Dioscin (Collettiside III) | Anticancer Agent

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CAS No. :	19057-60-4
Formula :	C₄₅H₇₂O₁₆
M.W :	869.04
SMILES Code :	C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@H](O[C@@]8([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O8)O)O)[C@@H](CO)O7)O)O[C@@]9([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O9)O)O)CC6)=CC5)C)([H])CC2
Synonyms :	CCRIS 4123; Collettiside III; Saponin
MDL No. :	MFCD02094174
InChI Key :	VNONINPVFQTJOC-ZGXDEBHDSA-N
Pubchem ID :	119245

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P280-P305+P351+P338

Human periodontal ligament stem cells (hPDLSCs)	1 μg/mL and 3 μg/mL	1 day and 3 days	Dioscin promoted osteogenic differentiation of hPDLSCs under LPS-induced inflammatory conditions, increasing the expression of osteogenic markers and the formation of mineralized nodules.	PMC10878154
HT29 cells	2 μM	12 hours	Screening of a natural product library revealed that Dioscin significantly inhibited glycolysis in HT29 cells.	PMC7000337
SK-MES-1	0, 1.25, 2.5, 5, 10 μM	24 h and 48 h	Dioscin significantly inhibited the proliferation of lung SCC cells, with an IC50 value of 2.05 μM at 48 h.	PMC7545707
NCI-H520	0, 1.25, 2.5, 5, 10 μM	24 h and 48 h	Dioscin significantly inhibited the proliferation of lung SCC cells, with an IC50 value of 4.59 μM at 48 h.	PMC7545707
HBE	0, 1.25, 2.5, 5, 10 μM	24 h and 48 h	Dioscin had a weaker inhibitory effect on HBE cells, with an IC50 value of 8.47 μM at 48 h.	PMC7545707
MC3T3-E1 cells	0.25 μg/ml, 0.5 μg/ml, 1.0 μg/ml	24 h, 48 h, 72 h	Dioscin significantly promoted the proliferation of MC3T3-E1 cells in a dose-dependent manner at 48 h and 72 h.	PMC4014146
MG-63 cells	0.25 μg/ml, 0.5 μg/ml, 1.0 μg/ml	24 h, 48 h, 72 h	Dioscin significantly promoted the proliferation of MG-63 cells in a dose-dependent manner at 48 h and 72 h.	PMC4014146
H9C2 cells	50, 100, 200 ng/mL	24 hours	To investigate the protective effect of Dioscin against DOX-induced H9C2 cell injury, the results showed that Dioscin significantly increased cell viability and improved cell morphology	PMC5953242
RAW264.7 cells	37.5, 75, 150, 300, 600, 1200, 2400 ng/mL	24 hours	To evaluate the effect of Dioscin on the viability of RAW264.7 cells, results showed that Dioscin had no significant effect on cell viability within the concentration range.	PMC5695011
NIH-3T3 cells	125, 250, 500, 1000, 2000, 4000, 8000 ng/mL	24 hours	To evaluate the effect of Dioscin on the viability of NIH-3T3 cells, results showed that Dioscin had no significant effect on cell viability within the concentration range.	PMC5695011
U2OS and 143B cells	2.5 μM	24 hours	Dioscin induced G2/M phase arrest	PMC5832770
SMMC7721 cells	1.4, 2.9, 5.8 μM	24 hours	Dioscin significantly inhibited the proliferation, migration, and invasion of SMMC7721 cells, and induced apoptosis, autophagy, and DNA damage.	PMC6433650
HepG2 cells	1.4, 2.9, 5.8 μM	24 hours	Dioscin significantly inhibited the proliferation, migration, and invasion of HepG2 cells, and induced apoptosis, autophagy, and DNA damage.	PMC6433650
NOZ cells	0, 1, 2, 4, 6, 8 μM	24h, 48h, 72h	To evaluate the inhibitory effect of Dioscin on NOZ cell proliferation	PMC5485633
SGC996 cells	0, 1, 2, 4, 6, 8 μM	24h, 48h, 72h	To evaluate the inhibitory effect of Dioscin on SGC996 cell proliferation	PMC5485633
293T cells	0, 1, 2, 4, 6, 8 μM	24h, 48h, 72h	To evaluate the effect of Dioscin on 293T cells	PMC5485633
NIH-3T3 cells	1000, 500, 250 ng/mL	30 minutes	To evaluate the effect of Dioscin on the TGF-β/Smad3 signaling pathway in NIH-3T3 cells, results showed that Dioscin significantly inhibited the phosphorylation of Smad3.	PMC5695011
Bone marrow-derived macrophages (BMDMs)	1 μg/mL and 3 μg/mL	4 hours	Dioscin inhibited the LPS-induced elevation of Il1β, Il6, Tnfα, and Nlrp3 mRNA expression and reduced the secretion of IL-6 and TNF-α.	PMC10878154
PC9GR cells	2.1μM	48 hours	Dioscin inhibits cell viability and induces apoptosis in PC9GR cells	PMC5821048
H1650 cells	1.7μM	48 hours	Dioscin inhibits cell viability and induces apoptosis in H1650 cells	PMC5821048
H1975 cells	4.3μM	48 hours	Dioscin inhibits cell viability and induces apoptosis in H1975 cells	PMC5821048
CL97 cells	4.1μM	48 hours	Dioscin inhibits cell viability and induces apoptosis in CL97 cells	PMC5821048
U2OS and 143B cells	2.5 μM	48 hours	Dioscin significantly increased the proportion of apoptotic cells	PMC5832770
RAW264.7 cells	300, 150, 75 ng/mL	6 hours	To evaluate the effect of Dioscin on the secretion of pro-inflammatory cytokines in RAW264.7 cells, results showed that Dioscin significantly inhibited the secretion of IL-1β, IL-6, TNF-α, and MCP-1.	PMC5695011
MH-S cells	200 nM, 400 nM, 800 nM		Dioscin treatment reduced CS-induced apoptosis in MH-S cells and promoted autophagy.	PMC6485284
Human Umbilical Vein Endothelial Cells (HUVECs)	1.25 mg/L and 5 mg/L		Dioscin promoted endothelial cell proliferation, migration, and tube formation under hypoxic conditions, indicating its pro-angiogenic effects.	PMC8282240

Rats and mice	DOX-induced myocardial injury model	Oral	Rats: 60, 30, 15 mg/kg; Mice: 80, 40, 20 mg/kg	Once daily for seven consecutive days	To investigate the protective effect of Dioscin against DOX-induced myocardial injury, the results showed that Dioscin significantly improved ECG changes, reduced serum CK and LDH levels, and improved myocardial histopathological changes	PMC5953242
C57BL/6 mice	silicosis model	Oral	20, 40, 80 mg/kg	once daily for 56 days	To evaluate the effect of Dioscin on pulmonary fibrosis in a silicosis mouse model, results showed that Dioscin significantly reduced collagen deposition and alleviated pulmonary fibrosis.	PMC5695011
Nude mice	Xenograft model	Intraperitoneal injection	10 mg/kg	Every two days, until the end of the experiment	Dioscin delayed in vivo tumor growth, promoted Skp2 ubiquitination, and inhibited Skp2 expression.	PMC7000337
C57BL/6J mice	Ligation-induced periodontitis model	Gingival injection	10 mg/kg	Once every other day for 2 weeks	Dioscin significantly reduced alveolar bone loss in ligation-induced periodontitis mice and suppressed the inflammatory response in periodontal tissues.	PMC10878154
BALB/c-Nude mice	NCI-H520 xenograft model	Oral	80 mg/kg/day	once daily for 12 days	Dioscin significantly inhibited the growth of NCI-H520 xenograft tumors, with a significant reduction in tumor volume and weight, and induced tumor cell apoptosis.	PMC7545707
C57BL/6 mice	Myocardial Infarction Model	Intragastric administration	40 µg/g	Once daily for 2 weeks	Dioscin significantly improved cardiac function in mice with myocardial infarction, reduced cardiac fibrosis and apoptosis, and alleviated cardiac damage by promoting angiogenesis.	PMC8282240
Nude mice	NOZ cell xenograft model	Injection	0, 5, 10 mg/kg	Every 3 days for 25 days	To evaluate the inhibitory effect of Dioscin on NOZ cell xenograft tumors	PMC5485633
Nude mice	Osteosarcoma xenograft model	Oral	60 mg/kg	Once daily until the end of the experiment	Dioscin significantly inhibited the growth of osteosarcoma xenografts without obvious side effects	PMC5832770
rats	diethylnitrosamine-induced primary liver cancer model	Oral	15, 30, 60 mg/kg	once daily for 18 weeks	Dioscin significantly inhibited diethylnitrosamine-induced primary liver cancer in rats, improved body weight changes, and restored serum levels of AFP, ALT, AST, γ-GT, ALP, and Ki67.	PMC6433650

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CAS No.: 19057-60-4

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CAS No.: 19057-60-4

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed