. Am J Cancer Res. 2024 Aug 25;14(8):3905-3921
AMC-HN-8 cells 0.05, 0.1, 0.2, 0.4 μM 24, 48, 72 h To evaluate the effect of Cucurbitacin E on the viability of LSCC cells, results showed that Cucurbitacin E significantly reduced the viability of LSCC cells in a concentration- and time-dependent manner. Am J Cancer Res. 2024 Aug 25;14(8):3905-3921
TU686 cells 0.05, 0.1, 0.2, 0.4 μM 24, 48, 72 h To evaluate the effect of Cucurbitacin E on the viability of LSCC cells, results showed that Cucurbitacin E significantly reduced the viability of LSCC cells in a concentration- and time-dependent manner. Am J Cancer Res. 2024 Aug 25;14(8):3905-3921
Human primary colorectal cancer cell lines (CP1-CP5) 2.5-7.5 μM 24 h To investigate the inhibitory effect of Cucurbitacin E on the proliferation of colorectal cancer cells and its ability to induce G2/M phase cell cycle arrest. Results showed that Cucurbitacin E inhibited cell proliferation in a dose-dependent manner and induced G2/M phase cell cycle arrest. Cell Death Dis. 2014 Apr 24;5(4):e1198
Human brain malignant glioma GBM 8401 cells 0, 2.5, 5, 10 μM 24 h To evaluate the inhibitory effect of Cucurbitacin E on the proliferation of GBM 8401 cells. Results showed that Cucurbitacin E inhibited the proliferation of GBM 8401 cells in a dose-dependent manner and induced G2/M phase cell cycle arrest. Cell Death Dis. 2014 Feb 27;5(2):e1087

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice Medial meniscal instability-induced osteoarthritis model Intra-articular injection 0.5 mg/kg Twice a week for 3 months Evaluated the effect of Cucurbitacin E on knee joint degeneration, results showed Cucurbitacin E had a protective effect on knee cartilage in the osteoarthritis model J Transl Med. 2023 Dec 4;21(1):880
BALB/c-nu nude mice ACC xenograft model Intraperitoneal injection 10, 20 mg/kg Once daily for 3 weeks To evaluate the inhibitory effect of Cucurbitacin E on ACC xenograft tumors, results showed that Cucurbitacin E dose-dependently inhibited tumor growth, and its combination with mitotane almost completely eliminated the tumors. J Transl Med. 2022 Oct 2;20(1):444
BALB/c nu/nu athymic nude mice Subcutaneous melanoma xenograft model Intraperitoneal injection 5 mg/kg Once every four days for 3 weeks Inhibited melanoma growth Chin Med. 2022 Feb 22;17(1):28
C57BL/6j mice DSS-induced colitis model Oral gavage 10 mg/kg Once daily for 14 days Alleviated DSS-induced colitis symptoms, improved intestinal barrier function and inflammatory response, modulated gut microbiota composition J Inflamm Res. 2024 May 6;17:2745-2756
BALB/c nude mice TU686 cell xenograft model Intraperitoneal injection 5 or 10 mg/kg Administered every other day for three weeks To evaluate the anti-tumor activity of Cucurbitacin E in vivo, results showed that Cucurbitacin E significantly inhibited tumor growth and induced tumor cell apoptosis. Am J Cancer Res. 2024 Aug 25;14(8):3905-3921

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02858388 Otitis Media With Effusion Phase 3 Completed - Italy ... More >> San Gennaro Hospital Naples, Italy, 80136 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

8.98mL

1.80mL

0.90mL

17.96mL

3.59mL

1.80mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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