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Chemical Structure| 937782-05-3 Chemical Structure| 937782-05-3

Structure of Difamilast
CAS No.: 937782-05-3

Chemical Structure| 937782-05-3

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Difamilast (OPA-15406) is a topical, selective nonsteroidal phosphodiesterase 4 (PDE4) inhibitor with particularly effective inhibition of subtype B (IC50 = 11.2 nM), used for studying mild-to-moderate atopic dermatitis (AD).

Synonyms: OPA-15406

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Product Details of Difamilast

CAS No. :937782-05-3
Formula : C23H24F2N2O5
M.W : 446.44
SMILES Code : O=C(NCC1=COC(C2=CC=C(OC(F)F)C(OC(C)C)=C2)=N1)C3=CC=CC=C3OCC
Synonyms :
OPA-15406
MDL No. :N/A

Safety of Difamilast

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Normal human epidermal keratinocytes (NHEKs) 5 μM 24 h To investigate the effect of the supernatant from difamilast-treated NHEKs on IL-33-induced signaling Int J Mol Sci. 2024 Jul 19;25(14):7910
Normal human epidermal keratinocytes (NHEKs) 5 µM 3, 6, or 24 h Difamilast treatment increased mRNA and protein levels of sST2 without affecting ST2L expression. Int J Mol Sci. 2024 Jul 19;25(14):7910

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05372653 Atopic Dermatitis (AD) PHASE3 COMPLETED 2023-11-29 Sotobo Children's Clinic, Isum... More >>i, Japan Less <<
NCT05571943 Atopic Dermatitis PHASE3 COMPLETED 2024-07-31 Qualmedica Research, LLC, Birm... More >>ingham, Alabama, 35205, United States|AllerVie Health, Birmingham, Alabama, 35244, United States|Elite Clinical Studies, LLC, Phoenix, Arizona, 85018, United States|NEA Baptist Clinic-Dermatology, Jonesboro, Arkansas, 72405, United States|First OC Dermatology, Fountain Valley, California, 92708, United States|Center for Dermatology Clinical Research, Inc., Fremont, California, 94538, United States|Southern CA Dermatology Skin and Laser, Laguna Niguel, California, 92677, United States|Antelope Valley Clinical Trials, Lancaster, California, 93534, United States|Dermatology Research Associates, Los Angeles, California, 90045, United States|Clinical Trials Research Institute, Thousand Oaks, California, 91320, United States|Clarity Dermatology, LLC, Castle Rock, Colorado, 80109, United States|IMMUNOe Research Centers, Centennial, Colorado, 80112, United States|TrueBlue Clinical Research, Brandon, Florida, 33511, United States|Annexus Dermatology & Aethestics, DeLand, Florida, 32720, United States|Accel Research - Edgewater Clinical Research Unit, Edgewater, Florida, 32132, United States|Skin Care Research, Hollywood, Florida, 33021, United States|Kirsch Dermatology, Naples, Florida, 34102, United States|Tory Sullivan, MD PA, North Miami Beach, Florida, 33162, United States|Pure Skin Dermatology & Aesthetics, Orlando, Florida, 32819, United States|Nona Pediatrics, Orlando, Florida, 32829, United States|Accel Research - Ormond Clinical Research Unit, Ormond Beach, Florida, 32174, United States|Olympian Clinical Research, Saint Petersburg, Florida, 33706, United States|Solaris Clinical Research, Meridian, Idaho, 83646, United States|Arlington Dermatology, Rolling Meadows, Illinois, 60008, United States|DS Research, Clarksville, Indiana, 47129, United States|Qualmedica Research, LLC, Evansville, Indiana, 47715, United States|Dawes Fretzin Clinical Research Group, LLC, Indianapolis, Indiana, 46250, United States|The Indiana Clinical Trials Center, Plainfield, Indiana, 46168, United States|South Bend Clinic, South Bend, Indiana, 46617, United States|Options Research Group, LLC, West Lafayette, Indiana, 47906, United States|Meridian Clinical Research, Overland Park, Kansas, 66210, United States|Qualmedica Research, LLC, Bowling Green, Kentucky, 42101, United States|DS Research, Louisville, Kentucky, 40241, United States|Clinical Trials Management, LLC, Covington, Louisiana, 70433, United States|Avant Research Associates, LLC, Crowley, Louisiana, 70526, United States|Clinical Trials Management, LLC, Metairie, Louisiana, 70006, United States|DermAssociates, LLC, Rockville, Maryland, 20850, United States|Metro Boston Clinical Partners, Brighton, Massachusetts, 02135, United States|Oakland Hills Dermatology, PC, Auburn Hills, Michigan, 48326, United States|Michigan Dermatology Institute, Waterford, Michigan, 48328, United States|Minnesota Clinical Study Center, New Brighton, Minnesota, 55112, United States|Cleaver Dermatology, Kirksville, Missouri, 63501, United States|Vivida Dermatology, Las Vegas, Nevada, 89119, United States|Forest Hills Dermatology Group, Kew Gardens, New York, 11415, United States|Bexley Dermatology Research, Bexley, Ohio, 43209, United States|Optima Research, Boardman, Ohio, 44512, United States|Remington-Davis, Inc., Columbus, Ohio, 43215, United States|Optimed Research, Columbus, Ohio, 43235, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Dermatology Associates of Plymouth Meeting, Plymouth Meeting, Pennsylvania, 19462, United States|Peak Research, LLC, Upper Saint Clair, Pennsylvania, 15241, United States|Palmetto Clinical Trial Services, LLC, Anderson, South Carolina, 29621, United States|Coastal Pediatric Research, Charleston, South Carolina, 29414, United States|International Clinical Research - Tennessee, LLC, Murfreesboro, Tennessee, 37130, United States|Arlington Research Center, Inc., Arlington, Texas, 76011, United States|Derm Research, Austin, Texas, 78759, United States|J&S Studies, College Station, Texas, 77845, United States|North Texas Center for Clinical Research, Frisco, Texas, 75034, United States|Center for Clinical Studies, Ltd, LLP, Houston, Texas, 77004, United States|Research Your Health, Plano, Texas, 75093, United States|Houston Center for Clinical Research, Sugar Land, Texas, 77479, United States|Center for Clinical Studies, Webster, Texas, 77598, United States|Premier Clinical Research, LLC, Spokane, Washington, 99202, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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