Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 19408-84-5 Chemical Structure| 19408-84-5

Structure of Dihydrocapsaicin
CAS No.: 19408-84-5

Chemical Structure| 19408-84-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Dihydrocapsaicin, a natural product isolated and purified from the fruits of Capsicum annuum L..

Synonyms: DHC

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Dihydrocapsaicin

CAS No. :19408-84-5
Formula : C18H29NO3
M.W : 307.43
SMILES Code : COC1=C(O)C=CC(CNC(=O)CCCCCCC(C)C)=C1
Synonyms :
DHC
MDL No. :MFCD00057794
InChI Key :XJQPQKLURWNAAH-UHFFFAOYSA-N
Pubchem ID :107982

Safety of Dihydrocapsaicin

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P305+P351+P338
Class:6.1
UN#:3462
Packing Group:

Related Pathways of Dihydrocapsaicin

PI3K-AKT
pyroptosis

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human lens epithelial cells (HLE) 10 µM 5 days To study the protective effect of NDHC on oxidative stress in HLE cells under high glucose conditions, results showed NDHC significantly reduced ROS levels. Int J Mol Sci. 2022 Nov 12;23(22):13960

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Male Sprague-Dawley rats Middle cerebral artery occlusion (MCAO) model Intraperitoneal injection 0.5 mg/kg (low dose) and 1.5 mg/kg (high dose) Single administration, lasting for 3 hours To evaluate the neuroprotective effects of dihydrocapsaicin (DHC) combined with physical cooling (ice pad) in ischemic stroke. Results showed that combination therapy significantly reduced infarct volume, neurological deficits, and apoptotic cell death, and improved brain oxidative metabolism. Aging Dis. 2018 Aug 1;9(4):578-589
Rats Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats Intravenous injection 30 μg/kg Single dose To evaluate the effect of TRPV1 activation on blood pressure, showing that DHC induced the greatest depressor effect in DRHS rats Hypertension. 2010 Apr;55(4):1018-25
Sprague Dawley rats Middle cerebral artery occlusion (MCAO) model Intraperitoneal injection 0.5 mg/kg Single dose Dihydrocapsaicin (DHC) in combination with chlorpromazine and promethazine (C + P) induced faster, longer, and deeper hypothermia, significantly improving infarct volume, neurological deficits, NOX activity and its subunit gp91, ROS, cell death, glucose, and lactate levels, while raising ATP levels. Biomolecules. 2022 Jun 19;12(6):851
Mice Conscious unrestrained young and aged male mice Subcutaneous injection 2–4 mg/kg (s.c.) Single or continuous infusion, lasting 6 hours To investigate the hypothermic effect of dihydrocapsaicin (DHC) through TRPV1 channel activation in mice. Results showed that DHC produced a dose-dependent (2–4 mg/kg, s.c.) drop in core temperature (T core). A loading dose followed by continuous infusion of DHC produced a rapid and prolonged (>6 hrs) drop of T core within the therapeutic range (32–34 °C). The hypothermic effect of DHC was augmented in aged mice and was not desensitized with repeated administration. Crit Care Med. 2014 May;42(5):e355-63

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.33mL

16.26mL

3.25mL

1.63mL

32.53mL

6.51mL

3.25mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories