Structure of Dacomitinib
CAS No.: 1110813-31-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Dacomitinib is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
Synonyms: PF-00299804; PF-299804; PF299
4.5
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 1110813-31-4 |
Formula : | C24H25ClFN5O2 |
M.W : | 469.94 |
SMILES Code : | O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=C/CN4CCCCC4 |
Synonyms : |
PF-00299804; PF-299804; PF299
|
MDL No. : | MFCD19443734 |
InChI Key : | LVXJQMNHJWSHET-AATRIKPKSA-N |
Pubchem ID : | 11511120 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
|
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02097433 | Healthy | PHASE1 | COMPLETED | 2025-09-14 | Peking Union Medical College H... More >>ospital, Beijing, 100032, China Less << |
NCT00553254 | Carcinoma, Non Small Cell Lung | PHASE2 | COMPLETED | 2014-07-17 | Seoul National University Hosp... More >>ital, Department of Internal Medicine, Seoul, 110-744, Korea, Republic of|Severance Hospital, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, 120-752, Korea, Republic of|Samsung Medical Center, Department of Medicine, Seoul, 135-710, Korea, Republic of Less << |
NCT04511533 | Metastatic Non Small Cell Lung... More >> Cancer Less << | PHASE4 | COMPLETED | 2022-11-08 | Rajiv Gandhi Cancer Institute ... More >>And Research Centre, New Delhi, Delhi, 110085, India|The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, 380016, India|Hemato Oncology Clinic Ahmedabad Pvt. Ltd, Ahmedabad, Gujarat, 380054, India|Gujarat Hospital - Gastro & Vascular Centre, Surat, Gujarat, 395009, India|Unity Trauma Center And ICU (Unity Hospital ), Surat, Gujarat, 395009, India|Artemis hospital, Gurugram, Haryana, 122001, India|National Cancer Institute, Nagpur, Maharashtra, 441108, India|Apex Wellness Hospital, Nashik, Maharashtra, 422009, India|Grant Medical Foundation, Ruby Hall Clinic, Pune, Maharashtra, 411001, India|Sahyadri Clinical Research and Development Center, Pune, Maharashtra, 411004, India|Sahyadri Super Speciality Hospital, Pune, Maharashtra, 411004, India|Bhaktivedanta Hospital and Research Institute, Thane, Maharashtra, 401107, India|Yashoda Hospital, Hyderabad, Telangana State, 500082, India|Netaji Subhas Chandra Bose Cancer Hospital, Kolkata, WEST Bengal, 700094, India|Tata Medical Center, Kolkata, WEST Bengal, 700160, India Less << |
NCT01484847 | Head and Neck Squamous Cell Ca... More >>rcinoma Less << | COMPLETED | 2025-07-15 | Princess Margaret Hospital, To... More >>ronto, Ontario, M5G 2M9, Canada Less << | |
NCT01116843 | Oral Cavity Cancer | PHASE1|PHASE2 | COMPLETED | 2025-02-14 | Princess Margaret Hospital, To... More >>ronto, Ontario, M5G 2M9, Canada Less << |
NCT04768491 | EGFR Activating Mutation|NSCLC... More >> Stage IV|NSCLC Stage IIIB|NSCLC, Recurrent Less << | UNKNOWN | 2024-10-31 | National Cancer Center/Nationa... More >>l Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing, 100021, China Less << | |
NCT02382796 | NSCLC | PHASE2 | COMPLETED | 2019-05-30 | Kanazawa University Hospital, ... More >>Kanazawa City, Ishikawa, 9208641, Japan|Kurashiki Central Hospital, Kurashiki, Okayama, 710-8602, Japan|Osaka City General Hospital Department of Clinical Oncology, Osaka-city, Osaka, 534-0021, Japan|Kindai University Hospital, Osakasayama, Osaka, 589-8511, Japan|Shizuoka Cancer Center, Suntougun, Shizuoka, 411-8777, Japan|Cancer Institute Hospital,Japanese Foundation for Cancer Research, Koto-Ku, Tokyo, 135-8550, Japan Less << |
NCT00768664 | Head and Neck Neoplasms | PHASE2 | COMPLETED | 2012-04-18 | BC Cancer Agency, Vancouver Ce... More >>ntre, Vancouver, British Columbia, V5Z 4E6, Canada|Fairmont Medical Building, Vancouver, British Columbia, V5Z1H7, Canada|Hamilton Health Sciences, Hamilton, Ontario, L8V 5C2, Canada|London Health Sciences Centre, London, Ontario, N6A 4L6, Canada|London Regional Cancer Centre, London, Ontario, N6A 4L6, Canada|The Ottawa Hospital Cancer Centre, Ottawa, Ontario, K1H 8L6, Canada|The Ottawa Hospital Cancer Centre, Ottawa, Ontario, K1Y 4K7, Canada|Sunnybrook Health Sciences Centre: Odette Cancer Center, Toronto, Ontario, M4N 3M5, Canada|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada|Hopital Notre-dame du CHUM - Oncology Center, Montreal, Quebec, H2L 4M1, Canada Less << |
NCT00728390 | Carcinoma, Non-Small Cell|Neop... More >>lasm Metastasis Less << | PHASE1 | COMPLETED | 2013-01-29 | Pfizer Investigational Site, A... More >>mherst, New York, 14221, United States|Pfizer Investigational Site, Buffalo, New York, 14263, United States|Pfizer Investigational Site, San Antonio, Texas, 78229, United States|Pfizer Investigational Site, Villejuif, 94805, France|Pfizer Investigational Site, Madrid, 28050, Spain Less << |
NCT01728233 | Penile Neoplasms|Carcinoma, Sq... More >>uamous Cell Less << | PHASE2 | COMPLETED | 2018-09-21 | Fondazione IRCCS Istituto Nazi... More >>onale dei Tumori, Milan, 20133, Italy Less << |
NCT02047747 | Brain Cancer | PHASE2 | TERMINATED | 2025-02-16 | UCSD Moores Cancer Center, La ... More >>Jolla, California, 92093-0698, United States Less << |
NCT04339829 | Dacomitinib for EGFR Mutated N... More >>on-Small Cell Lung Cancer (NSCLC) With Brain Metastases Less << | PHASE2 | UNKNOWN | 2023-08-30 | - |
NCT00783328 | Neoplasms | PHASE1 | COMPLETED | 2025-03-11 | Pfizer Investigational Site, S... More >>unto-gun, Shizuoka, Japan Less << |
NCT04675008 | Non Small Cell Lung Cancer|Bra... More >>in Metastases Less << | PHASE2 | UNKNOWN | 2023-03-01 | Jong-Mu Sun, Seoul, 06351, Kor... More >>ea, Republic of Less << |
NCT01449201 | Head Neck Cancer Squamous Cell... More >> Metastatic|Head Neck Cancer Squamous Cell Recurrent Less << | PHASE2 | COMPLETED | 2025-03-14 | Chilgok Kyungpook National Uni... More >>versity Hospital, Daegu, Korea, Republic of|Dongsan Medical Center, Daegu, Korea, Republic of|Severance Hospital, Seoul, 120-752, Korea, Republic of|Asan Medical Center, Seoul, Korea, Republic of|Samsung Medical Center, Seoul, Korea, Republic of|Seoul National University Hospital Cancer Center, Seoul, Korea, Republic of Less << |
NCT01112527 | Glioblastoma|GBM|Glioblastoma ... More >>Multiforme Less << | PHASE2 | COMPLETED | 2025-09-15 | Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Henry Ford Hospital, Detroit, Michigan, 48202, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States Less << |
NCT00728468 | Advanced Malignant Solid Tumor... More >>s Less << | PHASE1 | COMPLETED | 2025-07-14 | Roswell Park Cancer Institute,... More >> Buffalo, New York, 14263, United States|South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas, 78229, United States Less << |
NCT00971191 | Non-Small Cell Lung Cancer (NS... More >>CLC) Less << | PHASE1 | TERMINATED | 2025-05-12 | Pfizer Investigational Site, B... More >>irmingham, Alabama, 35294, United States|Pfizer Investigational Site, Los Angeles, California, 90048, United States|Pfizer Investigational Site, Los Angeles, California, 90095, United States Less << |
NCT04609319 | Lung Cancer | COMPLETED | 2024-05-28 | Beijing Cancer Hospital, Beiji... More >>ng, Beijing, 100142, China|Guangdong Provincial People's Hospital, Guangzhou, Guangdong, 510080, China|The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China|Henan Cancer Hospital, Zhengzhou, Henan, 450008, China|Hunan Provincial Tumor Hospital, Changsha, Hunan, 410013, China|The First hospital of Jilin University, Changchun, Jilin, 130021, China|West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China|Internal Medicine, Chinese Academy of Medical Sciences Cancer Hospital, Beijing, 100021, China|The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China|Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, DEL, 110085, India|Tata Memorial Center, Kolkata, Kolkata, West Bengal, 700156, India|Pantai Hospital Kuala Lumpur, Kuala Lumpur, 59100, Malaysia|University Malaya Medical Centre, Kuala Lumpur, 59100, Malaysia|Beacon Hospital, Petaling Jaya, 46050, Malaysia Less << | |
NCT03865446 | Severe Hepatic Impairment | PHASE1 | COMPLETED | 2019-10-24 | Investigational Drug Services ... More >>(IDS) University of Miami Hospitals and Clinics, Research Pharmacy, Miami, Florida, 33136, United States|University of Miami Division of Clinical Pharmacology, Miami, Florida, 33136, United States|Orlando Clinical Research Center, Orlando, Florida, 32809, United States Less << |
NCT04027647 | NSCLC Stage IIIB|NSCLC Stage I... More >>IIC|NSCLC Stage IV|Recurrent NSCLC|EGFR Positive Non-Small Cell Lung Cancer Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2026-03-31 | Prince of Wales Hospital, Hong... More >> Kong, Hong Kong|Dong-A University Hospital, Busan, Korea, Republic of|Seoul National University Hospital, Seoul, Korea, Republic of|Sarawak General Hospital, Kuching, Sarawak, Malaysia|University Malaya Medical Centre, Kuala Lumpur, Malaysia|Beacon Hospital, Petaling Jaya, Malaysia|National Cancer Centre Singapore, Singapore, Singapore|Phramongkutklao Hospital, Bangkok, Thailand|Ramathibodi Hospital, Bangkok, Thailand Less << |
NCT04504071 | Non-small Cell Lung Cancer Met... More >>astatic|EGF-R Positive Non-Small Cell Lung Cancer Less << | PHASE2 | UNKNOWN | 2025-12-22 | Shanghai Chest hospital, Shang... More >>hai, Shanghai, 200030, China Less << |
NCT00225121 | Neoplasms | PHASE1 | COMPLETED | 2010-09-23 | Ronald Reagan UCLA Medical Cen... More >>ter, Los Angeles, California, 90095, United States|UCLA Hematology/Oncology, Los Angeles, California, 90095, United States|UCLA Oncology Center, Los Angeles, California, 90095, United States|UCLA Hematology Oncology - Santa Monica, Santa Monica, California, 90404, United States|UCLA Santa Monica Hematology/Oncology, Santa Monica, California, 90404, United States|University of Colorado Hospital, Aurora, Colorado, 80045, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Vereniging het Nederlandse Kanker Instituut, Amsterdam, 1066 CX, Netherlands Less << |
NCT02268747 | Skin Squamous Cell Cancer | PHASE2 | UNKNOWN | 2025-11-16 | Fondazione IRCCS Istituto Nazi... More >>onale dei Tumori, Milano, Milan, 20133, Italy Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.13mL 0.43mL 0.21mL |
10.64mL 2.13mL 1.06mL |
21.28mL 4.26mL 2.13mL |
Tags: Dacomitinib | PF-00299804 | Apoptosis Inducer | Tyrosine / EGF Receptor Protein Kinase Inhibitor | HER2 | EGFR | ErbB | Enzyme Inhibitors | Angiogenesis | Cell Apoptosis/Death Detection | Parkinson'S Disease and Alzheimer'S Disease | Apoptosis | JAK-STAT-Signaling | Tumor Growth, Proliferation and Apoptosis | Tumor Development and Microenvironment Evolution | Protein Tyrosine Kinase/RTK | 1110813-31-4
Precautionary Statements-General | |
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P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
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P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
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P243 | Take precautionary measures against static discharge. |
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P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
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P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
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P502 | Refer to manufacturer/supplier for information on recovery/recycling |
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Code | Phrase |
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H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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