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Chemical Structure| 13657-68-6 Chemical Structure| 13657-68-6

Structure of Curdione
CAS No.: 13657-68-6

Chemical Structure| 13657-68-6

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Curdione, one of the major sesquiterpene compounds from Rhizoma Curcumae, has been shown to exhibit multiple bioactive properties.

Synonyms: (+)-Curdione

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Product Details of Curdione

CAS No. :13657-68-6
Formula : C15H24O2
M.W : 236.35
SMILES Code : O=C1C[C@@H](C(C)C)C(C/C(C)=C/CC[C@@H]1C)=O
Synonyms :
(+)-Curdione
MDL No. :MFCD01725514

Safety of Curdione

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
SW480 cells 12.5 μM, 25 μM, 50 μM 48 h To evaluate the effect of Curdione on SW480 cells. The results showed that Curdione also induced ferroptosis in SW480 cells. Chin Med. 2023 Sep 21;18(1):122
CT26 cells 12.5 μM, 25 μM, 50 μM 48 h To evaluate the inhibitory effect of Curdione on the growth of CRC cells. The results showed that Curdione decreased the viability of CT26 cells in a dose-dependent manner, with the lowest cell survival at 50 μM. Chin Med. 2023 Sep 21;18(1):122
TC-1 cells 100 mg/mL 24 h Inhibited the mRNA expression of HPV E6 and E7, and suppressed the phosphorylation levels of AKT and ERK1/2 proteins. Front Immunol. 2025 Jan 22;16:1503355
Dendritic cells (DC 2.4) 100 mg/mL 24 h Upregulated the mRNA expression levels of IL-12 and IL-23, effectively regulating T cell activation. Front Immunol. 2025 Jan 22;16:1503355
Macrophages (Raw 264.7) 100 mg/mL 24 h Inhibited the mRNA expression of IL-6, IL-1β, and TLR4, while promoting the expression of IL-10 and TGF-β, and inhibited the phosphorylation and nuclear translocation of NF-κB p65 protein. Front Immunol. 2025 Jan 22;16:1503355

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice Bleomycin (BLM)-induced pulmonary fibrosis model Intraperitoneal injection 100 mg/kg Every 2 days for 21 days To evaluate the therapeutic effect of Curdione on BLM-induced pulmonary fibrosis. Results showed that Curdione significantly alleviated BLM-induced lung injury and fibrosis, and reduced fibroblast to myofibroblast differentiation. Respir Res. 2020 Feb 19;21(1):58
C57BL/6 mice MCD feed-induced hepatic fibrosis model Gavage 50 mg/kg Once daily for 6 weeks Curdione significantly alleviated MCD-induced hepatic fibrosis in mice by modulating the TGF-β1/Smad signaling pathway. Front Cell Dev Biol. 2021 Nov 10;9:763864
Sprague Dawley rats Middle cerebral artery occlusion (MCAO) model Intragastric administration 100 mg/kg Once daily for 7 days before surgery and 14 days after the start of reperfusion Curdione significantly reduced the infarct size and neurological deficits, promoted cognitive function recovery, and recovered neuronal morphologic damages in MCAO rats. It also blocked the increase of MDA content and elevated the activities of SOD, CAT, and GSH-PX. Moreover, curdione attenuated the expression of Cyt-C, c-caspase-3, and c-caspase-9, increased the Bcl-2/Bax ratio, and hence decreased cellular apoptosis. Neuropsychiatr Dis Treat. 2017 Jun 30;13:1733-1740
BALB/c nude mice CT26 subcutaneous transplantation tumor model Subcutaneous injection 50 mg/kg, 100 mg/kg, 200 mg/kg Daily administration for 22 days To evaluate the inhibitory effect of Curdione on tumor growth in CRC mice. The results showed that Curdione significantly inhibited tumor growth, with the therapeutic effect of the high-dose group being close to that of oxaliplatin. Chin Med. 2023 Sep 21;18(1):122
C57BL/6 mice LPS/TC-1 cervical orthotopic injection model Vaginal lavage 100 mg/mL Once every two days, for a total of seven treatments Inhibited the secretion of IL-6 and IL-1β, blocked the STAT3-CD274 axis-mediated immune escape, promoted the infiltration and recognition of CD3+CD8+ T cells, and effectively cleared HPV-infected cervical epithelial cells. Front Immunol. 2025 Jan 22;16:1503355

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.23mL

0.85mL

0.42mL

21.16mL

4.23mL

2.12mL

42.31mL

8.46mL

4.23mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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