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Chemical Structure| 921625-62-9 Chemical Structure| 921625-62-9

Structure of Cysteine Protease inhibitor
CAS No.: 921625-62-9

Chemical Structure| 921625-62-9

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Cysteine protease inhibitor is an inhibitor of cysteine protease.

4.5 *For Research Use Only !

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Product Details of Cysteine Protease inhibitor

CAS No. :921625-62-9
Formula : C18H14N4O
M.W : 302.33
SMILES Code : N#CC1=NC=CC(OC2=CC=CC(C3=CC=C(C=C3)CN)=C2)=N1
MDL No. :MFCD00130887

Safety of Cysteine Protease inhibitor

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Cysteine Protease inhibitor

pyroptosis

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00157508 Type 2 Diabetes ... More >> Early Nephropathy Less << Phase 2 Terminated - Italy ... More >> Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Less <<
NCT00166166 Hyperlipidemia Phase 2 Terminated(Limited clinical st... More >>aff) Less << - United States, Georgia ... More >> Emory University School of Medicine Atlanta, Georgia, United States, 30322 Less <<
NCT00166166 - Terminated(Limited clinical st... More >>aff) Less << - -
NCT00331786 Colorectal Cancer Phase 1 Completed - United States, New York ... More >> Stony Brook University Cancer Center Stony Brook, New York, United States, 11794-8174 Less <<
NCT00399256 Chronic Kidney Failure Not Applicable Terminated - Germany ... More >> Robert-Bosch-Hospital Stuttgart, Germany, D-70376 Less <<
NCT00170911 Osteoporosis Phase 2 Completed - -
NCT02113150 Coronary Artery Disease Phase 4 Completed - Turkey ... More >> Aslı Demir Ankara, Turkey, 06100 Turkey Yuksek Ihtisas Education and Research Hospital Ankara, Turkey, 06550 Less <<
NCT02189122 Healthy Not Applicable Completed - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less <<
NCT02341300 Iron-deficiency Anemia Not Applicable Recruiting November 2020 United States, New York ... More >> New York Prebyterian Hospital Weill Cornell Recruiting New York, New York, United States, 10021 Contact: Shari Gelber, MD    212-746-3182    shg7001@med.cornell.edu    Contact: Chelsea Clinton, MD    734-223-6103    cmk9008@nyp.org    Sub-Investigator: Chelsea Clinton, MD          Principal Investigator: Shari Gelber, MD          Sub-Investigator: Melissa Yoffee, RD Less <<
NCT03738878 Hypertension Phase 4 Recruiting December 31, 2020 United States, Tennessee ... More >> Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37205 Contact: Nancy J Brown, MD    615-343-8701       Contact: Dustin Mayfield, RN    615-343-8701 Less <<
NCT01256775 Intermittent Claudication Phase 2 Completed - Italy ... More >> Ospedale di Perugia Perugia, Italy, 06126 Less <<
NCT00868855 Coronary Artery Disease Phase 1 Terminated(poor enrollment) - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less <<
NCT00223704 - Completed - -
NCT02189122 - Completed - -
NCT00965120 Ischaemic Heart Diseases Not Applicable Completed - United Kingdom ... More >> University of Edinburgh, 49 Little France Crescent Edinburgh, United Kingdom, EH16 4SB Less <<
NCT00685945 - Completed - -
NCT00517582 Angioneurotic Edema Phase 1 Terminated(This study was stop... More >>ped to allow initiation of a mult-center study) Less << - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37205 Less <<
NCT00685945 Obesity Not Applicable Completed - United States, Tennessee ... More >> Vanderbilt University Medical Center-GCRC Nashville, Tennessee, United States, 37232 Less <<
NCT03030703 Iron-deficiency ... More >> Iron Deficiency Anemia Less << Not Applicable Completed - United States, Kansas ... More >> Physical Activity and Nutrition Research Consortium Manhattan, Kansas, United States, 66502 Less <<
NCT00223704 Cardiopulmonary Bypass ... More >> Inflammation Fibrinolysis Surgery Less << Phase 2 Phase 3 Completed - United States, Tennessee ... More >> TN Valley Healthcare System Nashville, Tennessee, United States, 37212 Vanderbilt University Nashville, Tennessee, United States, 37232 Less <<
NCT01574248 ACE Inhibitor-associated Angio... More >>edema Less << Phase 4 Terminated(DSMC recommended di... More >>scontinuation for futility and feasibility) Less << - United States, California ... More >> University of California, San Diego San Diego, California, United States, 92093 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37235 Less <<
NCT01413542 Hypertension ... More >>Diabetes Type 2 Less << Not Applicable Completed - United States, Tennessee ... More >> Vanderbilt University- General Clinic Research Center Nashville, Tennessee, United States, 37232 Less <<
NCT00965393 Ischaemic Heart Diseases Not Applicable Completed - United Kingdom ... More >> University of Edinburgh, 49 Little France Crescent Edinburgh, United Kingdom, EH16 4SB Less <<
NCT01137942 - Unknown July 2010 Slovenia ... More >> Abakus Medico Recruiting Rogaska Slatina, Slovenia Contact: Bojan Tepes, MD. PhD    +386 (0) 3 819 14 11    abakus.medico@volja.net    Principal Investigator: Bojan Tepes, MD, Phd          Sub-Investigator: Miha Skvarc, MD Less <<
NCT00083356 Tooth, Impacted Phase 2 Completed - United States, Maryland ... More >> National Institute of Nursing Research (NINR) Bethesda, Maryland, United States, 20892 Less <<
NCT01574248 - Terminated(DSMC recommended di... More >>scontinuation for futility and feasibility) Less << - -
NCT00780377 Heart Transplantation Not Applicable Withdrawn(Unable to perform st... More >>udy due to unavailable drug, then unable to partner with cath lab) Less << - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less <<
NCT00780481 - Terminated(Lack of enrollment ... More >>due to strict inclusion/exclusion criteria. Bradykinin shortage) Less << - -
NCT00300066 - Completed - Denmark ... More >> Department of Nuclear Medicine, University Hospital Aarhus, Skejby Aarhus, Brendstrupgaardsvej 100, Denmark, 8200 Department of Clinical Physiology, University Hospital of Aarhus, Aalborg Aalborg, Hobrovej 18-22, Denmark, 9000 Less <<
NCT00462527 - Completed - Canada, Ontario ... More >> Department of Pediatric Emergency, Children's Hospital of Eastern Ontario Ottawa, Ontario, Canada, K1H 8L1 Less <<
NCT00467311 - Completed - Mexico ... More >> Ignacio Chávez National Institute of Cardiology Mexico City, DF, Mexico, 01480 Less <<
NCT01413542 - Completed - -
NCT00780481 Obesity Not Applicable Terminated(Lack of enrollment ... More >>due to strict inclusion/exclusion criteria. Bradykinin shortage) Less << - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less <<
NCT00504855 Pressure Ulcer Not Applicable Terminated(Staffing changes re... More >>sulted in the expiration of IRB approval (2/15/12), and recruitment halted (n=84). IRB approval is now current for retrospective analysis.) Less << March 2014 United States, Hawaii ... More >> Shriners Hospitals for Children - Honolulu Honolulu, Hawaii, United States, 96826 Less <<
NCT01114074 - Unknown April 2017 Netherlands ... More >> Maastricht University Maastricht, Limburg, Netherlands, 6229 ER Less <<
NCT00704743 Colles' Fracture Phase 3 Completed - Canada, British Columbia ... More >> Department of Emergency Medicine, St Paul's Hospital Vancouver, British Columbia, Canada, V1Y 1Z1 Less <<
NCT00823823 Displaced Forearm Fractures Not Applicable Completed - United States, Massachusetts ... More >> Childrens Hospital Boston Boston, Massachusetts, United States, 02125 Less <<
NCT00916539 Non-displaced Scaphoid Fractur... More >>es Less << Not Applicable Completed - United States, Massachusetts ... More >> Massachusettes General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT00823823 - Completed - -
NCT01221207 Diabetic Foot Ulcers Not Applicable Unknown October 2012 United States, Arizona ... More >> University of Arizona Recruiting Tucson, Arizona, United States Contact: David Armstrong, D    520-626-1349       United States, Texas Parkland Health & Hospital Systems Not yet recruiting Dallas, Texas, United States, 75235 Contact: Lawrence Lavery, DPM    214-645-0544    LLAVE1@mednet.swmed.edu    Contact: Cecilia Lara    214-645-2377    cecilia.lara@utsouthwestern.edu    UT Southwestern Medical Center at Dallas Not yet recruiting Dallas, Texas, United States, 75390 Contact: Lawrence Lavery, DPM    214-645-0544    LLAVE1@mednet.swmed.edu    Contact: Cecilia Lara    214-645-2377    cecilia.lara@utsouthwestern.edu    Scott & White Recruiting Temple, Texas, United States Contact: Douglas Murdoch, DPM    214-771-7604    DMurdoch@swmail.sw.org Less <<
NCT00780637 Heart Transplantation Not Applicable Withdrawn(Bradykinin Shortage,... More >> SCCOR expired prior to BK availability, lack of enrollment.) Less << - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less <<
NCT01238523 Tibial Shaft Fractures in Chil... More >>dren Less << Not Applicable Completed - United States, California ... More >> Los Angeles Orthopaedic Hospital Los Angeles, California, United States, 90007 Less <<
NCT01403766 - Unknown December 2012 United States, California ... More >> University of California, Los Angeles Not yet recruiting Los Angeles, California, United States, 90095 Contact: Eileen Tsai, M.D.    310-206-8415    etsai@mednet.ucla.edu    Principal Investigator: Eileen Tsai, M.D.          Sub-Investigator: John Nguyen, M.D. Less <<
NCT00561483 - Completed - United States, Ohio ... More >> Cleveland Clinic Cleveland, Ohio, United States, 44195 Less <<
NCT01652755 - Unknown May 2013 China, Zhejiang ... More >> Jinhua central hospital Recruiting Jinhua, Zhejiang, China, 321000 Contact: Hongying Ni, MM    86 ext 57982552629    nihongying2@163.com    Principal Investigator: Hongying Ni, MM Less <<
NCT01758835 Lateral Malleolus Fractures Not Applicable Completed - Finland ... More >> OYS, kirurgian klinkka, Oulu Oulu, Finland, 90100 Less <<
NCT01318746 - Completed - Germany ... More >> Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Erlangen, Germany, 91054 Less <<
NCT02047240 - Completed - Mexico ... More >> Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" Mexico City, DF, Mexico, 14000 Less <<
NCT01908309 Contrast Induced Acute Kidney ... More >>Injury Less << Early Phase 1 Completed - Italy ... More >> Misericordia Hospital, ASL 9 Grosseto, Italy, 58100 Less <<
NCT02066857 Radius; Fracture, Lower or Dis... More >>tal End Less << Not Applicable Completed - United States, Georgia ... More >> Emory Orthopaedics and Spine Center Atlanta, Georgia, United States, 30329 Less <<
NCT02095106 Pediatric Distal Radius Fractu... More >>res Less << Not Applicable Completed - United States, California ... More >> Orthopaedic Institute for Children Los Angeles, California, United States, 90007 Less <<
NCT02095106 - Completed - -
NCT02233179 Diabetic Foot Not Applicable Completed - United States, Arizona ... More >> University Medical Center Tucson, Arizona, United States, 85724 Less <<
NCT02066857 - Completed - -
NCT02334033 - Completed - Turkey ... More >> Ankara University School Of Medicine, Department of Cardiology Ankara, Turkey, 06230 Less <<
NCT02433002 - Active, not recruiting December 31, 2019 United Kingdom ... More >> Derby Hospitals NHS Foundation Trust (Royal Derby Hospital) Derby, Derbyshire, United Kingdom, DE22 3NE King's College Hospital NHS Foundation Trust London, Greater London, United Kingdom, SE5 NRS Salford Royal NHS Foundation Trust (Salford Royal Hospital) Salford, Greater Manchester, United Kingdom, M6 8HD East Kent Hospitals NHS Trust (Kent & Canterbury Hospital) Canterbury, Kent, United Kingdom, CT1 3NG University Hospitals of Leicester NHS Trust (Leicester General Hospital) Leicester, Leicestershire, United Kingdom, LE54PW University Hospital Birmingham NHS Trust (Queen Elizabeth Hospital Birmingham) Birmingham, West Midlands, United Kingdom, B15 2TH Less <<
NCT02614690 Fracture of Shaft of Radius an... More >>d/or Ulna Metaphyseal Fracture of Bone of Upper Limb Fracture of Upper Limb, Level Unspecified Less << Not Applicable Unknown January 2017 United States, Connecticut ... More >> Connecticut Children's Medical Center Recruiting Hartford, Connecticut, United States, 06016 Contact: Matt Solomito    860-284-0208    mailto:msolomito@ccmckids.org    Principal Investigator: Mark Lee, MD Less <<
NCT00916539 - Completed - -
NCT02822404 Kidney Diseases Not Applicable Active, not recruiting September 2020 France ... More >> CHU Toulouse Toulouse, France, 31059 Less <<
NCT02894164 - Completed - Sweden ... More >> Karolinska Institute Stockholm, Sweden, 171 77 Less <<
NCT02894983 Colles' Fracture ... More >> Distal Radius Fracture Less << Not Applicable Completed - Finland ... More >> Central Finland Central Hospital Jyväskylä, Finland Satakunta Central Hospital Pori, Finland Tampere Univeristy Hospital Tampere, Finland Less <<
NCT02276066 Sepsis Phase 4 Recruiting April 2020 United States, Florida ... More >> UF Health at Shands hospital Recruiting Gainesville, Florida, United States, 32610 Contact: Jennifer Lanz, MSN    352-273-5497    jennifer.lanz@surgery.ufl.edu    Contact: Ruth Davis, ASN    325-273-5497    ruth.davis@surgery.ufl.edu Less <<
NCT01474473 Foot Ulcer Di... More >>abetes Mellitus Diabetic Neuropathy Less << Not Applicable Completed - France ... More >> Pitié-Salpêtrière Hospital Paris, France, 75013 Less <<
NCT03297047 Salter-Harris Type I ... More >> Salter-Harris Type 2 Radius Fractures Forearm Fracture Less << Not Applicable Not yet recruiting June 30, 2019 -
NCT03468023 Radius Fracture Distal Not Applicable Recruiting October 20, 2019 Italy ... More >> Ospedale Civile Maggiore Borgo Trento Recruiting Verona, Italy, 37126 Contact: Giovanni Dib, MD    +39 349 121 4908    dib.giovanni@gmail.com    Contact: Matteo Cengarle, MD    +39 340 981 7025    matteo_29@hotmail.com Less <<
NCT03240471 Distal Radius Fracture Not Applicable Active, not recruiting December 2019 Netherlands ... More >> Rijnstate hospital Arnhem, Netherlands Ziekenhuis Gelderse Vallei Ede, Netherlands Radboudumc Nijmegen, Netherlands Less <<
NCT03486184 - Not yet recruiting April 30, 2020 -
NCT03610191 - Recruiting July 1, 2020 China, Shaanxi ... More >> Xijing Hospital Recruiting Xi'an, Shaanxi, China, 710032 Contact: Jing Zhao, M.D.    13892810471       Contact: Lihong Hou, M.D., Ph.D.    +862984775337 Less <<
NCT03170687 Acute Closed Fracture of Proxi... More >>mal Fifth Metatarsal (Zone II) Less << Not Applicable Completed - Thailand ... More >> Jatupon Kongtharvonskul Bangkok, Select..., Thailand, 10400 Less <<
NCT03751397 - Not yet recruiting December 2019 Switzerland ... More >> University of Basel Children's Hospital Not yet recruiting Basel, Switzerland, 4031 Contact: Tatjana Welzel, Dr. med    +41 (0)61 704 18 17    tatjana.welzel@ukbb.ch Less <<
NCT00080236 Liver Transplantation ... More >> Hepatitis Cholestasis Carcinoma, Hepatocellular Less << Phase 2 Completed - United States, Arizona ... More >> Mayo Clinic Scottsdale Phoenix, Arizona, United States, 85054 United States, California University of California Los Angeles Los Angeles, California, United States, 90095 University of California San Francisco San Francisco, California, United States, 94143 United States, Indiana Indiana University Medical Center Indianapolis, Indiana, United States, 46202 United States, Louisiana Tulane University Hospital and Clinic New Orleans, Louisiana, United States, 70112 United States, Minnesota Mayo Clinic Rochester Rochester, Minnesota, United States, 55905 United States, New York Mount Sinai School of Medicine New York City, New York, United States, 10029 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45267 United States, Texas Baylor Regional Transplant Institute, Baylor University Medical Center Dallas, Texas, United States, 75246 The University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229 Germany Oberarzt der Klinik für Allgemein-, Viszeral- und Transplantationschirurgie Charité-Virchow Berlin, Germany, D-13353 Klinik für Viszeral- und Transplantationschirurgie Medizinische Hochschule Hannover Hannover, Germany, D-30623 Abteilung für Transplantationschirurgie Johannes Gutenberg-Universität Mainz Mainz, Germany, 55101 Less <<
NCT00088140 Hepatitis C, Chronic Phase 2 Completed - United States, Arizona ... More >> Mayo Clinic Hospital Phoenix, Arizona, United States, 85054 United States, California Scripps Clinic La Jolla, California, United States, 92067 California Pacific Medical Center San Francisco, California, United States, 94115 University of California, San Francisco San Francisco, California, United States, 94143 United States, Florida University of Miami Miami, Florida, United States, 33136 United States, Indiana Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 United States, Massachusetts Beth Israel Deaconness Medical Center Boston, Massachusetts, United States, 02215 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, Minnesota The Mayo Clinic Rochester, Minnesota, United States, 55905 United States, New York Mt. Sinai School of Medicine New York City, New York, United States, 10029 United States, North Carolina University of North Carolina Chapel Hill, North Carolina, United States, 27599 Duke University Medical Center Durham, North Carolina, United States, 27715 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45267 Metrohealth Medical Center Cleveland, Ohio, United States, 44109 United States, Virginia Medical College of Virginia Richmond, Virginia, United States, 23298 Less <<
NCT02686762 Non-alcoholic Steatohepatitis ... More >> Fibrosis Liver Diseases Less << Phase 2 Active, not recruiting January 2019 -
NCT01653899 Diabetes Phase 1 Phase 2 Completed - Canada, Alberta ... More >> University of Alberta Edmonton, Alberta, Canada Less <<
NCT03617055 - Not yet recruiting July 1, 2020 -
NCT02960204 Cirrhosis Por... More >>tal Hypertension Non-alcoholic Steatohepatitis Less << Phase 2 Active, not recruiting April 2019 -
NCT03205345 Decompensated Cirrhosis Phase 2 Recruiting August 2019 -
NCT02798614 Colles' Fracture Not Applicable Completed - -
NCT02945241 Methicillin-resistant Staphylo... More >>coccus Aureus Sepsis Critical Illness Less << Phase 1 Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.08mL

6.62mL

3.31mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

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