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Chemical Structure| 1110813-31-4 Chemical Structure| 1110813-31-4

Structure of Dacomitinib
CAS No.: 1110813-31-4

Chemical Structure| 1110813-31-4

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Dacomitinib is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.

Synonyms: PF-00299804; PF-299804; PF299

4.5 *For Research Use Only !

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Product Details of Dacomitinib

CAS No. :1110813-31-4
Formula : C24H25ClFN5O2
M.W : 469.94
SMILES Code : O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=C/CN4CCCCC4
Synonyms :
PF-00299804; PF-299804; PF299
MDL No. :MFCD19443734
InChI Key :LVXJQMNHJWSHET-AATRIKPKSA-N
Pubchem ID :11511120

Safety of Dacomitinib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Dacomitinib

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • EGFR/ErbB1

    EGFR, IC50:6.0 nM

  • HER2/ErbB2

    ErbB2, IC50:45.7 nM

  • ErbB4

    ErbB4, IC50:73.7 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02097433 Healthy PHASE1 COMPLETED 2025-09-14 Peking Union Medical College H... More >>ospital, Beijing, 100032, China Less <<
NCT00553254 Carcinoma, Non Small Cell Lung PHASE2 COMPLETED 2014-07-17 Seoul National University Hosp... More >>ital, Department of Internal Medicine, Seoul, 110-744, Korea, Republic of|Severance Hospital, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, 120-752, Korea, Republic of|Samsung Medical Center, Department of Medicine, Seoul, 135-710, Korea, Republic of Less <<
NCT04511533 Metastatic Non Small Cell Lung... More >> Cancer Less << PHASE4 COMPLETED 2022-11-08 Rajiv Gandhi Cancer Institute ... More >>And Research Centre, New Delhi, Delhi, 110085, India|The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, 380016, India|Hemato Oncology Clinic Ahmedabad Pvt. Ltd, Ahmedabad, Gujarat, 380054, India|Gujarat Hospital - Gastro & Vascular Centre, Surat, Gujarat, 395009, India|Unity Trauma Center And ICU (Unity Hospital ), Surat, Gujarat, 395009, India|Artemis hospital, Gurugram, Haryana, 122001, India|National Cancer Institute, Nagpur, Maharashtra, 441108, India|Apex Wellness Hospital, Nashik, Maharashtra, 422009, India|Grant Medical Foundation, Ruby Hall Clinic, Pune, Maharashtra, 411001, India|Sahyadri Clinical Research and Development Center, Pune, Maharashtra, 411004, India|Sahyadri Super Speciality Hospital, Pune, Maharashtra, 411004, India|Bhaktivedanta Hospital and Research Institute, Thane, Maharashtra, 401107, India|Yashoda Hospital, Hyderabad, Telangana State, 500082, India|Netaji Subhas Chandra Bose Cancer Hospital, Kolkata, WEST Bengal, 700094, India|Tata Medical Center, Kolkata, WEST Bengal, 700160, India Less <<
NCT01484847 Head and Neck Squamous Cell Ca... More >>rcinoma Less << COMPLETED 2025-07-15 Princess Margaret Hospital, To... More >>ronto, Ontario, M5G 2M9, Canada Less <<
NCT01116843 Oral Cavity Cancer PHASE1|PHASE2 COMPLETED 2025-02-14 Princess Margaret Hospital, To... More >>ronto, Ontario, M5G 2M9, Canada Less <<
NCT04768491 EGFR Activating Mutation|NSCLC... More >> Stage IV|NSCLC Stage IIIB|NSCLC, Recurrent Less << UNKNOWN 2024-10-31 National Cancer Center/Nationa... More >>l Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing, 100021, China Less <<
NCT02382796 NSCLC PHASE2 COMPLETED 2019-05-30 Kanazawa University Hospital, ... More >>Kanazawa City, Ishikawa, 9208641, Japan|Kurashiki Central Hospital, Kurashiki, Okayama, 710-8602, Japan|Osaka City General Hospital Department of Clinical Oncology, Osaka-city, Osaka, 534-0021, Japan|Kindai University Hospital, Osakasayama, Osaka, 589-8511, Japan|Shizuoka Cancer Center, Suntougun, Shizuoka, 411-8777, Japan|Cancer Institute Hospital,Japanese Foundation for Cancer Research, Koto-Ku, Tokyo, 135-8550, Japan Less <<
NCT00768664 Head and Neck Neoplasms PHASE2 COMPLETED 2012-04-18 BC Cancer Agency, Vancouver Ce... More >>ntre, Vancouver, British Columbia, V5Z 4E6, Canada|Fairmont Medical Building, Vancouver, British Columbia, V5Z1H7, Canada|Hamilton Health Sciences, Hamilton, Ontario, L8V 5C2, Canada|London Health Sciences Centre, London, Ontario, N6A 4L6, Canada|London Regional Cancer Centre, London, Ontario, N6A 4L6, Canada|The Ottawa Hospital Cancer Centre, Ottawa, Ontario, K1H 8L6, Canada|The Ottawa Hospital Cancer Centre, Ottawa, Ontario, K1Y 4K7, Canada|Sunnybrook Health Sciences Centre: Odette Cancer Center, Toronto, Ontario, M4N 3M5, Canada|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada|Hopital Notre-dame du CHUM - Oncology Center, Montreal, Quebec, H2L 4M1, Canada Less <<
NCT00728390 Carcinoma, Non-Small Cell|Neop... More >>lasm Metastasis Less << PHASE1 COMPLETED 2013-01-29 Pfizer Investigational Site, A... More >>mherst, New York, 14221, United States|Pfizer Investigational Site, Buffalo, New York, 14263, United States|Pfizer Investigational Site, San Antonio, Texas, 78229, United States|Pfizer Investigational Site, Villejuif, 94805, France|Pfizer Investigational Site, Madrid, 28050, Spain Less <<
NCT01728233 Penile Neoplasms|Carcinoma, Sq... More >>uamous Cell Less << PHASE2 COMPLETED 2018-09-21 Fondazione IRCCS Istituto Nazi... More >>onale dei Tumori, Milan, 20133, Italy Less <<
NCT02047747 Brain Cancer PHASE2 TERMINATED 2025-02-16 UCSD Moores Cancer Center, La ... More >>Jolla, California, 92093-0698, United States Less <<
NCT04339829 Dacomitinib for EGFR Mutated N... More >>on-Small Cell Lung Cancer (NSCLC) With Brain Metastases Less << PHASE2 UNKNOWN 2023-08-30 -
NCT00783328 Neoplasms PHASE1 COMPLETED 2025-03-11 Pfizer Investigational Site, S... More >>unto-gun, Shizuoka, Japan Less <<
NCT04675008 Non Small Cell Lung Cancer|Bra... More >>in Metastases Less << PHASE2 UNKNOWN 2023-03-01 Jong-Mu Sun, Seoul, 06351, Kor... More >>ea, Republic of Less <<
NCT01449201 Head Neck Cancer Squamous Cell... More >> Metastatic|Head Neck Cancer Squamous Cell Recurrent Less << PHASE2 COMPLETED 2025-03-14 Chilgok Kyungpook National Uni... More >>versity Hospital, Daegu, Korea, Republic of|Dongsan Medical Center, Daegu, Korea, Republic of|Severance Hospital, Seoul, 120-752, Korea, Republic of|Asan Medical Center, Seoul, Korea, Republic of|Samsung Medical Center, Seoul, Korea, Republic of|Seoul National University Hospital Cancer Center, Seoul, Korea, Republic of Less <<
NCT01112527 Glioblastoma|GBM|Glioblastoma ... More >>Multiforme Less << PHASE2 COMPLETED 2025-09-15 Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Henry Ford Hospital, Detroit, Michigan, 48202, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States Less <<
NCT00728468 Advanced Malignant Solid Tumor... More >>s Less << PHASE1 COMPLETED 2025-07-14 Roswell Park Cancer Institute,... More >> Buffalo, New York, 14263, United States|South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas, 78229, United States Less <<
NCT00971191 Non-Small Cell Lung Cancer (NS... More >>CLC) Less << PHASE1 TERMINATED 2025-05-12 Pfizer Investigational Site, B... More >>irmingham, Alabama, 35294, United States|Pfizer Investigational Site, Los Angeles, California, 90048, United States|Pfizer Investigational Site, Los Angeles, California, 90095, United States Less <<
NCT04609319 Lung Cancer COMPLETED 2024-05-28 Beijing Cancer Hospital, Beiji... More >>ng, Beijing, 100142, China|Guangdong Provincial People's Hospital, Guangzhou, Guangdong, 510080, China|The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China|Henan Cancer Hospital, Zhengzhou, Henan, 450008, China|Hunan Provincial Tumor Hospital, Changsha, Hunan, 410013, China|The First hospital of Jilin University, Changchun, Jilin, 130021, China|West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China|Internal Medicine, Chinese Academy of Medical Sciences Cancer Hospital, Beijing, 100021, China|The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China|Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, DEL, 110085, India|Tata Memorial Center, Kolkata, Kolkata, West Bengal, 700156, India|Pantai Hospital Kuala Lumpur, Kuala Lumpur, 59100, Malaysia|University Malaya Medical Centre, Kuala Lumpur, 59100, Malaysia|Beacon Hospital, Petaling Jaya, 46050, Malaysia Less <<
NCT03865446 Severe Hepatic Impairment PHASE1 COMPLETED 2019-10-24 Investigational Drug Services ... More >>(IDS) University of Miami Hospitals and Clinics, Research Pharmacy, Miami, Florida, 33136, United States|University of Miami Division of Clinical Pharmacology, Miami, Florida, 33136, United States|Orlando Clinical Research Center, Orlando, Florida, 32809, United States Less <<
NCT04027647 NSCLC Stage IIIB|NSCLC Stage I... More >>IIC|NSCLC Stage IV|Recurrent NSCLC|EGFR Positive Non-Small Cell Lung Cancer Less << PHASE2 ACTIVE_NOT_RECRUITING 2026-03-31 Prince of Wales Hospital, Hong... More >> Kong, Hong Kong|Dong-A University Hospital, Busan, Korea, Republic of|Seoul National University Hospital, Seoul, Korea, Republic of|Sarawak General Hospital, Kuching, Sarawak, Malaysia|University Malaya Medical Centre, Kuala Lumpur, Malaysia|Beacon Hospital, Petaling Jaya, Malaysia|National Cancer Centre Singapore, Singapore, Singapore|Phramongkutklao Hospital, Bangkok, Thailand|Ramathibodi Hospital, Bangkok, Thailand Less <<
NCT04504071 Non-small Cell Lung Cancer Met... More >>astatic|EGF-R Positive Non-Small Cell Lung Cancer Less << PHASE2 UNKNOWN 2025-12-22 Shanghai Chest hospital, Shang... More >>hai, Shanghai, 200030, China Less <<
NCT00225121 Neoplasms PHASE1 COMPLETED 2010-09-23 Ronald Reagan UCLA Medical Cen... More >>ter, Los Angeles, California, 90095, United States|UCLA Hematology/Oncology, Los Angeles, California, 90095, United States|UCLA Oncology Center, Los Angeles, California, 90095, United States|UCLA Hematology Oncology - Santa Monica, Santa Monica, California, 90404, United States|UCLA Santa Monica Hematology/Oncology, Santa Monica, California, 90404, United States|University of Colorado Hospital, Aurora, Colorado, 80045, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Vereniging het Nederlandse Kanker Instituut, Amsterdam, 1066 CX, Netherlands Less <<
NCT02268747 Skin Squamous Cell Cancer PHASE2 UNKNOWN 2025-11-16 Fondazione IRCCS Istituto Nazi... More >>onale dei Tumori, Milano, Milan, 20133, Italy Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.64mL

2.13mL

1.06mL

21.28mL

4.26mL

2.13mL

References

 

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