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Chemical Structure| 5302-45-4 Chemical Structure| 5302-45-4

Structure of Dencichine
CAS No.: 5302-45-4

Chemical Structure| 5302-45-4

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β-ODAP is an analog of glutamic acid present in Lathyrus sativus (grass pea) that activates AMPA receptors.

Synonyms: ODAP; Dencichin; Ox-Dapro

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Product Details of Dencichine

CAS No. :5302-45-4
Formula : C5H8N2O5
M.W : 176.13
SMILES Code : O=C(O)[C@@H](N)CNC(C(O)=O)=O
Synonyms :
ODAP; Dencichin; Ox-Dapro
MDL No. :MFCD00055228

Safety of Dencichine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H319-H372-H410
Precautionary Statements:P260-P264-P273-P301+P312-P305+P351+P338-P314
Class:9
UN#:3077
Packing Group:

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.68mL

1.14mL

0.57mL

28.39mL

5.68mL

2.84mL

56.78mL

11.36mL

5.68mL

References

[1]Eslavath RK, Sharma D, et al. β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411.

[2]Jammulamadaka N, Burgula S, et al. β-N-oxalyl-L-α,β-diaminopropionic acid regulates mitogen-activated protein kinase signaling by down-regulation of phosphatidylethanolamine-binding protein 1. J Neurochem. 2011 Jul;118(2):176-86.

[3]Lin CY, Lynch G, Gall CM. AMPA receptor stimulation increases alpha5beta1 integrin surface expression, adhesive function and signaling. J Neurochem. 2005 Jul;94(2):531-46

[4]Kusama-Eguchi K, Ikegami F, Kusama T, Lambein F, Watanabe K. Effects of β-ODAP and its biosynthetic precursor on the electrophysiological activity of cloned glutamate receptors. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):339-42

[5]Kusama-Eguchi K, Miyano T, Yamamoto M, Suda A, Ito Y, Ishige K, Ishii M, Ogawa Y, Watanabe K, Ikegami F, Kusama T. New insights into the mechanism of neurolathyrism: L-β-ODAP triggers [Ca2+]i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors. Food Chem Toxicol. 2014 May;67:113-22

[6]Jiao CJ, Jiang JL, Ke LM, Cheng W, Li FM, Li ZX, Wang CY. Factors affecting β-ODAP content in Lathyrus sativus and their possible physiological mechanisms. Food Chem Toxicol. 2011 Mar;49(3):543-9

[7]Xiong JL, Bai X, Batool A, Kong HY, Tan RY, Wang YF, Li ZX, Xiong YC. [Ecological function and application of toxin beta-ODAP in grass pea (Lathyrus sativus)]. Ying Yong Sheng Tai Xue Bao. 2014 Apr;25(4):1197-205. Chinese

 

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