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Chemical Structure| 436-32-8 Chemical Structure| 436-32-8

Structure of Diffractaic acid
CAS No.: 436-32-8

Chemical Structure| 436-32-8

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Diffractaic acid is a lichen metabolite that has been found in P. magellanica and has diverse biological activities{{22628260}}{{19683421}}{{16920514}}{{7753915}}. It is cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively){{22628260}}. Diffractaic acid inhibits growth of M. tuberculosis (MIC = 41.7 μM){{19683421}}. In vivo, diffractaic acid (25 - 200 mg/kg) reduces neutrophil infiltration, lipid peroxidation, myeloperoxidase (MPx) activity, and the number of gastric lesions as well as reverses decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities induced by indomethacin in rat gastric mucosa{{16920514}}. Diffractaic acid also has analgesic activity, reducing acetic acid-induced writhing and increasing the pressure pain threshold in mice{{7753915}}.

Synonyms: NSC 5901; NSC 685595

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Product Details of Diffractaic acid

CAS No. :436-32-8
Formula : C20H22O7
M.W : 374.38
SMILES Code : O=C(OC1=CC(C)=C(C(O)=O)C(O)=C1C)C2=C(C)C=C(OC)C(C)=C2OC
Synonyms :
NSC 5901; NSC 685595
MDL No. :MFCD01684770

Safety of Diffractaic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.36mL

2.67mL

1.34mL

26.71mL

5.34mL

2.67mL

 

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