Dasatinib (BMS-354825) monohydrate | Src/Bcr-Abl Inhibitor

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	863127-77-9
Formula :	C₂₂H₂₈ClN₇O₃S
M.W :	506.02
SMILES Code :	O.CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(Cl)C=CC=C2C)=CC(=N1)N1CCN(CCO)CC1
Synonyms :	BMS-354825 monohydrate; Dasatinib(monohydrate)
MDL No. :	MFCD08704581
InChI Key :	XHXFZZNHDVTMLI-UHFFFAOYSA-N
Pubchem ID :	11540687

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

NALM6 cells	100, 150, 200, 250, 300 nM	48 h	The combination of dexamethasone and dasatinib showed highly synergistic effects in NALM6 cells, resulting in increased apoptosis.	PMC10203345
REH GCR cells	100, 150, 200, 250, 300 nM	48 h	The combination of dexamethasone and dasatinib showed additive effects in REH GCR cells, resulting in increased apoptosis.	PMC10203345
NK92 cells	100nM	48 and 72 h	Dasatinib significantly suppressed the expression of NKG2A to one-third or even one-quarter	PMC6344416
NK92 cells	100nM	48 h	Dasatinib significantly diminished NKG2A protein expression and reduced phosphorylated p38 MAPK expression	PMC6344416
SKM-1 cells	50 nM	24 h	Dasatinib at concentrations above 50 nM prevented cytokine release and switched off-target cell killing, which were subsequently restored on removal of dasatinib.	PMC8323395
PBMCs	100 nM	24 h	Dasatinib at 100 nM significantly inhibited HLA-A2 WT1-TCB-induced SKM-1 cell killing as well as T cell proliferation and activation.	PMC8323395
Human bone marrow-derived mesenchymal stem cells (BM-MSCs)	1 μM	21 days	Dasatinib inhibited the viability and adipogenesis commitment of human BM-MSCs, reducing adipocyte differentiation.	PMC10436421
DAOY cells	1, 5, 10, 50, 100 nM	1–24 h	Dasatinib significantly inhibited the proliferation of DAOY cells and induced apoptosis and autophagy.	PMC4179499
D556 cells	1, 5, 10, 50, 100 nM	1–24 h	Dasatinib significantly inhibited the proliferation of D556 cells and induced apoptosis and autophagy.	PMC4179499
PS125 cells	3, 10 nM		Combined treatment with Dasatinib and AT9283 significantly inhibited the proliferation of PS125 cells.	PMC4179499
K562 leukemia cells	10nM		Combined inhibition of JAK2 with SAR302503 and BCR-ABL1 with dasatinib significantly inhibited their self-renewal potential	PMC4975616
p190 cells	5 nM	48 h	To evaluate the effect of Dasatinib on the growth of p190 cells, results showed that Dasatinib fully suppressed cell growth.	PMC4017764
SUP-B15 cells	5 nM	48 h	To evaluate the effect of Dasatinib on the growth of SUP-B15 cells, results showed that Dasatinib fully suppressed cell growth.	PMC4017764
K562 cells	5 nM	48 h	To evaluate the effect of Dasatinib on the growth of K562 cells, results showed that Dasatinib fully suppressed cell growth.	PMC4017764

Mice	NALM6-Luc+ xenograft model	Oral gavage	35 mg/kg	Twice daily for 14 days	The combination of dasatinib and dexamethasone significantly reduced tumor burden and prolonged survival in mice.	PMC10203345
Mice	BCR-ABL-positive B-cell acute lymphoblastic leukemia model	Oral gavage	10 mg/kg	Once daily for 21 days	Dasatinib treatment significantly extended the survival of mice with XRCC4/Polθ/p53-deficient leukemic B cells, indicating that Dasatinib can selectively eliminate these leukemic cells after inducing G1 DNA damage.	PMC7567796
NSG mice	Humanized NSG mice	Oral	50 mg/kg	On day 0, 1 hour before, 5 hours and 8 hours after injection, and twice daily on days 1 and 2 with 10-11 hour intervals	Dasatinib at 50 mg/kg successfully prevented CD19-TCB-mediated B cell depletion and cytokine release within 48 hours.	PMC8323395
Mice	db/db mice	Oral gavage	5 mg/kg	Once per week for four weeks	Dasatinib reduced lipid accumulation in the heart and bone marrow of diabetic mice, improved diastolic function, and attenuated cardiac fibrosis.	PMC10436421
Mice	PS125 mouse Shh MB model	Oral	15 mg/kg	Once daily for 5 consecutive days per week for 4 weeks	Dasatinib significantly inhibited PS125 tumor growth in mice and induced tumor regression.	PMC4179499
mice	humanized BC CML mouse model	oral	50 mg/kg	daily for two weeks	Dasatinib alone or in combination with SAR302503 significantly inhibited BC LSC survival and self-renewal potential	PMC4975616
mice	SUP-B15ffLuc xenograft model	oral	2.5 mg/kg	daily doses throughout the full treatment duration	To evaluate the effect of Dasatinib on leukemia cell expansion in the SUP-B15ffLuc xenograft model, results showed that Dasatinib alone modestly delayed leukemia expansion, but the combination with PP242 caused regression of leukemic disease.	PMC4017764

{[proInfo.proName]}

CAS No.: 863127-77-9

{[proInfo.proName]}

CAS No.: 863127-77-9

Alternative Products

Product Details of Dasatinib monohydrate

Safety of Dasatinib monohydrate

Related Pathways of Dasatinib monohydrate

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

NCT02883049	B Acute Lymphoblastic Leukemia... More >> Central Nervous System Leukemia Ph-Like Acute Lymphoblastic Leukemia Testicular Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Less <<	Phase 3	Recruiting	-	-
NCT00390793	Acute Lymphoblastic Leukemia ... More >> BCR-ABL1 Fusion Protein Expression Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Philadelphia Chromosome Positive Recurrent Acute Lymphoblastic Leukemia t(9;22) Less <<	Phase 2	Active, not recruiting	August 31, 2020	United States, Texas ... More >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT02143414	Acute Lymphoblastic Leukemia ... More >> B Acute Lymphoblastic Leukemia B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative Philadelphia Chromosome Positive Recurrent Adult Acute Lymphoblastic Leukemia Refractory Adult Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Less <<	Phase 2	Recruiting	-	-
NCT00720109	Adult B Acute Lymphoblastic Le... More >>ukemia With t(9;22)(q34;q11.2); BCR-ABL1 Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Less <<	Phase 2 Phase 3	Completed	-	-
NCT00720109	-		Completed	-	-
NCT03625388	Chronic Myelogenous Leukemia	Phase 2	Not yet recruiting	July 2021	Jordan ... More >> King Hussein Cancer Center (KHCC) Not yet recruiting Amman, Jordan, 11941 Jordan University Hospital (JUH) Not yet recruiting Amman, Jordan, 11942 Lebanon American University of Beirut Medical Center (AUBMC) Not yet recruiting Beirut, Lebanon Saudi Arabia The King Faisal Specialist Hospital and Research Centre (KFSH&RC) Not yet recruiting Riyadh, Saudi Arabia Tunisia Aziza Othmana Hospital Not yet recruiting Tunis, Tunisia, 1006 Less <<
NCT01256398	Acute Lymphoblastic Leukemia ... More >> Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 Untreated Adult Acute Lymphoblastic Leukemia Less <<	Phase 2	Active, not recruiting	-	-
NCT02596828	Pineoblastoma	Phase 2	Recruiting	April 2020	Germany ... More >> University Hospital of Regensburg Recruiting Regensburg, Germany, 93053 Contact: Selim Corbacioglu, MD 0043 (0)941 944 ext 2101 kinderonkologie@ukr.de Contact: Susanne Ellinger 0043 (0)941 944 ext 2063 susanne.ellinger@ukr.de Less <<
NCT01467986	Neuroblastoma Recurrent	Phase 2	Recruiting	December 2019	Germany ... More >> University Hospital Regensburg, Department of Pediatric Hematology and Oncology Recruiting Regensburg, Germany, 93053 Contact: Selim Corbacioglu, MD +49(0)941 944-2101 selim.corbacioglu@ukr.de Principal Investigator: Selim Corbacioglu, MD Less <<

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	1.98mL 0.40mL 0.20mL	9.88mL 1.98mL 0.99mL	19.76mL 3.95mL 1.98mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed