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Structure of Cytisinicline
CAS No.: 485-35-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Cytisine is a naturally occuring alkaloid nAchR agonist with a short half-life of 4.8 hours.
Synonyms: Cytisine; Sophorine; Sophorin
4.5
*For Research Use Only !
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 485-35-8 |
Formula : | C11H14N2O |
M.W : | 190.24 |
SMILES Code : | O=C1/C=C\C=C2/N1C[C@@H]3CNC[C@H]2C3 |
Synonyms : |
Cytisine; Sophorine; Sophorin
|
MDL No. : | MFCD00136048 |
GHS Pictogram: |
![]() |
Signal Word: | Danger |
Hazard Statements: | H301-H311-H331 |
Precautionary Statements: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 |
Class: | 6.1 |
UN#: | 1544 |
Packing Group: | Ⅲ |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03654105 | Inflammation ... More >>Smoking Cessation Diet Modification Physical Activity Lung Cancer Less << | Phase 2 | Not yet recruiting | October 2020 | Italy ... More >> Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy, 20133 Less << |
NCT02797587 | HIV Infection ... More >> Alcohol Use Smoking Less << | Phase 2 Phase 3 | Recruiting | December 2020 | Russian Federation ... More >> First St. Petersburg Pavlov State Medical University Recruiting St. Petersburg, Russian Federation, 197022 Contact: Evgeny Krupitsky, MD,PhD,DMdSc +7-812-365-2217 kruenator@gmail.com Less << |
NCT03709823 | Smoking Cessation | Phase 2 | Recruiting | June 30, 2019 | United States, Arizona ... More >> Clinical Research Consortium Recruiting Tempe, Arizona, United States, 85283 Contact: Corey G Anderson, MD United States, California Los Angeles Clinical Trials Recruiting Burbank, California, United States, 91505 Contact: Nitchell Nides, PhD United States, Kentucky Central Kentucky Research Associates, LLC Recruiting Lexington, Kentucky, United States, 40509 Contact: Mark S Adams, MD United States, Missouri Center for Pharmaceutical Research, LLC Recruiting Kansas City, Missouri, United States, 64114 Contact: John E Ervin, MD United States, New York Rochester Clinical Research, Inc Recruiting Rochester, New York, United States, 14609 Contact: Matthew G Davis, MD United States, South Carolina Coastal Carolina Research Center, Inc Recruiting Mount Pleasant, South Carolina, United States, 29464 Contact: Cynthia Strout, MD United States, Tennessee Volunteer Research Group Recruiting Knoxville, Tennessee, United States, 37920 Contact: William B Smith, MD United States, Texas FutureSearch Trails of Dallas, LP Recruiting Dallas, Texas, United States, 57231 Contact: Michael Downing, MD Less << |
NCT02957786 | Smoking Cessation | Phase 3 | Recruiting | May 2019 | New Zealand ... More >> National Institute for Health Innovation, University of Auckland Recruiting Auckland, North Island, New Zealand, 1072 Contact: Natalie Walker, PhD 64 9 373 7999 n.walker@auckland.ac.nz Contact: Chris Bullen, PhD, MBChB 64 9 373 7999 c.bullen@auckland.ac.nz Principal Investigator: Natalie Walker, PhD Sub-Investigator: Chris Bullen, PhD;MBChB Sub-Investigator: Joanne Barnes, PhD Sub-Investigator: Barry Smith, PhD Sub-Investigator: Subhash Pokhrel, PhD Sub-Investigator: Varsha Parag, MSc (Hons) Less << |
NCT03268343 | Smoking Cessation | PHASE1 | COMPLETED | 2017-09-01 | Simbec Research Ltd, Merthyr T... More >>ydfil, CF11 9AB, United Kingdom Less << |
NCT02585024 | Smoking Cessation | PHASE1 | TERMINATED | 2025-03-19 | Soo Hee Jeong, Auckland, 1072,... More >> New Zealand Less << |
NCT03303911 | Smoking Cessation | PHASE1|PHASE2 | TERMINATED | 2018-10-05 | Simbec Research Ltd, Cardiff, ... More >>CF11 9AB, United Kingdom Less << |
NCT03509948 | Smoking Cessation | Phase 1 | Completed | - | United Kingdom ... More >> Simbec Research Ltd Cardiff, United Kingdom, CF11 9AB Less << |
NCT06435221 | Smoking Cessation|Vaping Cessa... More >>tion Less << | PHASE3 | ACTIVE_NOT_RECRUITING | 2025-12-31 | Alliance for Multispecialty Re... More >>search, LLC, Mobile, Alabama, 36608, United States|Alliance for Multispecialty Research, LLC, Tempe, Arizona, 85281, United States|Little Rock Allergy & Asthma Clinical Research Center, Little Rock, Arkansas, 72205, United States|Alliance for Multispecialty Research, LLC, Coral Gables, Florida, 33134, United States|Accel Research Sites Network - DeLand Clinical Research Unit, DeLand, Florida, 32720, United States|Alliance for Multispecialty Research, LLC, Fort Myers, Florida, 33912, United States|Jacksonville Center for Clinical Research, Jacksonville, Florida, 32216, United States|Precision Clinical Research, Sunrise, Florida, 33351, United States|Clinical Research Atlanta, Stockbridge, Georgia, 30281, United States|Alliance for Multispecialty Research, LLC, Oak Brook, Illinois, 60523, United States|MediSphere Medical Research Center, LLC, Evansville, Indiana, 47714, United States|Alliance for Multispecialty Research, LLC, Wichita, Kansas, 67207, United States|Alliance for Multispecialty Research, LLC, Lexington, Kentucky, 40509, United States|Alliance for Multispecialty Research, LLC, New Orleans, Louisiana, 70119, United States|Massachusetts General Hospital - Clinical Genetic Facility, Boston, Massachusetts, 02114, United States|Insight Research Institute, Flint, Michigan, 48507, United States|Alliance for Multispecialty Research, LLC, Kansas City, Missouri, 64114, United States|Alliance for Multispecialty Research, LLC, Las Vegas, Nevada, 89119, United States|Global Medical Institutes LLC; Princeton Medical Institute, Princeton, New Jersey, 08540, United States|Rochester Clinical Research, LLC, Rochester, New York, 14609, United States|Centricity Research Columbus Ohio Multispecialty, Columbus, Ohio, 43213, United States|Alliance for Multispecialty Research, LLC, Norman, Oklahoma, 73069, United States|Altoona Center for Clinical Research, Duncansville, Pennsylvania, 16635, United States|Coastal Carolina Research Center, North Charleston, South Carolina, 29405, United States|Alliance for Multispecialty Research, LLC, Knoxville, Tennessee, 37909, United States|Clinical Research Associates, Inc., Nashville, Tennessee, 37203, United States|Clinical Trials of Texas, LLC, San Antonio, Texas, 78229, United States|Health Research of Hampton Roads, Inc., Newport News, Virginia, 23606, United States|Alliance for Multispecialty Research, LLC, Norfolk, Virginia, 23502, United States Less << |
NCT05981768 | Smoking Cessation | PHASE1 | COMPLETED | 2023-09-21 | BlueClinical Phase I, Porto, 4... More >>250-449, Portugal Less << |
Tags: Cytisinicline | AChR | Plant Standard | Drug Analysis | Neuronal Signaling | 485-35-8
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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