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Chemical Structure| 593273-05-3 Chemical Structure| 593273-05-3

Structure of DCH36_06
CAS No.: 593273-05-3

Chemical Structure| 593273-05-3

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DCH36_06 is a highly efficient and selective p300/CBP inhibitor, with IC50 values of 0.6 μM (p300) and 3.2 μM (CBP). This inhibition leads to low acetylation of H3K18 in leukemia cells, exhibiting anti-tumor activity.

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Product Details of DCH36_06

CAS No. :593273-05-3
Formula : C18H13ClN2O3S
M.W : 372.83
SMILES Code : O=C(/C(C(N1C2=CC=C(C)C(Cl)=C2)=O)=C\C=C\C3=CC=CO3)NC1=S
MDL No. :MFCD03864746
InChI Key :AYNCXNUUERDREH-FMDPHQNASA-N
Pubchem ID :1797299

Safety of DCH36_06

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of DCH36_06

epigenetics

Isoform Comparison

Biological Activity

Description
DCH36_06, a potent and selective p300/CBP inhibitor, exhibits IC50s of 0.6 μM for p300 and 3.2 μM for CBP. It induces hypoacetylation of H3K18 in leukemic cells and demonstrates anti-tumor activity [1].

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2.68mL

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26.82mL

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2.68mL

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