Structure of Desloratadine
CAS No.: 100643-71-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Desloratadine is an antagonist of histamine H1 receptor that is used to treat allergies.
Synonyms: Sch34117; Descarboethoxyloratadine; Aerius
4.5
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| CAS No. : | 100643-71-8 |
| Formula : | C19H19ClN2 |
| M.W : | 310.82 |
| SMILES Code : | ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1 |
| Synonyms : |
Sch34117; Descarboethoxyloratadine; Aerius
|
| MDL No. : | MFCD00871949 |
| InChI Key : | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| Pubchem ID : | 124087 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H302-H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
| Target |
|
In Vitro:
| Concentration | Treated Time | Description | References |
| CHO-K1 cells | 3.48 μM | Evaluate the inhibitory effect of DLT on 5HT2AR | Aging Cell. 2021 Jan;20(1):e13286. | |
| HepG2 cells | 2-10 μg/ml | 48 hours | To evaluate the inhibitory effect of desloratadine on HCC cell proliferation, results showed significant reduction in cell viability | Signal Transduct Target Ther. 2023 Jan 9;8(1):14 |
| Huh7 cells | 2-10 μg/ml | 48 hours | To evaluate the inhibitory effect of desloratadine on HCC cell proliferation, results showed significant reduction in cell viability | Signal Transduct Target Ther. 2023 Jan 9;8(1):14 |
| Hep3B cells | 6 μg/ml | Inhibited cell proliferation | Signal Transduct Target Ther. 2023 Jan 9;8(1):14. | |
| SK-Hep1 cells | 6 μg/ml | Inhibited cell proliferation | Signal Transduct Target Ther. 2023 Jan 9;8(1):14. | |
| HepG2 cells | 2-10 μg/ml | 48 h | Inhibited HCC cell proliferation and induced apoptosis | Signal Transduct Target Ther. 2023 Jan 9;8(1):14. |
| Huh7 cells | 2-10 μg/ml | 48 h | Inhibited HCC cell proliferation and induced apoptosis | Signal Transduct Target Ther. 2023 Jan 9;8(1):14. |
| human small airway epithelial cells (AEC) | 16 µM, 32 µM, 64 µM | 2 h | Desloratadine reduced the SPRBD-induced increases in CHST15 and CHST11 mRNA expression and partially reversed the SPRBD-induced declines in ARSB activity and expression. | Signal Transduct Target Ther. 2024 Feb 14;9(1):39. |
| ACE2 overexpressing HEK293T cells | 1, 5, 10, 20 μM | 48 h | To evaluate the inhibitory effect of Desloratadine on the entry of SARS-CoV-2 pseudotyped virus into cells, results showed that Desloratadine significantly inhibited the viral entry and was more effective than Loratadine | Chem Biol Interact. 2021 Apr 1;338:109420. |
In Vivo:
| Administration | Dosage | Frequency | Description | References |
| APP/PS1 mice | Alzheimer's disease model | Oral | 20 mg/kg/day | Once daily for three months | DLT ameliorated pathological behavior of APP/PS1 mice by antagonizing 5HT2AR, including improving short-term working memory defect, spatial working memory defect, and learning performance defect. | Aging Cell. 2021 Jan;20(1):e13286. |
| APP/PS1 mice | Alzheimer's disease model mice | Oral | 20 mg/kg/day | Once daily for three months | Evaluate the ameliorative effect of DLT on pathological behavior of APP/PS1 mice | Aging Cell. 2021 Jan;20(1):e13286. |
| Nude mice | HCC xenograft model | Oral | 15 or 45 mg/kg | Once every two days for 2-3 weeks | To evaluate the inhibitory effect of desloratadine on HCC tumor growth, results showed significant suppression of tumor growth | Signal Transduct Target Ther. 2023 Jan 9;8(1):14 |
| Nude mice | Huh7 and HepG2 cells-derived xenograft models | Oral | 15 or 45 mg/kg | Once every two days for 2-3 weeks | Significantly suppressed tumor growth | Signal Transduct Target Ther. 2023 Jan 9;8(1):14. |
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT00884325 | - | Completed | - | - | |
| NCT03724240 | Hay Fever | Phase 3 | Not yet recruiting | December 2019 | - |
| NCT03517930 | Clinical Pharmacology | Phase 1 | Completed | - | United States, New Jersey ... More >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Less << |
| NCT00866788 | Chronic Idiopathic Urticaria | Phase 2 | Completed | - | - |
| NCT00866788 | - | Completed | - | - | |
| NCT00633919 | - | Completed | - | - | |
| NCT00310466 | Allergy | Phase 3 | Completed | - | Germany ... More >> Charité Klinik für Dermatologie, Venerologie und Allergologie Berlin, Germany, D-10117 Less << |
| NCT00633919 | Allergy | Phase 2 Phase 3 | Completed | - | Spain ... More >> Fernando Rodríguez Santander, Cantabria, Spain Less << |
| NCT00310466 | - | Completed | - | - | |
| NCT01940393 | Urticaria | Phase 4 | Completed | - | Colombia ... More >> Medellin Medellin, Antioquia, Colombia Less << |
| NCT02593747 | Histamine H1 Antagonists, Non-... More >>Sedating Less << | Phase 1 | Completed | - | Germany ... More >> Neu-Ulm, Bayern, Germany, 89231 Less << |
| NCT00884325 | Atopic Dermatitis ... More >> Pruritus Less << | Phase 4 | Completed | - | United States, Kentucky ... More >> DermResearch, PLLC Louisville, Kentucky, United States, 40217 Less << |
| NCT00730912 | - | Completed | - | - | |
| NCT03517943 | Clinical Pharmacology | Phase 1 | Completed | - | United States, New Jersey ... More >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Less << |
| NCT01740284 | Allergic Rhinoconjunctivitis | Phase 3 | Completed | - | Germany ... More >> Zentrum für Rhinologie und Allergologie Wiesbaden, Germany, 65183 Less << |
| NCT00730912 | Perennial Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT00160537 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT01985789 | Asthma | Phase 4 | Completed | - | Canada, Saskatchewan ... More >> University of Saskatchewan Saskatoon, Saskatchewan, Canada, S7N 0W8 Less << |
| NCT00521170 | Allergy | Phase 1 | Completed | - | France ... More >> Illkirch, France Strasbourg, France Less << |
| NCT00160589 | Rhinitis, Allergic, Perennial | Phase 4 | Completed | - | - |
| NCT03751111 | Chronic Pruritus | Phase 1 Phase 2 | Not yet recruiting | February 1, 2019 | - |
| NCT00967967 | Asthma Rhinit... More >>is Less << | Not Applicable | Suspended(Awaiting results fro... More >>m sub analysis to decide if study continuesé) Less << | September 2014 | Canada, Quebec ... More >> Institut universitaire de cardiologie et de pneumologie de Québec Québec, Quebec, Canada, G1V 4G5 Less << |
| NCT01400828 | Seasonal Allergic Rhinitis | Phase 3 | Completed | - | Korea, Republic of ... More >> Yonsei University college of Medicine, Gangnam Severance Hospital Seoul, Korea, Republic of Less << |
| NCT02507635 | Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT00264303 | Chronic Idiopathic Urticaria | Phase 4 | Completed | - | - |
| NCT00346606 | Chronic Idiopathic Urticaria ... More >> Urticaria Less << | Phase 4 | Unknown | - | Taiwan ... More >> Department of Dermatology National Taiwan University Hospital Recruiting Taipei, Taiwan Contact: Jia-Yu Chu +886-2-23123456 ext 5734 Principal Investigator: Jia-Yu Chu Less << |
| NCT00636870 | Allergic Rhinitis | Phase 4 | Completed | - | United States, New Jersey ... More >> Sanofi-Aventis Bridgewater, New Jersey, United States, 08807 Less << |
| NCT00637585 | Allergic Rhinitis | Phase 4 | Completed | - | United States, New Jersey ... More >> Sanofi-Aventis Bridgewater, New Jersey, United States, 08807 Less << |
| NCT01529229 | Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00424580 | Asthma | Not Applicable | Completed | - | Canada, Saskatchewan ... More >> Room 346 Ellis Hall Saskatoon, Saskatchewan, Canada, S7N 0W8 Less << |
| NCT01720485 | Allergic Rhinitis | Phase 3 | Unknown | March 2014 | Brazil ... More >> IMA - Instituto de Pesquisa Clínica e Medicina Avançada Not yet recruiting São Paulo, Brazil Contact: Fabio M Castro, MD 55 11 38639156 daniela.fakih@imabrasil.com Principal Investigator: Fabio M Castro, MD Less << |
| NCT00264303 | - | Completed | - | - | |
| NCT01108783 | Seasonal Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00751218 | Urticaria | Phase 4 | Completed | - | - |
| NCT00723736 | Rhinitis|Urticaria | COMPLETED | 2025-06-08 | - | |
| NCT00862225 | Seasonal Allergic Rhinitis | Phase 2 | Completed | - | Germany ... More >> Dept. of Otorhinolaryngology and Head and Neck Surgery Dusseldorf, Germany Less << |
| NCT00723736 | Rhinitis|Urticaria | COMPLETED | 2025-06-08 | - | |
| NCT00311844 | Conjunctivitis, Allergic | Phase 4 | Completed | - | - |
| NCT01916967 | Urticaria | Phase 3 | Completed | - | - |
| NCT00751166 | Urticaria | Phase 4 | Terminated(Study could not be ... More >>re-supplied with study medication in a timely manner.) Less << | - | - |
| NCT01916967 | - | Completed | - | - | |
| NCT00816972 | Post-nasal Drip ... More >> Seasonal Allergic Rhinitis Rhinorrhea Less << | Phase 2 | Completed | - | - |
| NCT01529242 | Cutaneous Hypersensitivity | Phase 3 | Terminated(By sponsor decision... More >> due to difficulty of recruitment) Less << | - | Brazil ... More >> Alergoalpha São Paulo, SP, Brazil Allergisa Campinas, São Paulo, Brazil Hospital Nipo Brasileiro São Paulo, Brazil Less << |
| NCT00600847 | Acquired Cold Urticaria | Phase 4 | Completed | - | Germany ... More >> Allergie-Centrum-Charité Berlin Berlin, Germany, 10117 Less << |
| NCT00359138 | Hypersensitivity | Phase 4 | Completed | - | - |
| NCT01918033 | - | Completed | - | - | |
| NCT00359138 | - | Completed | - | - | |
| NCT02320396 | Seasonal Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00783211 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT01918033 | Perennial Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00795522 | Urticaria | PHASE4 | COMPLETED | 2025-03-05 | - |
| NCT00783133 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT00794248 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT00794768 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT00783354 | Urticaria Chr... More >>onic Idiopathic Urticaria Less << | Phase 4 | Completed | - | - |
| NCT00794495 | Seasonal Allergic Rhinitis ... More >> Perennial Allergic Rhinitis Less << | Phase 4 | Completed | - | - |
| NCT00794599 | Seasonal Allergic Rhinitis ... More >> Perennial Allergic Rhinitis Less << | Phase 4 | Completed | - | - |
| NCT02320396 | - | Completed | - | - | |
| NCT01444196 | Urticaria | PHASE4 | COMPLETED | 2025-05-10 | Department of Dermatology, Ven... More >>erology and Allergology, Berlin, 10117, Germany Less << |
| NCT00598611 | Chronic Urticaria | Phase 3 | Completed | - | Germany ... More >> Allergie-Centrum-Charite Berlin, Germany, 10117 Less << |
| NCT01916980 | Eczema Dermat... More >>itis Dermal Pruritus Less << | Phase 3 | Completed | - | - |
| NCT00783146 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT00406783 | Rhinitis, Allergic, Seasonal ... More >> Rhinitis, Allergic, Perennial Less << | Phase 3 | Completed | - | - |
| NCT00406783 | - | Completed | - | - | |
| NCT00794846 | Seasonal Allergic Rhinitis ... More >> Perennial Allergic Rhinitis Less << | Phase 4 | Completed | - | - |
| NCT00704769 | - | Completed | - | - | |
| NCT00405964 | Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00405964 | - | Completed | - | - | |
| NCT00805584 | Rhinitis, Allergic, Seasonal | Phase 4 | Completed | - | - |
| NCT00780403 | Allergies | Phase 4 | Completed | - | - |
| NCT00795158 | Urticaria | Phase 3 | Completed | - | - |
| NCT00779636 | Allergic Airway Disease | Phase 4 | Completed | - | - |
| NCT01916980 | - | Completed | - | - | |
| NCT02904304 | Cold | Phase 3 | Not yet recruiting | November 2019 | Brazil ... More >> Allergisa Pesquisa Dermato Cosmética Ltda. Not yet recruiting Campinas, São Paulo, Brazil Contact: Mauro Crippa Jr. *55 19 3789-8615 Less << |
| NCT00794378 | Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00794794 | Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00724698 | Rhinitis|Urticaria | COMPLETED | 2025-12-07 | - | |
| NCT00724698 | Rhinitis|Urticaria | COMPLETED | 2025-12-07 | - | |
| NCT00780403 | - | Completed | - | - | |
| NCT00779116 | - | Completed | - | - | |
| NCT00704769 | - | Completed | - | - | |
| NCT00779116 | Allergies | Phase 4 | Completed | - | - |
| NCT00757562 | Chronic Idiopathic Urticaria ... More >> Atopy Less << | Phase 3 | Completed | - | - |
| NCT00867191 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | - |
| NCT00536380 | Chronic Idiopathic Urticaria | Phase 4 | Completed | - | - |
| NCT00761527 | - | Completed | - | - | |
| NCT00805324 | Rhinitis, Allergic, Seasonal|A... More >>sthma Less << | PHASE3 | COMPLETED | 2025-08-03 | - |
| NCT00789152 | Allergic Rhinitis | Phase 3 | Completed | - | - |
| NCT00761527 | - | Completed | - | - | |
| NCT01506791 | Healthy | Phase 1 | Completed | - | United States, Florida ... More >> SFBC Ft Myers Inc Broadway, Florida, United States, 33901 Less << |
| NCT01373138 | Healthy | Phase 1 | Completed | - | Canada ... More >> SFBC Anapharm Sainte-Foy (Quebec), Canada, G1V 2K8 Less << |
| NCT02646020 | Non-small Cell Lung Cancer | Phase 2 | Unknown | December 2017 | China, Guangdong ... More >> Cancer Center of Sun-Yat Sen University (CCSYSU) GuangZhou, Guangdong, China, 510060 Less << |
| NCT01314339 | Fasting | PHASE1 | COMPLETED | 2025-02-06 | SFBC, Ft. Myers, Inc.,, Ft. My... More >>ers, Florida, 33901, United States Less << |
| NCT00536380 | - | Completed | - | - | |
| NCT01506037 | Healthy | PHASE1 | COMPLETED | 2025-02-06 | SFBC Ft Myers Inc, Broadway, F... More >>lorida, 33901, United States Less << |
| NCT01314352 | Fed | PHASE1 | COMPLETED | 2025-03-06 | SFBC, Ft. Myers, Inc.,, Ft. My... More >>ers, Florida, 33901, United States Less << |
| NCT01506050 | Healthy | PHASE1 | COMPLETED | 2025-02-06 | SFBC Ft Myers Inc, Broadway, F... More >>lorida, 33901, United States Less << |
| NCT00817076 | Dermatitis, Atopic | Phase 3 | Completed | - | - |
| Bio Calculators | ||||
| Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
3.22mL 0.64mL 0.32mL |
16.09mL 3.22mL 1.61mL |
32.17mL 6.43mL 3.22mL |
|
| Dissolving Methods |
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
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