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Chemical Structure| 152-53-4 Chemical Structure| 152-53-4

Structure of Cycloguanil HCl
CAS No.: 152-53-4

Chemical Structure| 152-53-4

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Cycloguanil HCl is HCl form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor.

Synonyms: Cycloguanil (hydrochloride); Cycloguanil hydrochloride; NSC 3074

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Product Details of Cycloguanil HCl

CAS No. :152-53-4
Formula : C11H15Cl2N5
M.W : 288.18
SMILES Code : NC1=NC(N)=NC(C)(C)N1C2=CC=C(Cl)C=C2.[H]Cl
Synonyms :
Cycloguanil (hydrochloride); Cycloguanil hydrochloride; NSC 3074
MDL No. :MFCD00035308
InChI Key :MOUAPRKJJUXEIE-UHFFFAOYSA-N
Pubchem ID :9048

Safety of Cycloguanil HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Ugandan Plasmodium falciparum isolates 1200 nM 72 h Evaluate inhibitory activity of Cycloguanil against Ugandan field isolates, showing high-level resistance J Infect Dis. 2022 Feb 15;225(4):696-704
Plasmodium falciparum Dd2 1400 nM 72 h Evaluate inhibitory activity of Cycloguanil against triple-mutant PfDHFR J Infect Dis. 2022 Feb 15;225(4):696-704
Plasmodium falciparum 3D7 4.8 nM 72 h Evaluate inhibitory activity of Cycloguanil against WT PfDHFR J Infect Dis. 2022 Feb 15;225(4):696-704

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.47mL

0.69mL

0.35mL

17.35mL

3.47mL

1.74mL

34.70mL

6.94mL

3.47mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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