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Chemical Structure| 100643-71-8 Chemical Structure| 100643-71-8

Structure of Desloratadine
CAS No.: 100643-71-8

Chemical Structure| 100643-71-8

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Desloratadine is an antagonist of histamine H1 receptor that is used to treat allergies.

Synonyms: Sch34117; Descarboethoxyloratadine; Aerius

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Product Details of Desloratadine

CAS No. :100643-71-8
Formula : C19H19ClN2
M.W : 310.82
SMILES Code : ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1
Synonyms :
Sch34117; Descarboethoxyloratadine; Aerius
MDL No. :MFCD00871949
InChI Key :JAUOIFJMECXRGI-UHFFFAOYSA-N
Pubchem ID :124087

Safety of Desloratadine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Desloratadine

GPCR

Isoform Comparison

Biological Activity

Target
  • H1 receptor

    Histamine H1 receptor, IC50:51 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
CHO-K1 cells 3.48 μM Evaluate the inhibitory effect of DLT on 5HT2AR Aging Cell. 2021 Jan;20(1):e13286.
HepG2 cells 2-10 μg/ml 48 hours To evaluate the inhibitory effect of desloratadine on HCC cell proliferation, results showed significant reduction in cell viability Signal Transduct Target Ther. 2023 Jan 9;8(1):14
Huh7 cells 2-10 μg/ml 48 hours To evaluate the inhibitory effect of desloratadine on HCC cell proliferation, results showed significant reduction in cell viability Signal Transduct Target Ther. 2023 Jan 9;8(1):14
Hep3B cells 6 μg/ml Inhibited cell proliferation Signal Transduct Target Ther. 2023 Jan 9;8(1):14.
SK-Hep1 cells 6 μg/ml Inhibited cell proliferation Signal Transduct Target Ther. 2023 Jan 9;8(1):14.
HepG2 cells 2-10 μg/ml 48 h Inhibited HCC cell proliferation and induced apoptosis Signal Transduct Target Ther. 2023 Jan 9;8(1):14.
Huh7 cells 2-10 μg/ml 48 h Inhibited HCC cell proliferation and induced apoptosis Signal Transduct Target Ther. 2023 Jan 9;8(1):14.
human small airway epithelial cells (AEC) 16 µM, 32 µM, 64 µM 2 h Desloratadine reduced the SPRBD-induced increases in CHST15 and CHST11 mRNA expression and partially reversed the SPRBD-induced declines in ARSB activity and expression. Signal Transduct Target Ther. 2024 Feb 14;9(1):39.
ACE2 overexpressing HEK293T cells 1, 5, 10, 20 μM 48 h To evaluate the inhibitory effect of Desloratadine on the entry of SARS-CoV-2 pseudotyped virus into cells, results showed that Desloratadine significantly inhibited the viral entry and was more effective than Loratadine Chem Biol Interact. 2021 Apr 1;338:109420.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
APP/PS1 mice Alzheimer's disease model Oral 20 mg/kg/day Once daily for three months DLT ameliorated pathological behavior of APP/PS1 mice by antagonizing 5HT2AR, including improving short-term working memory defect, spatial working memory defect, and learning performance defect. Aging Cell. 2021 Jan;20(1):e13286.
APP/PS1 mice Alzheimer's disease model mice Oral 20 mg/kg/day Once daily for three months Evaluate the ameliorative effect of DLT on pathological behavior of APP/PS1 mice Aging Cell. 2021 Jan;20(1):e13286.
Nude mice HCC xenograft model Oral 15 or 45 mg/kg Once every two days for 2-3 weeks To evaluate the inhibitory effect of desloratadine on HCC tumor growth, results showed significant suppression of tumor growth Signal Transduct Target Ther. 2023 Jan 9;8(1):14
Nude mice Huh7 and HepG2 cells-derived xenograft models Oral 15 or 45 mg/kg Once every two days for 2-3 weeks Significantly suppressed tumor growth Signal Transduct Target Ther. 2023 Jan 9;8(1):14.

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00884325 - Completed - -
NCT03724240 Hay Fever Phase 3 Not yet recruiting December 2019 -
NCT03517930 Clinical Pharmacology Phase 1 Completed - United States, New Jersey ... More >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Less <<
NCT00866788 Chronic Idiopathic Urticaria Phase 2 Completed - -
NCT00866788 - Completed - -
NCT00633919 - Completed - -
NCT00310466 Allergy Phase 3 Completed - Germany ... More >> Charité Klinik für Dermatologie, Venerologie und Allergologie Berlin, Germany, D-10117 Less <<
NCT00633919 Allergy Phase 2 Phase 3 Completed - Spain ... More >> Fernando Rodríguez Santander, Cantabria, Spain Less <<
NCT00310466 - Completed - -
NCT01940393 Urticaria Phase 4 Completed - Colombia ... More >> Medellin Medellin, Antioquia, Colombia Less <<
NCT02593747 Histamine H1 Antagonists, Non-... More >>Sedating Less << Phase 1 Completed - Germany ... More >> Neu-Ulm, Bayern, Germany, 89231 Less <<
NCT00884325 Atopic Dermatitis ... More >> Pruritus Less << Phase 4 Completed - United States, Kentucky ... More >> DermResearch, PLLC Louisville, Kentucky, United States, 40217 Less <<
NCT00730912 - Completed - -
NCT03517943 Clinical Pharmacology Phase 1 Completed - United States, New Jersey ... More >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Less <<
NCT01740284 Allergic Rhinoconjunctivitis Phase 3 Completed - Germany ... More >> Zentrum für Rhinologie und Allergologie Wiesbaden, Germany, 65183 Less <<
NCT00730912 Perennial Allergic Rhinitis Phase 4 Completed - -
NCT00160537 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT01985789 Asthma Phase 4 Completed - Canada, Saskatchewan ... More >> University of Saskatchewan Saskatoon, Saskatchewan, Canada, S7N 0W8 Less <<
NCT00521170 Allergy Phase 1 Completed - France ... More >> Illkirch, France Strasbourg, France Less <<
NCT00160589 Rhinitis, Allergic, Perennial Phase 4 Completed - -
NCT03751111 Chronic Pruritus Phase 1 Phase 2 Not yet recruiting February 1, 2019 -
NCT00967967 Asthma Rhinit... More >>is Less << Not Applicable Suspended(Awaiting results fro... More >>m sub analysis to decide if study continuesé) Less << September 2014 Canada, Quebec ... More >> Institut universitaire de cardiologie et de pneumologie de Québec Québec, Quebec, Canada, G1V 4G5 Less <<
NCT01400828 Seasonal Allergic Rhinitis Phase 3 Completed - Korea, Republic of ... More >> Yonsei University college of Medicine, Gangnam Severance Hospital Seoul, Korea, Republic of Less <<
NCT02507635 Allergic Rhinitis Phase 4 Completed - -
NCT00264303 Chronic Idiopathic Urticaria Phase 4 Completed - -
NCT00346606 Chronic Idiopathic Urticaria ... More >> Urticaria Less << Phase 4 Unknown - Taiwan ... More >> Department of Dermatology National Taiwan University Hospital Recruiting Taipei, Taiwan Contact: Jia-Yu Chu    +886-2-23123456 ext 5734       Principal Investigator: Jia-Yu Chu Less <<
NCT00636870 Allergic Rhinitis Phase 4 Completed - United States, New Jersey ... More >> Sanofi-Aventis Bridgewater, New Jersey, United States, 08807 Less <<
NCT00637585 Allergic Rhinitis Phase 4 Completed - United States, New Jersey ... More >> Sanofi-Aventis Bridgewater, New Jersey, United States, 08807 Less <<
NCT01529229 Allergic Rhinitis Phase 3 Completed - -
NCT00424580 Asthma Not Applicable Completed - Canada, Saskatchewan ... More >> Room 346 Ellis Hall Saskatoon, Saskatchewan, Canada, S7N 0W8 Less <<
NCT01720485 Allergic Rhinitis Phase 3 Unknown March 2014 Brazil ... More >> IMA - Instituto de Pesquisa Clínica e Medicina Avançada Not yet recruiting São Paulo, Brazil Contact: Fabio M Castro, MD    55 11 38639156    daniela.fakih@imabrasil.com    Principal Investigator: Fabio M Castro, MD Less <<
NCT00264303 - Completed - -
NCT01108783 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT00751218 Urticaria Phase 4 Completed - -
NCT00723736 Rhinitis|Urticaria COMPLETED 2025-06-08 -
NCT00862225 Seasonal Allergic Rhinitis Phase 2 Completed - Germany ... More >> Dept. of Otorhinolaryngology and Head and Neck Surgery Dusseldorf, Germany Less <<
NCT00723736 Rhinitis|Urticaria COMPLETED 2025-06-08 -
NCT00311844 Conjunctivitis, Allergic Phase 4 Completed - -
NCT01916967 Urticaria Phase 3 Completed - -
NCT00751166 Urticaria Phase 4 Terminated(Study could not be ... More >>re-supplied with study medication in a timely manner.) Less << - -
NCT01916967 - Completed - -
NCT00816972 Post-nasal Drip ... More >> Seasonal Allergic Rhinitis Rhinorrhea Less << Phase 2 Completed - -
NCT01529242 Cutaneous Hypersensitivity Phase 3 Terminated(By sponsor decision... More >> due to difficulty of recruitment) Less << - Brazil ... More >> Alergoalpha São Paulo, SP, Brazil Allergisa Campinas, São Paulo, Brazil Hospital Nipo Brasileiro São Paulo, Brazil Less <<
NCT00600847 Acquired Cold Urticaria Phase 4 Completed - Germany ... More >> Allergie-Centrum-Charité Berlin Berlin, Germany, 10117 Less <<
NCT00359138 Hypersensitivity Phase 4 Completed - -
NCT01918033 - Completed - -
NCT00359138 - Completed - -
NCT02320396 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT00783211 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT01918033 Perennial Allergic Rhinitis Phase 3 Completed - -
NCT00795522 Urticaria PHASE4 COMPLETED 2025-03-05 -
NCT00783133 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT00794248 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT00794768 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT00783354 Urticaria Chr... More >>onic Idiopathic Urticaria Less << Phase 4 Completed - -
NCT00794495 Seasonal Allergic Rhinitis ... More >> Perennial Allergic Rhinitis Less << Phase 4 Completed - -
NCT00794599 Seasonal Allergic Rhinitis ... More >> Perennial Allergic Rhinitis Less << Phase 4 Completed - -
NCT02320396 - Completed - -
NCT01444196 Urticaria PHASE4 COMPLETED 2025-05-10 Department of Dermatology, Ven... More >>erology and Allergology, Berlin, 10117, Germany Less <<
NCT00598611 Chronic Urticaria Phase 3 Completed - Germany ... More >> Allergie-Centrum-Charite Berlin, Germany, 10117 Less <<
NCT01916980 Eczema Dermat... More >>itis Dermal Pruritus Less << Phase 3 Completed - -
NCT00783146 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT00406783 Rhinitis, Allergic, Seasonal ... More >> Rhinitis, Allergic, Perennial Less << Phase 3 Completed - -
NCT00406783 - Completed - -
NCT00794846 Seasonal Allergic Rhinitis ... More >> Perennial Allergic Rhinitis Less << Phase 4 Completed - -
NCT00704769 - Completed - -
NCT00405964 Allergic Rhinitis Phase 3 Completed - -
NCT00405964 - Completed - -
NCT00805584 Rhinitis, Allergic, Seasonal Phase 4 Completed - -
NCT00780403 Allergies Phase 4 Completed - -
NCT00795158 Urticaria Phase 3 Completed - -
NCT00779636 Allergic Airway Disease Phase 4 Completed - -
NCT01916980 - Completed - -
NCT02904304 Cold Phase 3 Not yet recruiting November 2019 Brazil ... More >> Allergisa Pesquisa Dermato Cosmética Ltda. Not yet recruiting Campinas, São Paulo, Brazil Contact: Mauro Crippa Jr.    *55 19 3789-8615 Less <<
NCT00794378 Allergic Rhinitis Phase 3 Completed - -
NCT00794794 Allergic Rhinitis Phase 3 Completed - -
NCT00724698 Rhinitis|Urticaria COMPLETED 2025-12-07 -
NCT00724698 Rhinitis|Urticaria COMPLETED 2025-12-07 -
NCT00780403 - Completed - -
NCT00779116 - Completed - -
NCT00704769 - Completed - -
NCT00779116 Allergies Phase 4 Completed - -
NCT00757562 Chronic Idiopathic Urticaria ... More >> Atopy Less << Phase 3 Completed - -
NCT00867191 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT00536380 Chronic Idiopathic Urticaria Phase 4 Completed - -
NCT00761527 - Completed - -
NCT00805324 Rhinitis, Allergic, Seasonal|A... More >>sthma Less << PHASE3 COMPLETED 2025-08-03 -
NCT00789152 Allergic Rhinitis Phase 3 Completed - -
NCT00761527 - Completed - -
NCT01506791 Healthy Phase 1 Completed - United States, Florida ... More >> SFBC Ft Myers Inc Broadway, Florida, United States, 33901 Less <<
NCT01373138 Healthy Phase 1 Completed - Canada ... More >> SFBC Anapharm Sainte-Foy (Quebec), Canada, G1V 2K8 Less <<
NCT02646020 Non-small Cell Lung Cancer Phase 2 Unknown December 2017 China, Guangdong ... More >> Cancer Center of Sun-Yat Sen University (CCSYSU) GuangZhou, Guangdong, China, 510060 Less <<
NCT01314339 Fasting PHASE1 COMPLETED 2025-02-06 SFBC, Ft. Myers, Inc.,, Ft. My... More >>ers, Florida, 33901, United States Less <<
NCT00536380 - Completed - -
NCT01506037 Healthy PHASE1 COMPLETED 2025-02-06 SFBC Ft Myers Inc, Broadway, F... More >>lorida, 33901, United States Less <<
NCT01314352 Fed PHASE1 COMPLETED 2025-03-06 SFBC, Ft. Myers, Inc.,, Ft. My... More >>ers, Florida, 33901, United States Less <<
NCT01506050 Healthy PHASE1 COMPLETED 2025-02-06 SFBC Ft Myers Inc, Broadway, F... More >>lorida, 33901, United States Less <<
NCT00817076 Dermatitis, Atopic Phase 3 Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.09mL

3.22mL

1.61mL

32.17mL

6.43mL

3.22mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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