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Chemical Structure| 1758-80-1 Chemical Structure| 1758-80-1

Structure of DABA
CAS No.: 1758-80-1

Chemical Structure| 1758-80-1

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L-DABA (L-2,4-Diaminobutyric acid) is a weak inhibitor of GABA transaminase with IC50 > 500 μM, exhibiting anti-tumor activity in vitro and in vivo.

Synonyms: L-2,4-Diaminobutyric acid; L-DABA

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Citations

Product Citations

Gao, Jinmin ; Liu, Shaonan ; Zhou, Chen ; Lara, Darwin ; Zou, Yike ; Hai, Yang

Abstract: Pyridoxal 5′-phosphate (PLP)-dependent enzymes catalyze a diverse range of chem. transformations. Despite their extraordinary functional diversity, no PLP-dependent enzyme is known to catalyze Mannich-type reactions, an important carbon-carbon bond-forming reaction in synthetic organic chem. Here we report the discovery of a biosynthetic enzyme LolT, a PLP-dependent enzyme catalyzing a stereoselective intramol. Mannich reaction to construct the pyrrolizidine core scaffold in loline alkaloids. Importantly, its versatile catalytic activity is harnessed for stereoselective synthesis of a variety of conformationally constrained α,α-disubstituted α-amino acids, which bear vicinal quaternary-tertiary stereocentres and various aza(bi)cyclic backbones, such as indolizidine, quinolizidine, pyrrolidine and piperidine. Furthermore, crystallog. and mutagenesis anal. and computational studies together provided mechanistic insights and structural basis for understanding LolT′s catalytic activity and stereoselectivity. Overall, this work expands the biocatalytic repertoire of carbon-carbon bond-forming enzymes and increases our knowledge of the catalytic versatility of PLP-dependent enzymes.

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Product Details of DABA

CAS No. :1758-80-1
Formula : C4H10N2O2
M.W : 118.13
SMILES Code : O=C(O)[C@@H](N)CCN
Synonyms :
L-2,4-Diaminobutyric acid; L-DABA
English Name :(S)-2,4-Diaminobutanoic acid
MDL No. :MFCD00082632
InChI Key :OGNSCSPNOLGXSM-VKHMYHEASA-N
Pubchem ID :134490

Safety of DABA

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

8.47mL

1.69mL

0.85mL

42.33mL

8.47mL

4.23mL

84.65mL

16.93mL

8.47mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
 

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