Home Cart Sign in  
Chemical Structure| 19057-60-4 Chemical Structure| 19057-60-4

Structure of Dioscin
CAS No.: 19057-60-4

Chemical Structure| 19057-60-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Dioscin, a natural product isolated and purified from the rhizome of Dioscorea Zingiberensis C.H.Wright, is a potent ITGA5 inhibitor, showing potent anti-cancer effect against a variety of tumor cell lines.

Synonyms: CCRIS 4123; Collettiside III; Saponin

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Dioscin

CAS No. :19057-60-4
Formula : C45H72O16
M.W : 869.04
SMILES Code : C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@H](O[C@@]8([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O8)O)O)[C@@H](CO)O7)O)O[C@@]9([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O9)O)O)CC6)=CC5)C)([H])CC2
Synonyms :
CCRIS 4123; Collettiside III; Saponin
MDL No. :MFCD02094174
InChI Key :VNONINPVFQTJOC-ZGXDEBHDSA-N
Pubchem ID :119245

Safety of Dioscin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Dioscin

cytoskeleton

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
U2OS and 143B cells 2.5 µM 24 hours Dioscin induced G2/M phase arrest Cell Death Dis. 2018 Mar 1;9(3):343.
Human periodontal ligament stem cells (hPDLSCs) 1 μg/mL and 3 μg/mL 1 day and 3 days Dioscin promoted osteogenic differentiation of hPDLSCs under LPS-induced inflammatory conditions, increasing the expression of osteogenic markers and the formation of mineralized nodules. Int J Biol Sci. 2024 Jan 27;20(4):1375-1388.
HT29 cells 2 µM 12 hours Screening of a natural product library revealed that Dioscin significantly inhibited glycolysis in HT29 cells. EBioMedicine. 2020 Jan;51:102570.
H9C2 cells 50, 100, 200 ng/mL 24 hours To investigate the protective effect of Dioscin against DOX-induced H9C2 cell injury, the results showed that Dioscin significantly increased cell viability and improved cell morphology Redox Biol. 2018 Jun;16:189-198.
RAW264.7 cells 37.5, 75, 150, 300, 600, 1200, 2400 ng/mL 24 hours To evaluate the effect of Dioscin on the viability of RAW264.7 cells, results showed that Dioscin had no significant effect on cell viability within the concentration range. Theranostics. 2017 Sep 26;7(17):4255-4275.
NIH-3T3 cells 125, 250, 500, 1000, 2000, 4000, 8000 ng/mL 24 hours To evaluate the effect of Dioscin on the viability of NIH-3T3 cells, results showed that Dioscin had no significant effect on cell viability within the concentration range. Theranostics. 2017 Sep 26;7(17):4255-4275.
SMMC7721 cells 1.4, 2.9, 5.8 µM 24 hours Dioscin significantly inhibited the proliferation, migration, and invasion of SMMC7721 cells, and induced apoptosis, autophagy, and DNA damage. Br J Pharmacol. 2019 Apr;176(7):919-937.
HepG2 cells 1.4, 2.9, 5.8 µM 24 hours Dioscin significantly inhibited the proliferation, migration, and invasion of HepG2 cells, and induced apoptosis, autophagy, and DNA damage. Br J Pharmacol. 2019 Apr;176(7):919-937.
SK-MES-1 0, 1.25, 2.5, 5, 10 µM 24 hours and 48 hours Dioscin significantly inhibited the proliferation of lung SCC cells, with an IC50 value of 2.05 μM at 48 h. Int J Biol Sci. 2020 Sep 2;16(15):2883-2894.
NCI-H520 0, 1.25, 2.5, 5, 10 µM 24 hours and 48 hours Dioscin significantly inhibited the proliferation of lung SCC cells, with an IC50 value of 4.59 μM at 48 h. Int J Biol Sci. 2020 Sep 2;16(15):2883-2894.
HBE 0, 1.25, 2.5, 5, 10 µM 24 hours and 48 hours Dioscin had a weaker inhibitory effect on HBE cells, with an IC50 value of 8.47 μM at 48 h. Int J Biol Sci. 2020 Sep 2;16(15):2883-2894.
MC3T3-E1 cells 0.25 μg/ml, 0.5 μg/ml, 1.0 μg/ml 24 hours, 48 hours, 72 hours Dioscin significantly promoted the proliferation of MC3T3-E1 cells in a dose-dependent manner at 48 h and 72 h. J Biomed Sci. 2014 Apr 17;21(1):30.
MG-63 cells 0.25 μg/ml, 0.5 μg/ml, 1.0 μg/ml 24 hours, 48 hours, 72 hours Dioscin significantly promoted the proliferation of MG-63 cells in a dose-dependent manner at 48 h and 72 h. J Biomed Sci. 2014 Apr 17;21(1):30.
NOZ cells 0, 1, 2, 4, 6, 8 µM 24hours, 48 hours, 72 hours To evaluate the inhibitory effect of Dioscin on NOZ cell proliferation Int J Biol Sci. 2017 Jun 1;13(6):782-793.
SGC996 cells 0, 1, 2, 4, 6, 8 µM 24hours, 48 hours, 72 hours To evaluate the inhibitory effect of Dioscin on SGC996 cell proliferation Int J Biol Sci. 2017 Jun 1;13(6):782-793.
293T cells 0, 1, 2, 4, 6, 8 µM 24hours, 48 hours, 72 hours To evaluate the effect of Dioscin on 293T cells Int J Biol Sci. 2017 Jun 1;13(6):782-793.
NIH-3T3 cells 1000, 500, 250 ng/mL 30 minutes To evaluate the effect of Dioscin on the TGF-β/Smad3 signaling pathway in NIH-3T3 cells, results showed that Dioscin significantly inhibited the phosphorylation of Smad3. Theranostics. 2017 Sep 26;7(17):4255-4275.
Bone marrow-derived macrophages (BMDMs) 1 μg/mL and 3 μg/mL 4 hours Dioscin inhibited the LPS-induced elevation of Il1β, Il6, Tnfα, and Nlrp3 mRNA expression and reduced the secretion of IL-6 and TNF-α. Int J Biol Sci. 2024 Jan 27;20(4):1375-1388.
PC9GR cells 2.1 µM 48 hours Dioscin inhibits cell viability and induces apoptosis in PC9GR cells Int J Biol Sci. 2018 Jan 11;14(1):47-56.
H1650 cells 1.7 µM 48 hours Dioscin inhibits cell viability and induces apoptosis in H1650 cells Int J Biol Sci. 2018 Jan 11;14(1):47-56.
H1975 cells 4.3 µM 48 hours Dioscin inhibits cell viability and induces apoptosis in H1975 cells Int J Biol Sci. 2018 Jan 11;14(1):47-56.
CL97 cells 4.1 µM 48 hours Dioscin inhibits cell viability and induces apoptosis in CL97 cells Int J Biol Sci. 2018 Jan 11;14(1):47-56.
U2OS and 143B cells 2.5 µM 48 hours Dioscin significantly increased the proportion of apoptotic cells Cell Death Dis. 2018 Mar 1;9(3):343.
RAW264.7 cells 300, 150, 75 ng/mL 6 hours To evaluate the effect of Dioscin on the secretion of pro-inflammatory cytokines in RAW264.7 cells, results showed that Dioscin significantly inhibited the secretion of IL-1β, IL-6, TNF-α, and MCP-1. Theranostics. 2017 Sep 26;7(17):4255-4275.
MH-S cells 200 nM, 400 nM, 800 nM Dioscin treatment reduced CS-induced apoptosis in MH-S cells and promoted autophagy. Theranostics. 2019 Mar 7;9(7):1878-1892.
Human Umbilical Vein Endothelial Cells (HUVECs) 1.25 mg/L and 5 mg/L Dioscin promoted endothelial cell proliferation, migration, and tube formation under hypoxic conditions, indicating its pro-angiogenic effects. Aging Cell. 2021 Jul;20(7):e13392.
MG-63 cells 0.25 μg/ml, 0.5 μg/ml, 1.0 μg/ml 24 h, 48 h, 72 h Promoted MG-63 cell proliferation and differentiation, dose-dependently increased ALP activity, upregulated ER-α, ER-β, and β-catenin protein expression J Biomed Sci. 2014 Apr 17;21(1):30.
MC3T3-E1 cells 0.25 μg/ml, 0.5 μg/ml, 1.0 μg/ml 24 h, 48 h, 72 h Promoted MC3T3-E1 cell proliferation and differentiation, dose-dependently increased ALP activity and mineralization nodule formation, upregulated ER-α, ER-β, β-catenin, and Bcl-2 protein expression J Biomed Sci. 2014 Apr 17;21(1):30.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice NOZ cell xenograft model Injection 0, 5, 10 mg/kg Every 3 days for 25 days To evaluate the inhibitory effect of Dioscin on NOZ cell xenograft tumors Int J Biol Sci. 2017 Jun 1;13(6):782-793.
Nude mice Xenograft model Intraperitoneal injection 10 mg/kg Every two days, until the end of the experiment Dioscin delayed in vivo tumor growth, promoted Skp2 ubiquitination, and inhibited Skp2 expression. EBioMedicine. 2020 Jan;51:102570.
C57BL/6J mice Ligation-induced periodontitis model Gingival injection 10 mg/kg Once every other day for 2 weeks Dioscin significantly reduced alveolar bone loss in ligation-induced periodontitis mice and suppressed the inflammatory response in periodontal tissues. Int J Biol Sci. 2024 Jan 27;20(4):1375-1388.
Rats Diethylnitrosamine-induced primary liver cancer model Oral 15, 30, 60 mg/kg Once daily for 18 weeks Dioscin significantly inhibited diethylnitrosamine-induced primary liver cancer in rats, improved body weight changes, and restored serum levels of AFP, ALT, AST, γ-GT, ALP, and Ki67. Br J Pharmacol. 2019 Apr;176(7):919-937.
C57BL/6 mice Silicosis model Oral 20, 40, 80 mg/kg Once daily for 56 days To evaluate the effect of Dioscin on pulmonary fibrosis in a silicosis mouse model, results showed that Dioscin significantly reduced collagen deposition and alleviated pulmonary fibrosis. Theranostics. 2017 Sep 26;7(17):4255-4275.
C57BL/6 mice Myocardial Infarction Model Intragastric administration 40 µg/g Once daily for 2 weeks Dioscin significantly improved cardiac function in mice with myocardial infarction, reduced cardiac fibrosis and apoptosis, and alleviated cardiac damage by promoting angiogenesis. Aging Cell. 2021 Jul;20(7):e13392.
Nude mice Osteosarcoma xenograft model Oral 60 mg/kg Once daily until the end of the experiment Dioscin significantly inhibited the growth of osteosarcoma xenografts without obvious side effects Cell Death Dis. 2018 Mar 1;9(3):343.
BALB/c-Nude mice NCI-H520 xenograft model Oral 80 mg/kg/day Once daily for 12 days Dioscin significantly inhibited the growth of NCI-H520 xenograft tumors, with a significant reduction in tumor volume and weight, and induced tumor cell apoptosis. Int J Biol Sci. 2020 Sep 2;16(15):2883-2894.
Rats DOX-induced myocardial injury model Oral 60, 30, 15 mg/kg Once daily for seven consecutive days To investigate the protective effect of Dioscin against DOX-induced myocardial injury, the results showed that Dioscin significantly improved ECG changes, reduced serum CK and LDH levels, and improved myocardial histopathological changes Redox Biol. 2018 Jun;16:189-198.
Mice DOX-induced myocardial injury model Oral 80, 40, 20 mg/kg Once daily for seven consecutive days To investigate the protective effect of Dioscin against DOX-induced myocardial injury, the results showed that Dioscin significantly improved ECG changes, reduced serum CK and LDH levels, and improved myocardial histopathological changes Redox Biol. 2018 Jun;16:189-198.
C57BL/6 mice Silicosis model Oral gavage 80, 40, 20 mg/kg Once daily for 56 consecutive days To investigate the protective effect of dioscin on pulmonary fibrosis in a silicosis mouse model. Results showed that dioscin reduced collagen deposition, decreased the secretion of pro-inflammatory and pro-fibrotic cytokines, and inhibited the TGF-β/Smad3 signaling pathway. Theranostics. 2017 Sep 26;7(17):4255-4275

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.15mL

0.23mL

0.12mL

5.75mL

1.15mL

0.58mL

11.51mL

2.30mL

1.15mL

References

 

Historical Records

Categories